C57BL/6 마우스에서 로즈마리 오일의 육안적, 조직학적 모발성장 촉진효과
The Promoting Effect of Rosemary Oil on Hair Growth by Gross and Histological Observation in C57BL/6 Mice
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초록
This study was carried out to investigate the effect of rosemary essentialoil on hair growth in a shaving animal model of C57BL/6 mice. Five weeks old male mice were divided into four groups including normal group (N; saline), vehicle control group (VC; jojoba oil), positive control group (PC; 3% minoxidil) and experimental group (E; 3% rosemary oil) and they were topically applied with an amount of 100 μL once a day, 6 days a week, for 4 weeks. At 4-week application, hair regrowth on dorsal skin in E (42%) and PC (55%) groups was much faster than N (3%) and VC (20%) groups in gross observation. Hair follicle number, follicle depth and dermal thickness of E and PC groups were significantly higher (p<0.05) than N group in histological observation. And number of mast cells in dermis and hypodermis of E and PC groups were significantly lower (p<0.05) than N and VC groups. These results indicate that rosemary oil effectively stimulated hair growth in an animal model.
Abstract
This study was carried out to investigate the effect of rosemary essentialoil on hair growth in a shaving animal model of C57BL/6 mice. Five weeks old male mice were divided into four groups including normal group (N; saline), vehicle control group (VC; jojoba oil), positive control group (PC; 3% minoxidil) and experimental group (E; 3% rosemary oil) and they were topically applied with an amount of 100 μL once a day, 6 days a week, for 4 weeks. At 4-week application, hair regrowth on dorsal skin in E (42%) and PC (55%) groups was much faster than N (3%) and VC (20%) groups in gross observation. Hair follicle number, follicle depth and dermal thickness of E and PC groups were significantly higher (p<0.05) than N group in histological observation. And number of mast cells in dermis and hypodermis of E and PC groups were significantly lower (p<0.05) than N and VC groups. These results indicate that rosemary oil effectively stimulated hair growth in an animal model.
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