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Effects of Lavender Oil on Hair Growth-Relevant Enzyme Activity and Cytokine Expression in C57BL/6 Mice

김영철|이부형|심미자
대한미용학회 (The Korean Society for Investigative Cosmetology)|2016.03|대한미용학회지 (Journal of Investigative Cosmetology)|제12권 제1호|pp. 1-8|DOI 10.15810/jic.2016.12.1.001

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참고문헌

키워드

VEGFC57BL/6 miceIGF-1Lavender oilγ-GTC57BL/6 마우스라벤더오일

초록

This study conducted to determine the effects of lavender oil (LO) on hair growth-relevant enzyme activity and cytokine expression in C57BL/6 mice. At week 4, the activities of γ-GT in the PC, E1, and E2 groups were 25%, 11%, and 15% significantly (p<0.05) higher than the N group, respectively. The expression of growth factors including KGF, IGF-1, HGF, and VEGF increased as time passed. At week 4, compared to the N group, KGF mRNA expression significantly (p<0.05) increased by 15%, 10%, and 10% in the PC, E1, and E2 groups, respectively. Those of IGF-1 mRNA expression significantly (p<0.05) increased by 29%, 21%, and 21%, respectively. Those of HGF mRNA expression significantly (p<0.05) increased by 36%, 14%, and 18%, respectively. Those of VEGF mRNA expression significantly (p<0.05) increased 47%, 24%, and 24%, respectively. The correlation coefficient between hair growth area and KGF mRNA expression was 0.940. Putting the results together, we found that LO has hair growth-promoting effects as identified by hair growth-relevant enzyme activity and cytokine expression in C57BL/6 mice.

Abstract

The purpose of this study was to determine the effects of lavender oil (LO) on hair growth-relevant enzyme activity and cytokine expression in C57BL/6 mice. The experimental animals were divided into the following groups: i) normal (N: saline), ii) vehicle control (VC: jojoba oil), iii) positive control (PC: 3% minoxidil), iv) experimental 1 (E1: 3% LO), and v) experimental 2 (E2: 5% LO). Test compound solutions were topically applied to the backs of the mice (100 μL per application), once per day, 5 times a week, for 4 weeks. At week 4, the activities of γ-glutamyl transpeptidase (GT) in the E1 and E2 groups were 11% and 15% higher than the N group (p<0.05), respectively. The expression levels of keratinocyte growth factor (KGF) mRNA were significantly greater [10%; (p<0.05)] in the E1 and E2 groups, compared to the N group. The expression of insulin-like growth factor (IGF)-1 mRNA also significantly increased by 21% and 22% (p<0.05) in the E1 and E2 groups, compared to the N group, respectively. Hepatocyte growth factor (HGF) mRNA expression levels were significantly higher in the E1 and E2 groups than the N group [14% and 17%; (p<0.05)], respectively. The expression of vascular endothelial growth factor (VEGF) mRNA increased by 22% (p<0.05) in both the E1 and E2 groups, when compared to the N group. The correlation coefficients among hair growth-relevant factors were significantly high each other (p<0.001). The correlation coefficient between hair growth area and KGF mRNA expression was 0.940. These results confirm that LO has hair growth-promoting effects as identified by hair growth-relevant enzyme activity and cytokine expression in C57BL/6 mice.

참고문헌 (39)

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관련 논문AI추천

The Changes in Hair Growth-Relevant Enzyme Activity and Cytokine Expression Induced by Topical Application of Sandalwood Oil to C57BL/6 Mice김영철, 이복순, 홍성희대한미용학회 · 대한미용학회지2015 · 제11권 제1호Effects of Sandalwood Oil on Aspects of Hair Growth in a C57BL/6 Mouse Model of Alopecia이복순대한미용학회 · 대한미용학회지2014 · 제10권 제4호어성초를 포함한 천연복합추출물의 C57BL/6 마우스에 대한 발모효과배송환, 서형주, 홍양희한국피부과학연구원 · 아시안뷰티화장품학술지2015 · 제13권 제3호C57BL/6 마우스에서 로즈마리 오일의 육안적, 조직학적 모발성장 촉진효과김미향, 김영철대한미용학회 · 대한미용학회지2010 · 제6권 제2호Melandrium firmum Extract Promotes Hair Growth by Modulating 5α-Reductase Activity and Gene Expression in C57BL/6J Mice강범구, 임순성, Bo Huang, Xian Hua Zhang대한피부과학회 · Annals of Dermatology2019 · 제31권 제5호마우스에서 하수오 열수추출물이 발모관련 효소활성과 유전자 발현에 미치는 영향김영철, 이경미, 이재순대한미용학회 · 대한미용학회지2010 · 제6권 제3호

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