Evaluation of gargling Cololo solution for bacterial growth inhibition
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Purpose: The aims of this study were to analyze whether or not Cololo SP solution developed in Japan could be an alternative or superior to Hexamedine solution. Materials and Methods: Analysis was done by evaluating the bactericidal effects of mouthwash. Several methodologies tested, e.g., mixing bacteria directly into the mouthwash and long-term treatment of bacteria with solution. Results: Bacterial suspension treated twice with 80-fold diluted Cololo SP solution (1 hour of incubation at room temperature [RT] and 4 hours of incubation at RT) was more effective than single-directed inoculation of bacteria mixed with Cololo SP solution. Conclusion: The recommended dosage for Hexamedine solution application is two times for 1 min/d, and application should not be continued for more than 2 weeks. Thus, a new therapy needs to be developed to facilitate its continuous application as a mouthwash. Hexamedine solution is generally harmful if used for even 10 days. Therefore, our data suggest that Cololo SP solution would be a better alternative to Hexamedine solution.
Abstract
Purpose: The aims of this study were to analyze whether or not Cololo SP solution developed in Japan could be an alternative or superior to Hexamedine solution. Materials and Methods: Analysis was done by evaluating the bactericidal effects of mouthwash. Several methodologies tested, e.g., mixing bacteria directly into the mouthwash and long-term treatment of bacteria with solution. Results: Bacterial suspension treated twice with 80-fold diluted Cololo SP solution (1 hour of incubation at room temperature [RT] and 4 hours of incubation at RT) was more effective than single-directed inoculation of bacteria mixed with Cololo SP solution. Conclusion: The recommended dosage for Hexamedine solution application is two times for 1 min/d, and application should not be continued for more than 2 weeks. Thus, a new therapy needs to be developed to facilitate its continuous application as a mouthwash. Hexamedine solution is generally harmful if used for even 10 days. Therefore, our data suggest that Cololo SP solution would be a better alternative to Hexamedine solution.
참고문헌 (7)
- World Health Organization, "WHO model list of essential medicines", WHO, ~ (2013)
- Hagi A, "Bactericidal effects and mechanism of action of olanexidine gluconate, a new antiseptic", Antimicrob Agents Chemother, 59, pp.4551~4559 (2015)
- Leikin JB, "Poisoning and toxicology handbook", pp.183~184 (2008), Informa Healthcare USA, Inc.
- Sadat Sajadi F, "Effect of fluoride, chlorhexidine and fluoride-chlorhexidine mouthwashes on salivary streptococcus mutans count and the prevalence of oral side effects", J Dent Res Dent Clin Dent Prospects, 9, pp.49~52 (2015)
- Vale GC, "Recolonization of mutans Streptococci after application of chlorhexidine gel", Braz Dent J, 25, pp.485~488 (2014)
- Kolahi J, "Rinsing with chlorhexidine gluconate solution after brushing and flossing teeth: a systematic review of effectiveness", Quintessence Int, 37, pp.605~612 (2006)
- Hasegawa H, "Antimicrobial effects of carbamide peroxide against a polymicrobial biofilm model", Am J Dent, 28, pp.57~60 (2015)