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상황버섯과 발아현미상황버섯 열수추출물의 Murin Macrophage RAW 264.7 세포에서 항염증 반응 비교

Comparative Effect on Anti-Inflammatory Activity of the Phellinus linteus and Phellinus linteus Grown in Germinated Brown Rice Extracts in Murine Macrophage RAW 264.7 Cells

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Abstract

The present study describes the preliminary evaluation of the anti-inflammatory activities of Phellinus linteus (PL) and Phellinus linteus Grow in Germinated Brown Rice (BRPL). In order to effectively screen for anti-inflammatory agents, we first examined the extracts' inhibitory effects on the expression of pro-inflammatory cytokines activated with lipopolysaccharide. Moreover, we examined the inhibitory effects of the PL and BRPL extracts on pro-inflammatory factors such as NO, iNOS, TNF-α and IFN-γ in murine macrophage RAW 264.7 cells. NO production and iNOS expression was significantly augmented in LPS treated cell, the production of NO and iNOS was greater in the BRPL than in the PL group. In addition, protein and mRNA levels of TNF-α and IFN-γ in BRPL showed relatively more potent pro-inflammatory-activity inhibition compared to that of PL. These results suggest that BRPL may have significant effects on inflammatory factors, and may be a potential anti-inflammatory therapeutic materials.

참고문헌 (28)

  1. Chang ST, "In mushroom biology and mushroom products", pp.1~20 (1993), World Scientific
  2. Chihara G, "Fractionation and purifieation of the polysaccharide with marked antitumor activity, cspecially lentinan from Lentinus edodes", Cancer Research, 30, pp.2776~2781 (1970)
  3. Se Young Choi, "In-vitro Anti-inflammatory Activity of Rubus coreanusMiq. on Nitric Oxide, Interferon-γ, Cycloxygenase-2, andTumor Necrosis Factor-α Production in the Macrophagelike Cell Line RAW 264.7", 한국약용작물학회지, 15(5), pp.322~328 (2007), 한국약용작물학회
  4. Funk CD, "Human platelet", erythroleukemia cell prostaglandin G, The Faseb Journal, pp.1991, 5[DOI]
  5. Higuchi M, "Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages", The Journal of Immunology, 144, pp.1425~1431 (1990)
  6. Ji JH, "Antimutagenic and cytotoxicity effects of Phellinus linteus extracts", Journal of Korena Society of Food Science and Nutrition, 29, pp.322~328 (2000)
  7. Kim DH, "Effect of artificially cultured Phellinus linteus on harmful intestinal bacterial enzymes and rat intestinal α-glucocidase", The Korean Society of Food Hyglene and Safety, 13, pp.20~23 (1998)
  8. 박수영, "큰비쑥(Artemisia fukudo) 추출물의 murine macrophage RAW", 한국식품과학회지, 39(4), pp.464~469 (2007), 한국식품과학회
  9. Kim SY, "Antiinflammatory and Antioxidative Effects of Morus spp", Fruit Extract. The Korean Society of Medical Crop Science, 6, pp.204~209 (1998)
  10. 이연희, "발아현미상황버섯이 아토피피부염에 미치는 영향", 한국미용학회지, 13(2), pp.514~519 (2007), 한국미용학회
  11. Li G, "Protein-bound Polysaccharide from Phellinus linteus induces G2", M phase arrest and apoptosis in SW408 human colon cancer cells, 2004, pp.216, 175~181
  12. Lim BO, "Phellinus linteus grown on germinated brown rice suppresses IgE production by the modulation of Th1", Th2 balance in murine mesenteric lymph node lymphocytes, 2005, pp.27, 613~617
  13. 임병우, "DSS로 유도된 염증성 장 질환 마우스 동물모델에서 생식이 장관 임파조직내 면역조절 기능에 미치는 영향", 한국식품영양과학회지, 36(1), pp.32~42 (2007), 한국식품영양과학회
  14. 임병우, "한약재인 황금의 궤양성 실험동물에 대한 장간막 임파절 임파구의 면역글로블린 수준, T세포 집단, 사이토카인 생성의 조절작용", 한국약용작물학회지, 16(2), pp.100~105 (2008), 한국약용작물학회
  15. McCartney N, "Suppression of arthritis by an inhibitor of nitic oxide synthase", The Journal of Experimental Medicine, 178, pp.749~754 (1993)
  16. MeDaniel ML, "Cytokines and nitric oxide in islet inflammation and diabetes", Proceedings of the Society for Experimental Biology and Medicine, 211, pp.24~32 (1996)
  17. Moncada S, "Nitric oxide: physiology, pathophysiology, and pharmacology", Pharmacological reviews, 43, pp.109~142 (1991)
  18. Mu MM, "The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in raw 264.7 macrophage cells", Journal of Endotoxin Research, 7, pp.431~438 (2001)
  19. Park SJ, "Inhibition of LPS induced iNOS, COX-2 and cytokines expression by Genistein-4'-O-α-L-Rhamnopyranosyl-(1-2)-β-D-Glucopyranoside through the NF-κB inactivation in raw 264.7 cells", Korean Society of Pharmacology, 38, pp.339~348 (2007)
  20. Piguet PF, "Tumor necrosis factor is a critical mediators in hapten induced irritant and contact hypersensitivity reaction", The Journal of Experimental Medicine, 173, pp.673~679 (1991)
  21. Pociot F, "Association of tumor necrosis factor (TNF) and class major histocompatibility complex alleles with the secretion of TNF-α and TNF-β by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus", European Journal of Immunology, 23, pp.224~231 (1993)
  22. Ryu JH, "Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophage", Phytotherapy Research, 17, pp.485~489 (2003)
  23. Stuehr HH, "Purification of the cytokine-induced macrophage nitric oxide synthase: and FAD- and FMN- containing flavoprotein", Proceedings of the National Academy of Sciences of the United States of America, 88, pp.7773~7777 (1991)
  24. Tizard IR, "Veterinary Immunology : An Introduction" (2004), W. B. Saunders Company
  25. Weisz A, "Regulation of the mouse inducible-type nitric oxide synthase gene promoter by interferon-gamma, bacterical lipopolysaccharide and NG-monomethy1-L-arginene", Biochemical Journal, 316, pp.209~215 (1996)
  26. Willoughby DA, "Human arthritis applied to animal models. Towards a better therapy", Annals of the Rheumatic Diseases, 34, pp.471~478 (1975)
  27. Willeaume V, "Tumor necrosis factor-alpha production induced by viruses and by lipopolysaccharides in macrophages: similarities and differences", Journal of Inflammation, 46, pp.1~12 (1996)
  28. Jeong-Lye Yang, "β-Glucan Suppresses LPS-stimulated NO Production Through the Down-regulation of iNOS Expression and NFκB Transactivation inRAW 264.7 Macrophages", Food Science and Biotechnology, 17(1), pp.106~113 (2008), 한국식품과학회

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