상황버섯 균사체를 이용한 발효주의 추출물이 염증관련 단백질의 발현과 세포내 활성산소 생성에 미치는 영향
Effect of the Evaporating Extract from Liquor of Fermentation Using Mycelium of Phellinus linteus on the Expression of Inflammatory Proteins and the Generation of Reactive Oxygen Species
2
조회
0
다운로드
3
인용
0
참고문헌
초록
Abstract
Phellinus linteus is known as a medicinal mushroom, which has the pharmaceutical activity on tumors and inflammatory diseases in traditional Oriental medicine. However, despite extensive pharmacological studies on P. linteus, the liquor of fermentation using mycelium of P. linteus(LFMP) has not been investigated. In the present study, it was examined the effect of the evaporating extract from LFMP(E-LFMP) on the expression of inflammatory proteins and the generation of reactive oxygen species in human hepatocarcinoma HepG2 cells. E-LFMP inhibited acetaldehyde-induced morphological change in HepG2 cells. Also, E-LFMP inhibits expression of inflammatory proteins including cyclooxygenase(COX)-1 and COX-2 through suppressing nuclear translocation of nuclear factor κB(NF-κB) and degradation of inhibitory κBα(IκBα). In addition, E-LFMP inhibits generation of reactive oxygen species(ROS) by hydrogen peroxide(H2O2) in HepG2 cells. These results suggest that LFMP has the pharmaceutical, especially anti-inflammatory, activity similar to P. linteus mushroom.
참고문헌 (23)
- "Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-", pp.1656~1662 (2004)
- "Induction of apoptotic cell death by mycelium extracts of Phellinus linteus in", pp.227~232 (2004)
- "Mycelial culture of Phellinus linteus protects primary cultures rat hepatocytes", j eth(pharmacol 95), pp.367~372 (2004)
- "버섯균사체가 분비하는 알코올의 생산과 이를 이용한 기능성 주류의 개발" (2004)
- "Ethanol metabolism and transcription factor activation in", pp.106~118 (2002)
- "Acetaldehyde induces granulocyte macrophage colony- stimulating factor production in human bronchi through activation of nuclear factor-kappa B", koh, pp.367~371 (2003)
- "Oxidative stress and antioxidant defenses in" (2004)
- "Nitric oxide and interleukin-8 as inflammatory", pp.587~598 (1995)
- "Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha Role of NF-kappa B and AP-1", pp.50887~50896 (2003)
- "Cyclooxygenases in cancer", pp.1~20 (2004)
- "potential molecular targets for chemoprevention", pp.1089~1100 (2004), Signal transduction pathways regulating cyclooxygenase-2 expression
- "Control of COX-2 and iNOS gene expressions by", pp.273~276 (2003)
- "Antioxidants and prevention of chronic disease", pp.275~295 (2004)
- "REACTIVE OXYGEN SPECIES: Metabolism, Oxidative Stress", pp.373~399 (2004)
- "oxidative stress, and cytokine-induced liver cell injury", etha(l), pp.63~68 (2002)
- "Alcohol inhibits cell-cell adhesion", pp.381~390 (1996)
- "Integrating an integrin a direct route to actin", pp.47~54 (2004)
- "Role of protein tyrosine phospho- rylation in acetaldehyde-induced disruption of epithelial tight junctions" (2001)
- "L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer" (2004)
- "버섯의 면역활성", pp.86~90 (1998)
- "Ethanol- induced iNOS and COX-2 expression in cultured astrocytes via NF-kappa B", pp.681~685 (2004)
- "a novel treatment for lung cancer", pp.725~734 (2004)
- "Players in the Platelet Game" (1988)