본문 바로가기
KERD
논문

마우스 Raw 264.7 세포에 대한 4종 대황류 추출물의 항염증 활성 비교

Comparative Study of Extracts from Rhubarb on Inflammatory Activity in Raw 264.7 Cells

이아영|김호경|김승주|최고야|문병철|추병길|윤태숙|전명숙
한국약용작물학회|2009.04|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제17권 제2호|pp. 109-114

2

조회

0

다운로드

21

인용

0

참고문헌

초록

Abstract

Rhubarb is the well-known and frequently used herbal medicine for the treatment of constipation, inflammation, and cancer. As described in the Korea and Chinese Pharmacopoeia, rhubarb consists of the roots and rhizomes of Rheum palmatum, R. officinale, and R. tanguticum. However, the pharmacological differences among rhubarb have not been scientifically established. In the present study, we investigated and compared the inhibitory effects of 70% ethanolic extracts from R. palmatum (RPE), R. officinale (ROE), R. nobile (RNE), and R. franzenbachii (RFE) on the production of inflammatory mediators, nitric oxide (NO), prostaglandin E2 (PGE2), interlukin-1beta (IL-1β), and tumor necrosis factor-alpha (TNF- α) in RAW 264.7 macrophage cells. ROE, RNE, and RFE significantly inhibited the release of NO, PGE2, IL-1β, and TNF-α. RPE significantly reduced the release of IL-1β, but not NO, PGE2, and TNF-α. Overall, RFE was found to inhibit the release of PGE2 and IL-1β, to a far greater degree than RPE, ROE, and RNE. Our results indicate that RFE possess the strongest anti-inflammatory activity among 4 tested rhubarb.

참고문헌 (28)

  1. Baumann H, "The acute phase response", Immunology Today, 15, pp.74~80 (1994)
  2. Darias V, "Analgesic activity of some phenolic components in rhubarb", II Farmaco, 33, pp.460~465 (1987)
  3. Duke JA, "Handbook of medicinal herbs", pp.621~ (2002), CRC Press
  4. Fujiwara N, "Macrophages in inflammation. Current Drug Targets", Inflammation and Allergy, 4, pp.281~286 (2005)
  5. Gracie JA, "A proin-flammatory role for IL-18 in rheumatoid arthritis", Journal of Clinical Investigation, 104, pp.1393~1401 (1999)
  6. Guha M, "LPS induction of gene expression in human monocytes", Cell Signalling, 13, pp.85~94 (2001)
  7. Jang M, "Cancer chemopreventive activity of resveratrol, a natural product derived from grapes", Science, 275, pp.218~220 (1997)
  8. 김형환, "Vasodilation Effect of the Water Extract of Rheum palmatum L. in Rat Thoracic Aorta.", 대한본초학회지, 17(2), pp.12~117 (2002), 대한본초학회
  9. Kinne RW, "Macrophages in rheumatoid arthritis", Arthritis Research, 2, pp.189~202 (2000)
  10. 고성권, "종대황 스틸벨 유도체의 Cyclooxygenase 저해작용", 생약학회지, 34(1), pp.25~27 (2003), 한국생약학회
  11. 고성권, "Carrageenan 유발 족부종에 미치는 종대황 스틸벤 유도체의 효과", 생약학회지, 35(2), pp.171~174 (2004), 한국생약학회
  12. Kundu JK, "Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals", Mutation Research, 591, pp.123~146 (2005)
  13. Lee SH, "Induction of apoptosis by 3,4'-dimethoxy-5-hydroxystilbene in human promyeloid leukemic HL-60 cells", Planta Medica, 68, pp.123~127 (2002)
  14. 이용규, "대식세포주 RAW264.7 세포에서 Curcumin의 Lipopolysaccharide 에 의한 Nitric Oxide 생성 억제 효과", 한국약용작물학회지, 15(6), pp.451~456 (2007), 한국약용작물학회
  15. Li HL, "Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophages", International Journal of Molecular Medicine, 16, pp.41~47 (2005)
  16. Mariathasan S, "Inflammasome adaptors and sensors: intracellular regulators of infection and inflam-mation", Nature Reviews. Immunology, 7, pp.31~40 (2007)
  17. Matsuda H, "Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides", Bioorganic and Medicinal Chemistry, 9, pp.41~50 (2001)
  18. McCann SM, "The nitric oxide theory of aging revisited", Annals of the New York Academy of Sciences, 1057, pp.64~84 (2005)
  19. Miyamoto M, "Studies on the purgative substance I, isolation of sennoside A, one of the most active principles from rhubarbs", Yakugaku Zasshi, 87, pp.1040~1043 (1967)
  20. Nathan C, "Nitric oxide as a secretory product of mammalian cells", The FASEB Journal, 6, pp.3051~3064 (1992)
  21. Paik SB, "Screening of medicinal plants with antifungal activity on major seedborne disease", Korean Journal of Medicinal Crop Science, 6, pp.277~285 (1998)
  22. Paul A, "Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages", Cell Signalling, 11, pp.491~497 (1999)
  23. Roth RA, "Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?", Toxicology and Applied Pharmacology, 147, pp.300~311 (1997)
  24. 센팅, "반지련 (Scutellaria barbata D. Don) 추출물이 lipopolysaccharide에 의해 활성화된 대식세포에 미치는 영향", 한국약용작물학회지, 16(5), pp.313~319 (2008), 한국약용작물학회
  25. Xiao P, "Ethnopharmacologic study of Chinese rhubarb", Journal of Ethnopharmacology, 10, pp.275~293 (1984)
  26. Ye M, "Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry", Journal of the American Society for Mass Spectrometry, 18, pp.82~91 (2007)
  27. 윤준용, "강화사자발쑥의 마크로파지 RAW 264.7세포에 대한 Tumor Necrosis Factor-α, Prostaglandin E2, Cyclooxygenase-2 및 LPS 유도 Nitric Oxide 생성 저해", 한국약용작물학회지, 16(5), pp.326~331 (2008), 한국약용작물학회
  28. Zedler S, "The impact of endogenous triggers on trauma-associated inflammation", Current Opinion in Critical Care, 12, pp.595~601 (2006)

관련 논문AI추천

LPS로 자극된 Raw 264.7 대식세포에서 한약재복합 추출물의 세포독성 및 항염증 효과김세기, 박근혜, 박찬익한국화장품미용학회 · 한국화장품미용학회지2016 · 제6권 제1호RAW264.7세포주와 염증생쥐모델에서 抗炎症 作用에 대한 行經紅花湯의 效果민병호, 유동열대한한방부인과학회 · 대한한방부인과학회지2005 · 제18권 제4호解毒四物湯의 抗炎效果 및 免疫反應에 關한 硏究김양호, 조한백대한한방부인과학회 · 대한한방부인과학회지2008 · 제21권 제2호RAW264.7세포주와 염증생쥐모델에서 抗炎症 作用에 대한 淸熱活血湯加鷄血藤의 效果유동열, 한충희대한한방부인과학회 · 대한한방부인과학회지2005 · 제18권 제3호LPS로 유도된 RAW 264.7 세포에서 연자심(Plumula Nelumbinis) 추출물의 항염증 활성 검증유단희, 이인철대한미용학회 · 대한미용학회지2025 · 제21권 제2호當歸芍藥散이 마우스 대식세포주의 NO 생성 및 사이토카인 유전자 발현에 미치는 영향권영규, 권택규, 박종현, 서성일, 신상우, 이영선한의병리학회 · 동의생리병리학회지2004 · 제18권 제5호

이 간행물의 다른 논문 (10건)

복분자 추출물의 나노입자화를 통한 항산화 및 미백 효과 증진하지혜, 김승섭, 김영, 정명훈, 이현용, 오성호, 정향숙, 최근표, 한재건, 박욱연pp. 81-89생쥐에서 디젤배기가스 입자에 의한 기도염증과 기도 과민성에 미치는 홍삼 조사포닌의 영향임흥빈, 김승형pp. 90-96상황버섯과 발아현미상황버섯 열수추출물의 Murin Macrophage RAW 264.7 세포에서 항염증 반응 비교임병우, 최세영, 박동기, 전윤희, 안치선, 정용준pp. 97-101초고압 추출 처리에 의한 마황과 당귀의 항암 활성 증진김승섭, 한재건, 박욱연, 정향숙, 최근표, 하지혜, 김영, 정명훈, 이현용, 오성호pp. 102-108이용부위 및 채취시기에 따른 꾸지뽕나무 메탄올 추출물의 항산화성김종엽, 유동현, 류정, 박춘봉, 김대향, 최소라pp. 115-120
원문 보기