일시 · 장기간 운동이 정신지체여성의 항산화능력에 미치는 영향
Effects of Acute · Chronic Exercise on Antioxidant Enzyme in Mental Retarded Female
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정신지체인은 타인의 의존심이 강하고 중증일수록 운동과 감각능력의 저하와 식이에 대한 욕구가 강해 정상인에 비해 비만도가 높다. 이런 비만으로 인해 여러 가지 질병을 초래할 수 있다. 또한 활성산소의 일종인 과산화 수소음이온 라디칼이 정신지체의 원인이 될 수 있으며 동맥경화나 알츠하이머(Alzheimer's)증상으로 악화될 수 있다는 선행연구와 실제 정신지체의 가장 흔한 유전적 요인인 다운증후군(Down' syndrome)의 경우 세포내의 산소종(oxygen species)이나 지질과산화 수준이 3～4배 높다고 하며, 이것은 신경의 괴사를 초래할 수 있다고 한다. 그래서 본 연구는 특히 정신지체여성들은 통제된 환경과 정신지체에서 오는 자아의식 상실, 앉아 있는 생활습관과 신체활동의 제한으로 인한 비만 이러한 모든 것이 정신지체여성으로 하여금 급격한 대사관련 호르몬의 변화와 활성산소 발생 증가가 있을 것이라 생각하며, 이러한 것이 신체활동 능력을 더욱더 저하할 수 있다고 보고 정상인과의 비교와 운동시 생성되는 항산화 효소의 변화가 어떻게 이루어지는지에 대한 연구로 정상인과 마찬가지 장기간 운동의 효과를 입증하였다.
Abstract
The purpose of this study was to investigate the effect of acute and chronic exercise about MDA and antioxidant enzyme(SOD, CAT). Ten retarded women (age 27.6±5.48, weight 53.6±12.53) who had not performed regular exercise in previous 2 yr were studied. All subjects were free from known disease. Training which is consisted of running and aerobic exercise. All parameters were measured and analysed before and after training. Maximal oxygen consumption was determined during altered incremental treadmill test. Blood sample was obtained at rest before the test, immediately on completion of the test, and at recovery of 30 min. All participants were tested before and after 12-wk exercise periods. Cortisol concentration did not show any change during acute and chronic exercise. In acute exercise, there was no change in MDA both acute and chronic exercise. Significant differences were observed in SOD between normal control and mental retardation group before training. In chronic effects average plasma SOD concentration increased significantly at immediately exercise. in contrast to pre exercise and recovery in all group and the rate of increases in SOD was higher after training than before training. This increase returned to baseline level during recovery. In conclusion, chronic exercise of mentally retarded adult women showed enhanced exercise capacity. Acute exercise resulted in enhanced metabolic capacity. Acute exercise did not show any change in lipid peroxidation despite of increased Vo2max. The reason of this result may be due to increase antioxydant enzyme(SOD). Further investigation is needed to elucidate the exact mechanism related to the difference of sex, excercise intensity, and molecular approach.
참고문헌 (20)
- "정신지체아의 지체 정도를 중심으로 한 비만에 관한 문헌고찰", 2, pp.64~87 (2000)
- "교육가능한 정신지체아 (EMR)의 심폐기능에 대한 연구", pp.100~116 (1993)
- "정신지체아 지도의 이론과 실제" (1993), 도서출판 성원사
- "Cu", Zn superoxide dismutase mRNA enzyme activity, and susceptibility to lipid peroxidation, increase with aging in murine brain, 1992, pp.13(3), 87~179
- "Apoptosis and increased generation of reactive oxygen species in Down's syndrome neuron in vitro", 378(6559), pp.21~28 (1995)
- "Physical Fitness and Exercise Training of Individual Mental Retardation.", pp.442~540 (1993)
- "Prevalence of obesity among Mentally retanded adult", 87, pp.228~230 (1982)
- "The relationship of oxygen uptake to superoxide dismutase and catalase activity in human skeletal muscle. International", 5, pp.11~14 (1984)
- "Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and post exercise", 74, pp.965~969 (1993)
- "Obesity levels in institutionalized mentally retarded adults", 3, pp.167~176 (1986)
- "muscle oxidative capacity, antioxidant enzymes and exercise training", 68(6), pp.2337~2339 (1990)
- "Are indices of free radical damage relate to exercise intensity", 56, pp.313~316 (1987)
- "Delayed on set muscle damage and lipid peroxidation in man after a downhill run", 12, pp.332~336 (1989)
- "Strenuous endurance training in human reduce oxidative stress following exhausting exercise", 84(1-2), pp.1~6 (2001)
- "Isoperenoid pathway and free radical generation and damage in neuropsychiatric disorders", 38(5), pp.438~446 (2000)
- "Developmental disabilities :Delivery of medical care for children and adults, Philadelphia : Lea & Febger." (1989)
- "Exercise induced oxidative stress : glutathione supplementation and deficiency", 77(5), pp.2177~2187 (1994)
- "Mental retardation: genetic findings, clinical implications and research agenda", 37(3), pp.259~280 (1996)
- "Antioxidative metabolism in down syndrome. Biol", 63(2), pp.123~127 (1998)
- "Lipid peroxides, prosacyclin, and thromboxane A2 in runners during acute exercise", 16, pp.275~277 (1984)