9주간 훈련이 정신지체여성의 MDA와 항산화 효소에 미치는 영향
Effect of 9weeks Exercise Training on MDA, Antioxidant Enzyme in Mentally Retarded Female
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이 연구는 정신지체인을 대상으로 운동부하 테스트와(안정시, 최대 운동부하 테스트 직후, 회복30분) 장기간 훈련(훈련전․후)이 지질과잉산화와 항산화 효소에 미치는 영향을 연구하기 위한 것이다. 여성 20명을 대상으로 훈련군 10명, 대조군 10명으로 나누어 9주간 운동 훈련을 실시하였다. 훈련군은 준비운동과 정리운동을 포함한 총 40-50분 동안 자전거 에르고메터와 트레이드밀을 이용하여 유산소 운동을 주 5회 실시하였으며, 대조집단은 일상생활을 유지하도록 하였다. 처치에 대한 효과를 살펴보기 위하여 처치전․후로 최대산소섭취량과 지질과잉산화의 척도인 MDA, 항산화 효소인 SOD, CAT를 검사하였으며, 자료처리는 반복측정에 의한 3원 변량분석을 적용하였다. 분석결과 최대산소섭취량은 훈련전에 비하여 훈련후 유의하게 증가하였다(p<.05). MDA와 항산화 효소는 운동부하 테스트직후 유의하게 증가하여 회복기에 감소하였다(p<.01). 9주간 훈련에 따른 변화에서 MDA는 변화를 보이지 않았지만 항산화효소인 SOD의 경우 운동부하 테스트 직후의 증가율이 훈련전에 비하여 훈련후 유의하게 높았다(p<.05). 결론적으로 탈진운동은 지질과잉산화를 증가시켰으며, 9주간의 운동 훈련은 항산화 효소를 중가 시키는 것으로 나타났다.
Abstract
The purpose of this study was to investigated the effects of acute and chronic exercise (9weeks) on VO2max, MDA and antioxidant enzyme (SOD, CAT). Twenty mentally retarded women were participated in this study and were divided control (n = 10, age 27.9 ± 4.89, weight 52.2 ± 7.19) and exercise training group (n = 10, age 28.7 ± 5.37, weight 51.7 ± 5.82). Each subjects performed maximal exercise test under controlled laboratory conditions. Blood sample was obtained before, immediately after and 30minutes later after an maximal exercise test to exhaustion. VO2max significantly increased in exercise training group after chronic exercise. The concentration of MDA significantly increased after immediately exercise and returned at base line level 30minutes later after completion of maximal exercise test in both group, but chronic exercise did not induce any significant change. SOD concentration increased significantly at immediately exercise in contrast to pre exercise and the rate of increases was more higher in exercise training group than control group. This increase returned to base line level during recovery. CAT concentration did not change with acute and chronic exercise. In conclusion, acute exercise of mental retarded adult women showed increased lipid peroxidation and chronic exercise prevented this exercise induced increase by enhanced antioxidant enzyme capacity. Further investigation needed to elucidate the exact mechanism related to various exercise intensity, and comparing mental retarded person with normal one.
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