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聰明湯과 山査聰明湯이 Alzheimer's Disease 病態 모델에 미치는 影響

The Effects of ChongMyungTang(CMT) and SanSaChongMyungTang(SCMT) on the Alzheimer's Disease Model

정인철|이상룡|하수영
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2006.03|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제17권 제1호|pp. 59-78

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Abstract

Objective : This research investigates the effect of the CMT and SCMT on Alzheimer's disease. Methods : The effects of the CMT and SCMT on (1) amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT-105; (2) the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of IL-1β, TNF-α, MDA; (5) the infarction area of the hippocampus in Alzheimer's disease mice induced with CT105 & βA were investigated. Rresults : 1. The CMT and SCMT suppressed the expression of APP, AChE mRNA in PC-12 cells treated with CT-105. 2. The CMT and SCMT suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 3. For the CMT and SCMT group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The CMT and SCMT suppressed the over-expression of IL-1β, TNF-α, MDA in the mice with Alzheimer's disease induced by βA. 5. The CMT and SCMT reduced the infarction area of hippocampus with Alzheimer's disease induced by βA. Conclusions : These results suggest that the CMT and SCMT may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the CMT and SCMT for Alzheimer's disease is suggested for future research.

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