운동강도 차이가 비만 중년여성의 염증반응 지표와 인슐린저항성에 미치는 영향
Effects of Exercise Intensity on Inflammatory Response Index and Insulin Resistance in Obese Middle-aged Women
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초록
[PURPOSE] This study was carried out in order to find out the effects of exercise intensity in walking exercise program for 12 weeks on inflammatory response index and insulin resistance in obese middle-aged women. [METHODS] The subjects consisted of the moderate-intensity exercise group(n=10), high-intensity exercise group(n=10), and control exercise group(n=10). Each group had exercised 5 times a week for 12 weeks with the treadmill. The moderate-intensity exercise group had exercised for 50 minutes at 40～60% of heart rate reserve and the high-intensity group had exercised for 40 minutes at 60～80% of heart rate reserve. The changes of obesity index, inflammatory response index and insulin resistance in each group were measured and analyzed at pre- and post- walking exercise program for verifying exercise effectiveness. [RESULTS] The obesity index(weight, % fat and waist circumference), inflammatory response index(TNF--α, IL-6 and hs-CRP) and insulin resistance(blood glucose, insulin and HOMA-IR) of obese middle-aged women after walking exercise program were significantly decreased compared to pre-program, but there was no exercise intensity effects. [CONCLUSIONS] Moderate and high intensity exercise had the positive effects on reduced inflammatory reaction and insulin resistance induced by obesity, but they were not exercise intensity-dependent.
Abstract
[PURPOSE] This study was carried out in order to find out the effects of exercise intensity in walking exercise program for 12 weeks on inflammatory response index and insulin resistance in obese middle-aged women. [METHODS] The subjects consisted of the moderate-intensity exercise group(n=10), high-intensity exercise group(n=10), and control exercise group(n=10). Each group had exercised 5 times a week for 12 weeks with the treadmill. The moderate-intensity exercise group had exercised for 50 minutes at 40～60% of heart rate reserve and the high-intensity group had exercised for 40 minutes at 60～80% of heart rate reserve. The changes of obesity index, inflammatory response index and insulin resistance in each group were measured and analyzed at pre- and post- walking exercise program for verifying exercise effectiveness. [RESULTS] The obesity index(weight, % fat and waist circumference), inflammatory response index(TNF--α, IL-6 and hs-CRP) and insulin resistance(blood glucose, insulin and HOMA-IR) of obese middle-aged women after walking exercise program were significantly decreased compared to pre-program, but there was no exercise intensity effects. [CONCLUSIONS] Moderate and high intensity exercise had the positive effects on reduced inflammatory reaction and insulin resistance induced by obesity, but they were not exercise intensity-dependent.
참고문헌 (47)
- American College of Sports Medicine, "American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise", Medicine & Science in Sports & Exercise, 43(7), pp.1334~1359 (2011)
- American Diabetes Association, "Standards of medical care in diabetes-2012", Diabetes Care, 35, pp.11~63 (2012)
- Bajpeyi, S., "Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation", Journal of Applied Physiology, 106(4), pp.1079~1085 (2009)
- Baynard T., "Effect of single vs multiple bouts of exercise on glucose control in women with type 2 diabetes", Metabolism, 54, pp.989~994 (2005)
- Berg, A. H., "Adipose tissue, inflammation & cardiovascular disease", Circulation Research, 96(9), pp.939~949 (2005)
- Boule, N. G., "Meta-analysis of the effects of structured exercise training on cardio-respiratory in type 2 diabetes mellitus", Diabetologia, 46, pp.1071~1081 (2003)
- Byrne, C. D., "The metabolic syndrome" (2011), Wiley-Blackwell
- Cantrell, D. A., "Phosphoinositide 3-kinase signaling pathways", Journal of Cell Science, 114(8), pp.1439~1445 (2001)
- Cook, D. G., "C-reactive protein concentration in children:relationship to adiposity and other cardiovascular risk factors", Atherosclerosis, 149, pp.139~150 (2000)
- Dekker, M. J., "An exercise intervention without weight loss decreases circulation interleukin-6 in lean and obese men with and without type 2 diabetes mellitus", Metabolism, 56, pp.332~338 (2007)
- Dengel, D. R., "Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men", Journal of physiology, 81, pp.318~325 (1996)
- Fischer, C. P., "Interleukin-6 in acute exercise and training, what is the biological relevance?", Exercise Immunology Review, 12, pp.6~33 (2006)
- Ford, E. S., "Dose exercise reduce inflammation?:physical activity and C-reactive protein among U.S. adults", Epidemiology, 13, pp.561~568 (2002)
- Gari, M. A., "Moderate versus high intensity aerobic exercise training on glycemic control and anti-inflammatory effects on non-insulin dependent diabetes patients", World Applied Science Journal, 8(6), pp.667~671 (2010)
- Geffken, D. F., "Association between physical activity and markers of inflammation in a healthy elderly population", American Journal Epidemiology, 135, pp.242~250 (2001)
- Hawkins, M., "Joslin's Diabetes Mellitus" (2005), Lippicott Willians & Wilkins
- Hill, J. O., "Overview of the determinants of overweight and obesity:current evidence and research issues", Medicine & Science in Sports & Exercise, 31(11), pp.515~521 (1999)
- Horwitz, J. F., "Exercise-induced alterations in muscle lipid metabolism improve insulin sensitivity", Exercise Sport Science Review, 35, pp.192~196 (2007)
- Hotamisligil, G. S., "Adipose expression of tumor necrosis factor-a: Direct role in obesity-linked insulin resistance", Science, 259, pp.87~91 (1999)
- Hounmard, J. A., "Effects of volume and intensity of exercise training on insulin sensitivity", Journal of Applied Physiology, 96, pp.101~106 (2004)
- Jankord, R., "Influence of physical activity on serum IL-6 and IL-10levels in healthy older men", Medicine &Science in Sports & Exercise, 36(6), pp.960~964 (2004)
- 강현식, "운동 트레이닝 강도가 복부 비만 여성의 대사성 위험인자에 미치는 영향", Journal of Exercise Nutrition & Biochemistry, 14(4), pp.219~225 (2010), 한국운동영양학회
- Karvonen, M. J., "The effect of training of heart rate: A longitudinal study", Annales Medicine Experimental at Biologia Fennicae, 35, pp.307~315 (1957)
- Kelly, D. E., "Effects of physical activity on insulin action and glucose tolerance in obesity", Medicine & Science in Sports & Exercise, 31, pp.619~623 (1999)
- 고성경, "비만과 신체훈련이 염증유발인자들에 미치는 영향", 대한스포츠의학회지, 25(1), pp.18~25 (2007), 대한스포츠의학회
- Libardi, C. A., "Effects of concurrent training on interleukin-6, tumour necrosis factor-alpha and C-reactive protein in middle-aged men", Journal of Sports Science, 29(14), pp.1573~1581 (2011)
- Libby, P., "Inflammation in atherosclerosis", Circulation, 105, pp.1135~1143 (2002)
- Libby, P., "Inflammation and atherosclerosis: role of C-reactive protein in risk assessment", American Journal of Medicine, 116(6), pp.9~16 (2004)
- Matsuzawa, Y., "Importance of adipocytokines in obesity-related diseases", HormoneResearch, 60(3), pp.56~59 (2003)
- Matthews, D. R., "Homeostasis model assesment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)
- O'Donovan, G., "The effects 24 weeks of moderate- or high- intensity exercise on insulin resistance", European Journal Applied Physiology, 118, pp.346~354 (2005)
- 박수현, "12주 걷기 운동 프로그램의 운동강도가 비만여성의 신체조성, 복부지방, 심폐체력에 미치는 영향", 운동과학, 16(1), pp.1~10 (2007), 한국운동생리학회
- Pedersen, A. M., "The anti-inflammatory effect of exercise", Journal of Applied Physiology, 98, pp.1154~1162 (2005)
- Pedersen, B. K., "Muscle-derived interleukin-6, possible biological effects", Journal of Physiology, 536(2), pp.329~337 (2001)
- Ridker, P. M., "C-reactive protein and coronary heart disease", New England Journal Medicine, 351(3), pp.295~298 (2004)
- Ridker, P. M., "Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia", Circulation, 103(9), pp.1191~1193 (2002)
- Reaven, G. M., "Role of insulin resistance in human disease", Diabetes, 37, pp.1595~1607 (1988)
- Ross, R., "Physical activity, total and reginal obesity: dose-response considerations", Medicine &Science in Sports & Exercise, 33(6), pp.521~527 (2001)
- Ruan, H., "Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha", Cytokine Growth Factor Review, 14, pp.447~455 (2003)
- Sanz, C., "Physical exercise for the prevention and treatment of type 2 diabetes", Diabetes Metabolism, 36, pp.346~351 (2010)
- Shehab, M. A., "Exercise training modulated insulin resistance and inflammatory cytokines in obese non-insulin dependent diabetic patients", Advances in Environmental Biology, 6(2), pp.598~604 (2012)
- Signal, R. J., "Physical activity", exercise and type 2diabetes, 2004, pp.27(10), 2518~2535
- Slentz, C. A., "Inactivity, exercise, and visceral fat. STRRIDE: a randomized controlled study of exercise intensity and amount", Journal of Applied Physiology, 99(4), pp.1614~1688 (2005)
- Stewart, K., "Role of exercise training on cardiovascular disease in person who have type 2 diabetes and hypertension", Cardiology Clinics, 22, pp.569~586 (2004)
- Weisberg, S. P., "Obesity is associated with macrophage accumulation in adipose tissue", Journal of Clinic Investigation, 112, pp.1176~1808 (2003)
- Wilson, A. M., "The novel role of C-reactive protein in cardiovascular disease: Risk marker or pathogen", International Journal of Cardiology, 106, pp.291~297 (2006)
- Yokoyama, H., "Short-term aerobic exercise improves arterial stiffness in type 2 diabetes", Diabetes Research Clinical Practice, 65, pp.85~93 (2004)