일회성 유산소운동이 비만 중년여성의 염증반응인자와 혈중 아디포넥틴에 미치는 영향
Effects of Acute Aerobic Exercise on Circulating Adiponectin and Inflammatory Makers in Obese Middle-Aged Women
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연구배경: 운동강도는 염증반응인자와 아디포사이토카인의 변화를 자극하는 것으로 알려져 있다. 그러나 비만인에 있어 일회성 운동에 의한 아디포넥틴의 변화가 염증반응인자와 다른 아디포사이토카인들의 변화와 관련성이 있는지는 잘 알려져 있지 않다. 본 연구는 중년 비만 여성을대상으로 아디포사이토카인과 염증반응인자들의 변화에대한 일회성 유산소 운동의 효과를 알아보고자 하였다. 방법: 교차연구 설계를 이용하여, 10명의 비만 중년 여성을 대상으로 400 kcal의 에너지 소비량을 동일하게 맞추기 위해 최대산소섭취량 60%와 80%에 해당하는 각각의다른 속도와 시간을 적용한 트레드밀 일회성 운동을 실시하였다. 혈액은 글루코스, 인슐린, 피브리노겐, high sensitive C-reactive protein (hsCRP), 렙틴, tumor necrosis factor α (TNF-α) 그리고 아디포넥틴 농도를 측정하기 위해채혈하였다. 결과: 글루코스, 피브리노겐, hsCRP는 유의한 증가(P<0.05)를 보인 반면, 인슐린저항성은 유의한 감소(P<0.05)를 나타내었다. 그러나 아디포넥틴, 렙틴, TNF-α는 운동 직후 변화되지 않았으며, 모든 변인들에 있어 시기와 운동강도의상호작용효과는 나타나지 않았다. 최대산섭취량의 60%의중강도 운동 동안 아디포넥틴 농도의 변화는 렙틴 농도의변화와 유의한 상관관계가 있는 것으로 나타났다(r=-0.642,P<0.05). 결론: 일회성 유산소 운동은 비만 중년여성의 아디포넥틴 수치를 변화시키지 못하였다. 그러나 중강도 운동 시아디포넥틴 농도는 렙틴 농도의 변화와 관련성이 있는 것으로 생각한다.
Abstract
Background: Exercise intensity may induce changes in inflammatory markers and adipocytokines. However, it is not clear whether acute exercise-induced change to adiponenctin is associated with inflammatory markers and other adipocytokines in obese middle-aged individuals. The aim of this study was to investigate the effects of acute aerobic exercise on circulating adipocytokines and inflammatory markers in obese middle-aged women. MMethods: Using a crossover design, 10 obese middle-aged women (aged 48.4±5.1 years; body mass index 29.6±2.9 kg/m2) exercised on the treadmill at different durations and velocities at 60% and 80% maximum oxygen consumption (VO2max) in order to equalize energy expenditure (400 kcal). Blood samples were drawn to measure glucose, insulin, fibrinogen, high-sensitive C-reactive protein, leptin, tumor necrosis factor-α (TNF-α),and adiponectin concentrations. Results: Glucose, fibrinogen, and hsCRP increased significantly (P<0.05) after exercise whereas homeostasis model assessment-insulin resistance decreased significantly (P<0.05). Adiponectin, leptin, and TNF-α levels did not change significantly at immediate postexercise, and there were also no significant time × intensity interactions for all variables. The percentage change in adiponectin concentration from baseline to the end of exercise correlated with the percentage change in leptin concentration (r= -0.642, P<0.05) with 60% VO2max exercise. Conclusions: Our results indicated that, in obese middle-aged women, neither 60% nor 80% VO2max exercise alters adiponectin concentration, in spite of the changes to insulin resistance and inflammatory markers. However,after acute moderate exercise, adiponectin concentration may be associated with the change in leptin levels.
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