본문 바로가기
KERD
논문KCI 등재

12주 걷기 운동이 폐경 후 비만 여성의 식욕조절 호르몬, 아디포카인 및 인슐린 저항성에 미치는 영향

Effects of 12-weeks walking exercise on appetite regulating hormone, adipokine and insulin resistance in postmenopausal obesity women

2

조회

0

다운로드

13

인용

0

참고문헌

키워드

초록

본연구의 목적은 12주간의 걷기운동이 폐경 후 비만 여성의식욕조절 호르몬, 아디토카인 및 인슐린 저항성에 미치는 영향을 알아보는데 있다. 연구 대상자는 폐경 후 비만 여성 15명(체지방률; 30.8±1.6%, 체질량지수; 26.3±0.8)을 대상으로 하였으며, 운동 프로그램은 트레드밀 걷기 (하루 5 km, 6회/주, 12주)를 실시하였다. 연구 대상자는 운동 전·후 혈액을 채취하고, 혈중지질, 혈당, 인슐린, 렙틴, 그렐린, HOMA-IR, TNF-α을분석하였다. 그 결과 최대산소섭취량은 운동 후 유의하게 증가하였으며 (p<.05), 체지방률은 감소한 것으로 나타났다(p<0.05).혈당, 인슐린 및 HOMA-IR은 12주 5 km 걷기 후 유의하게 감소한 것으로 나타났다 (p<.05). 혈중 렙틴은 운동 후 유의하게 감소하였며 (p<.05), 혈중 그렐린은 12주 걷기 운동 후 유의하게 증가한 것으로 나타났다 (p<.05). 반면 TNF-α는 유의한 차이가 없는 것으로 나타났다. 이상 본 연 구결과를 종합해 보면, 폐경 후 비만 여성의 12주 5 km 걷기 운동은 체지방률감소와 함께 인슐린 저항성(혈당, 인슐린, HOMA-IR), 혈중 그렐린과 렙틴을 개선시키는데 효과가 있는 것을 알 수 있었다.

Abstract

The purpose of this study was to investigate the effects of 12-weeks walking exercise on appetite regulating hormone, adipokine and insulin resistance in postmenopausal obesity women. The 15 postmenopausal obesity women (%fat; 30.8±1.6%, BMI; 26.3±0.8) were volunteered for this study, and experimental exercise protocol was treadmill walking (5 km/day, 6 day/week, 12 weeks). Blood sample were drawn before and after 12 weeks exercise, and blood lipids, plasma glucose, insulin, leptin, ghrelin, HOMA-IR, TNF-α were measured. The maximal oxygen consumption was significantly increased after training (p<.05), and the %fat was significantly reduced after 12-weeks walking (p<.05). Plasma glucose, insulin levels and HOMA-IR were significantly reduced after 12-weeks 5 km walking (p<.05). Plasma leptin was significantly reduced after training (p<.05), and the plasma ghrelin levels was significantly increased after 12 weeks walking exercise (p<.05). TNF-α levels were not significantly changed after 12-weeks exercise. The results of this study indicate that 5 km walking exercise for 12 weeks significantly reduced %fat and attenuated insulin resistance. In addition, 5 km walking exercise of postmenopausal obesity women improved plasma leptin and ghrelin.

참고문헌 (53)

  1. 권유찬, "유산소와 근저항의 복합트레이닝이 비만중년여성의 복부지방 및 TNF-α에 미치는 영향", 한국체육학회지, 42(1), pp.563~572 (2003), 한국체육학회
  2. 김명수, "폐경 후 저강도 복합운동이 비만 중년여성의 신체조성, 혈중지질, 글루코스 및 렙틴에 미치는 효과", 한국사회체육학회지, (38), pp.951~960 (2009), 한국사회체육학회
  3. 김유섭, "규칙적인 유산소성 운동과 근저항성 운동을 병행한 복합운동이 폐경기 비만여성의 신체구성과 혈중 지질대사에 미치는 영향", 한국생활환경학회지, 12(4), pp.345~351 (2005), 한국생활환경학회
  4. 석민화, "저항운동이 폐경 전·후 비만여성의 신체구성, 골밀도 및 아디포사이토카인에 미치는 영향", 체육과학연구, 20(4), pp.693~703 (2009), 국민체육진흥공단 체육과학연구원
  5. 이석우, "폐경 후 여성에서 아디포카인과 비만 및 대사 합병증", Obstetrics & Gynecology Science, 52(12), pp.1204~1211 (2009), 대한산부인과학회
  6. 이석우, "폐경 후 여성에서 혈청 렙틴 농도와 대사증후군과의 관계", Obstetrics & Gynecology Science, 53(03), pp.254~263 (2010), 대한산부인과학회
  7. 장재훈, "걷기운동이 비만 여고생의 비만지표와 렙틴, 아디포넥틴 및 그렐린 농도에 미치는 영향과 상관성", 한국체육학회지, 46(3), pp.419~428 (2007), 한국체육학회
  8. 최웅환, "종설:지방세포와 아디포카인", 대한비만학회지, 11(2), pp.103~107 (2002)
  9. Ahima, R. S., "Adipose tissue as an endocrine organ", Trends Endocrinol Metab, 11(8), pp.327~332 (2000)
  10. Beasley, J. M., "Characteristics associated with fasting appetite hormones (obestatin, ghrelin, and leptin)", Obesity (SilverSpring), 17(2), pp.349~354 (2009)
  11. Briatore, L., "Acute plasma glucose increase, but not early insulin response, regulates plasma ghrelin", Eur J Endocrinol, 149(5), pp.403~406 (2003)
  12. Carr, M. C., "The emergence of the metabolic syndrome with menopause", J Clin Endocrinol Metab, 88(6), pp.2404~2411 (2003)
  13. Cederberg, H., "Unacylated ghrelin is associated with changes in body composition and body fat distribution during long-term exercise intervention", Eur J Endocrinol, 165(2), pp.243~248
  14. Chalkley, S. M., "Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats", Am J Physiol Endocrinol Metab, 282(6), pp.E1231~E1238 (2002)
  15. Chambers, J. C., "C-reactive protein, insulin resistance, central obesity, and coronary heart disease risk in Indian Asians from the United Kingdom compared with European whites", Circulation, 104(2), pp.145~150 (2001)
  16. Chu, M. C., "Insulin resistance in postmenopausal women with metabolic syndrome and the measurements of adiponectin, leptin, resistin, and ghrelin", Am J Obstet Gynecol., 194(1), pp.100~104 (2006)
  17. Clapp, J. F., 3rd, "Effects of pregnancy and exercise on concentrations of the metabolic markers tumor necrosis factor alpha and leptin", Am J Obstet Gynecol, 182(2), pp.300~306 (2000)
  18. De Souza, M. J., "Fasting ghrelin levels in physically active women:relationship with menstrual disturbances and metabolic hormones", J Clin Endocrinol Metab, 89(7), pp.3536~3542 (2004)
  19. Di Carlo, C., "Serum leptin levels in postmenopausal women:effects of transdermal hormone replacement therapy", Menopause, 7(1), pp.36~41 (2000)
  20. Elias, A. N., "Leptin and IGF-I levels in unconditioned male volunteers after short-term exercise", Psychoneuro endocrinology, 25(5), pp.453~461 (2000)
  21. Festa, A., "Chronic subclinical inflammation as part of the insulin resistance syndrome:the Insulin Resistance Atherosclerosis Study (IRAS)", Circulation, 102(1), pp.42~47 (2000)
  22. Foster-Schubert, K. E., "Human plasma ghrelin levels increase during a one-year exercise program", J Clin Endocrinol Metab, 90(2), pp.820~825 (2005)
  23. Friedenreich, C. M., "Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women", Endocr Relat Cancer, 18(3), pp.357~369 (2011)
  24. Ghanbari-Niaki, A., "Short-, moderate-, and long-term treadmill training protocols reduce plasma, fundus, but not small intestine ghrelin concentrations in male rats", J Endocrinol Invest, 34(6), pp.439~443
  25. Gnanapavan, S., "The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans", J Clin Endocrinol Metab, 87(6), pp.2988~ (2002)
  26. Goodpaster, B. H., "Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat", Diabetes, 46(10), pp.1579~1585 (1997)
  27. Guo, Z. F., "Different responses of circulating ghrelin, obestatin levels to fasting, re-feeding and different food compositions, and their local expressions in rats", Peptides, 29(7), pp.1247~1254 (2008)
  28. Jakubowicz, D., "Meal timing and composition influence ghrelin levels, appetite scores and weight loss maintenance in overweight and obese adults", Steroids, 77(4), pp.323~331 (2012)
  29. Kojima, M., "Ghrelin is a growth-hormone -releasing acylated peptide from stomach", Nature, 402(6762), pp.656~660 (1999)
  30. Kraemer, R. R., "Exercise and humoral mediators of peripheral energy balance:ghrelin and adiponectin", Exp Biol Med (Maywood), 232(2), pp.184~194 (2007)
  31. Kraemer, R. R., "Rigorous running increases growth hormone and insulin-like growth factor-I without altering ghrelin", Exp Biol Med (Maywood), 229(3), pp.240~246 (2004)
  32. Kraemer, R. R., "Ghrelin and other glucoregulatory hormone responses to eccentric and concentric muscle contractions", Endocrine, 24(1), pp.93~98 (2004)
  33. Kraemer, R. R., "Leptin and exercise", Experimental Biologyand Medicine, 227(9), pp.701~708 (2002)
  34. Laimer, M., "Markers of chronic inflammation and obesity:a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention", Int J Obes Relat Metab Disord, 26(5), pp.659~662 (2002)
  35. Lang, C. H., "Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output", Endocrinology, 130(1), pp.43~52 (1992)
  36. Leidy, H. J., "Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women", J Clin Endocrinol Metab, 89(6), pp.2659~2664 (2004)
  37. Li, J. B., "Effects of exercise on the levels of peptide YY and ghrelin", Exp Clin Endocrinol Diabetes, 119(3), pp.163~166 (2011)
  38. Li, R. Y., "Influence of visceral adiposity on ghrelin secretion and expression in rats during fasting", J Mol Endocrinol, 42(1), pp.67~74 (2009)
  39. Littman, A. J., "Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention", Int J Obes (Lond), 31(3), pp.466~475 (2007)
  40. Manshouri, M., "Time course alterations of plasma obestatin and growth hormone levels in response to short-term anaerobic exercise training in college women", Appl Physiol Nutr Metab, 33(6), pp.1246~1249 (2008)
  41. Martins, C, "The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat", J Clin Endocrinol Metab, 95(4), pp.1609~1616
  42. Morpurgo, P. S., "Ghrelin secretion in severely obese subjects before and after a 3-week integrated body mass reduction program", J Endocrinol Invest., 26(8), pp.723~727 (2003)
  43. Parente, E. B., "Obese children lipid profile:effects of hypocaloric diet and aerobic physical exercise", Arq Bras Endocrinol Metabol, 50(3), pp.499~504 (2006)
  44. Polak, J., "Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women", Metabolism, 55(10), pp.1375~1381 (2006)
  45. Reid, M. B., "Tumor necrosis factor-alpha and muscle wasting:a cellular perspective", Respir Res, 2(5), pp.269~272 (2001)
  46. Rigamonti, A. E., "Changes in plasma levels of ghrelin, leptin, and other hormonal and metabolic parameters following standardized breakfast, lunch, and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents", J Endocrinol Invest, 33(9), pp.633~639
  47. Ruan, H., "Insulin resistance in adipose tissue:direct and indirect effects of tumor necrosis factor-alpha", Cytokine Growth Factor Rev, 14(5), pp.447~455 (2003)
  48. Sowers, M., "Changes in body composition in women over six years at midlife: ovarian and chronological aging", J Clin Endocrinol Metab., 92(3), pp.895~901 (2007)
  49. Straczkowski, M., "Changes in tumor necrosis factor-alpha system and insulin sensitivity during an exercise training program in obese women with normal and impaired glucose tolerance", Eur J Endocrinol., 145(3), pp.273~280 (2001)
  50. Tuominen, J. A., "Leptin and thermogenesis in humans", Acta Physiol Scand., 160(1), pp.83~87 (1997)
  51. Villareal, D. T., "Physical frailty and body composition in obese elderly men and women", Obes Res., 12(6), pp.913~920 (2004)
  52. Wang, J., "Influence of shortand long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats", Endocrine, 33(1), pp.77~83 (2008)
  53. Zahorska-Markiewicz, B., "Effect of weight reduction on serum ghrelin and TNFalpha concentrations in obese women", Eur J Intern Med, 15(3), pp.172~175 (2004)

관련 논문AI추천

이 간행물의 다른 논문 (10건)