저항성 서킷트레이닝과 알로에 QDM 복합물 섭취가 중년 비만여성의 신체조성, 체력, 혈중지질 및 당뇨병 위험인자에 미치는 시너지효과: 무작위 이중맹검법
The Synergy Effect of Weight‐Bearing Circuit Training and Aloe QDM Complex on Obese Middle Aged Women: a Randomized Double‐Blind Controlled Trial
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연구배경: 비만은 전 세계 중요한 건강 문제 중 하나로제2형 당뇨, 인슐린저항성, 고혈압, 이상지질혈증 등의 대사증후군을 야기한다. 운동은 비만 관리를 위한 비약물적방법으로 권장되며, 특히 저항성 운동은 근육량을 증가시키고 체지방량을 감소시켜 비만인의 신체조성을 긍정적으로 개선시킨다. 하지만 이러한 운동에도 불구하고 비만인의 30% 경우 운동을 통한 비만 치료에 효과를 얻지 못해추가적인 치료 전략이 필요한 실정이다. 알로에 QDM 복합물은 알로에, 알로에신, 크롬의 복합영양물질로, 선행연구결과 알로에 QDM 복합물이 AMPK 신호기전을 향상시켜 인슐린 민감성을 증가시키고, 제2형 당뇨환자의 체중및 체지방량을 감소시켰다. 따라서 본 연구는 4주간의 저항성 서킷트레이닝과 알로에 QDM 복합물의 복합처치가중년 비만 여성의 신체조성, 체력, 혈중지질 및 당뇨병 위험인자에 미치는 시너지효과를 검증하는 데 목적이 있다. 방법: 본 연구는 무작위 이중맹검 연구로 운동군(Ex,n=9)과 복합군(Q-Ex, n=10)으로 분류하였다. 두 그룹 모두주 3회 저항성 서킷트레이닝을 실시했으며 알로에 QDM복합물과 위약을 1일 2회 복용하였다. 피험자들의 신체조성 변화를 확인하기 위해 에너지 방사선 흡수 계측기(dual-energy x-ray absorptiometry)로 체지방률과 제지방률을 측정하였으며, 체력 및 최대산소섭취량을 측정하였다. 또한 피험자의 혈중지질 및 당뇨병 위험인자의 변화를확인하기 위해 채혈하였다. 결과: 4주간의 저항성 서킷트레이닝과 알로에 QDM 복합물 섭취에 따른 운동군과 복합군의 체지방률(P=0.017)및체지방량(P=0.035)의 변화는 통계적으로 유의하였다. 특히운동군에서 체지방량(P=0.032)이 유의하게 감소하였고, 복합군에서는 체지방량(P<0.001)과 체지방률(P<0.001) 모두유의하게 감소하였다. 반면 체력요인과 혈중 지질 및 당뇨병 위험인자에서는 통계적으로 유의한 변화가 나타나지않았다. 결론: 4주간의 저항성 서킷트레이닝과 저항성 서킷트레이닝과 알로에 QDM 복합물 복합처치는 중년 비만 여성의체지방률 및 체지방량을 감소시키는 실효성이 있는 연구 결과를 제시함으로써 운동과 영양의 시너지효과가 비만을 개선하는 데 긍정적으로 영향을 미칠 것으로 기대한다.
Abstract
Background: Obesity is a major health problem and leads to metabolic diseases such as type 2 diabetes, insulin resistance and hyperlipidemia. Recently, it was reported that aloe QDM complex, composed of processed aloe vera gel, aloesin and chromiun could improve insulin sensitivity by enhancing 5' adenosine monophosphate- activated protein (AMPK) activity and has an anti-inflammatory effect by reducing the level of pro-inflammatory cytokines. It is also known that aloe QDM complex can reduce body weight, body fat mass and insulin resistance in type 2 diabetes patients. The purpose of this study was to assess for possible synergistic effects of weight-bearing circuit training and aloe QDM complex supplementation on body composition, physical fitness, blood profile and diabetes risk factors. Methods: Study subjects included 19 participants randomly assigned to the Exercise group (Ex, n=9) and to the Exercise with aloe QDM complex group (Q-Ex, n=10). Both groups participated in weight-bearing circuit training 3 times a week for 4 weeks and took a capsule composed of either aloe (aloe QDM complex) or soy bean (placebo), 1100 mg/day for 4 weeks. Body composition was measured by dual-energy x-ray absorptiometry. Grip strength, flexibility, curl-up, balance, agility, Sargent jump and VO2max were measured, as well as fasting blood samples taken. Results: After 4 weeks of weight-bearing circuit training and aloe QDM complex supplementation, the significant interactions (time × intervention) between the groups regarding body fat percentage (F=7.024, P=0.017) and body fat mass (F=5.243, P=0.035) were calculated. There were significant differences in body fat percentage (P=0.029) and body fat mass (P=0.039). No significant interaction was observed in physical fitness, blood profile and diabetes risk factors. Conclusions: In this study, the combination of weight-bearing circuit training and aloe QDM complex supplementation showed a positive effect for reducing body fat mass, and could be an effective intervention for managing obesity.
참고문헌 (28)
- "National Health and Nutrition Survey 2011. Korea Health Statistics 2011: Korea National Health and Nutrition Examination Survey(KNHANESV‐2)" (2012)[URL]
- Klein S, "Weight management through lifestyle modification for the prevention and management of type 2 diabetes:rationale and strategies: a statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition", Diabetes Care, 27(8), pp.2067~2073 (2004)
- American College of Sports Medicine, "ACSM’s Guidelines for Exercise Testing and Prescription", pp.19~219 (2006), Lippincott Williams & Wilkins
- Hunter GR, "Resistance training and intra-abdominal adipose tissue in older men and women", Med Sci Sports Exerc, 34(6), pp.1023~1028 (2002)
- Booth FW, "America needs to exercise for health", Med Sci Sports Exerc, 27(3), pp.462~465 (1995)
- Most J, "Short-term supplementation with a specific combination of dietary polyphenols increases energy expenditure and alters substrate metabolism in overweight subjects", Int J Obes (Lond), 38(5), pp.698~706 (2014)
- Capasso F, "Aloe and its therapeutic use", Phytother Res, 12(S1), pp.S124~S127 (1998)
- Heggers JP, "Wound healing effects of Aloe gel and other topical antibacterial agents on rat skin", Phytother Res, 9(6), pp.455~457 (1995)
- Koo MW, "Aloe vera: antiulcer and antidiabetic effects", Phytother Res, 8(8), pp.461~464 (1994)
- Winters WD, "Effects of aloe extracts on human normal and tumor cells in vitro", Econ Bot, 35(1), pp.89~95 (1981)
- Ngo MQ, "Oral aloe vera for treatment of diabetes mellitus and dyslipidemia", Am J Health Syst Pharm, 67(21), pp.1804~1811 (2010)
- Langmead L, "Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis", Aliment Pharmacol Ther, 19(7), pp.739~747 (2004)
- Yongchaiyudha S, "Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus", Phytomedicine, 3(3), pp.241~243 (1996)
- Bunyapraphatsara N, "Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide", Phytomedicine, 3(3), pp.245~248 (1996)
- Misawa E, "Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats", Obes Res Clin Pract, 2(4), pp.239~245 (2008)
- Choi HC, "Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial", Nutrition, 29(9), pp.1110~1114 (2013)
- 신은주, "Dietary Aloe Reduces Adipogenesis via the Activation of AMPK and Suppresses Obesity-related Inflammation in Obese Mice", Immune Network, 11(2), pp.107~113 (2011), 대한면역학회
- Mu J, "A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle", Mol Cell, 7(5), pp.1085~1094 (2011)
- Reznick RM, "The role of AMP-activated protein kinase in mitochondrial biogenesis", J Physiol, 574(Pt 1), pp.33~39 (2006)
- O'Neill HM, "AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity", Mol Cell Endocrinol, 366(2), pp.135~151 (2013)
- American College of Sports Medicine, "ACSM’s Guidelines for Exercise Testing and Prescription", pp.320~ (2014), Lippincott Williams & Wilkins Health
- 신은주, "Dietary Aloe Improves Insulin Sensitivity via the Suppression of Obesity-induced Inflammation in Obese Mice", Immune Network, 11(1), pp.59~67 (2011), 대한면역학회
- 소위영, "걷기 운동과 저항성 운동이 비만중년여성의 신체조성, 심폐순환기능, 체력 및 혈중에 미치는 영향", 운동과학, 16(2), pp.85~94 (2007), 한국운동생리학회
- 권용일, "복합운동 트레이닝이 비만 남자중학생의 체력과 대사증후군에 미치는 효과", 한국체육학회지, 45(6), pp.611~622 (2006), 한국체육학회
- Watts K, "Exercise training in obese children and adolescents: current concepts", Sports Med, 35(5), pp.375~392 (2005)
- Swain DP, "Moderate or vigorous intensity exercise: which is better for improving aerobic fitness?", Prev Cardiol, 8(1), pp.55~58 (2005)
- Olson TP, "Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women", Int J Obes (Lond), 31(6), pp.996~1003 (2007)
- Ibáñez J, "Resistance training improves cardiovascular risk factors in obese women despite a significative decrease in serum adiponectin levels", Obesity (Silver Spring), 18(3), pp.535~541 (2010)