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제5기 국민건강영양조사 자료 중 성인 남성에서 비타민 D와 고밀도 지단백 콜레스테롤의 관련성

Association between High-Density Lipoprotein Cholesterol and Vitamin D Levels in Adult Men in the Fifth Korea National Health and Nutrition Examination Survey

정인경
대한임상건강증진학회 (Korean Society For Health Promotion And Disease Prevention)|2019.12|Korean Journal of Health Promotion|제19권 제4호|pp. 210-220

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키워드

Life style대사증후군생활습관Metabolic syndromeVitamin D비타민 DHDL-cholesterol고밀도 지단백 콜레스테롤
주제분류기타자연과학

초록

연구배경: 대사증후군 환자의 경우 혈중 고밀도 지단백 콜레스테롤(HDL-C)이 낮으며 비타민 D 농도가 낮은 경우도대사증후군과 관련이 있다고 한다. 본 연구는 비타민 D와HDL-C와의 관련성을 조사하고자 하였다. 방법: 제5기 국민건강영양조사에 참여한 20세 이상의 성인 남성 중 연구변수에 결측치가 없는 5,537명을 대상으로비타민 D와 저HDL-C혈증의 관련성을 연구하였다. 비타민D와 HDL-C의 농도에 영향을 주는 것으로 알려진 나이, 체질량지수(BMI), 사회경제적 지표 및 생활습관의 영향을 단계적으로 보정하며 로지스틱 회귀분석으로 확인하였다. 결과: 20세 이상의 한국 남성에서 비타민 D는 18.3±0.2 ng/mL, HDL-C는 46.8±0.2 mg/dL였으며 저HDL-C혈증유병률은 29.2±0.8%였다. 나이, BMI, 사회경제적 지표 및생활습관의 영향을 보정한 후 비타민 D와 저HDL-C혈증의 관련성을 로지스틱 회귀분석으로 조사한 결과 비타민 D제3사분위군을 기준으로 제1사분위군은 1.296배(95% CI, 1.035-1.623), 제2사분위는 1.354배(95% CI, 1.086-1.690) 였다. 결론: 성인 남성에서 나이, BMI, 사회경제적 지표 및 생활습관의 영향을 보정 후 저HDL-C혈증의 유병 가능성은 비타민 D의 농도와 유의한 관련성이 있었다.

Abstract

Background: Patients with metabolic syndrome had low high-density lipoprotein cholesterol (HDL-C) levels. Moreover, vitamin D deficiency is also related to metabolic syndrome. This study aimed to investigate the association between vitamin D and HDL-C levels. Methods: To determine the association between HDL-C and vitamin D levels, 5,537 males who had no missing values were systematically selected from the fifth Korea National Health and Nutrition Examination Survey. Then, the association was investigated by a multivariable logistic regression analysis after adjusting for the effects of confounding factors on vitamin D and HDL-C levels, such as age, body mass index (BMI), sociodemographic factors, and lifestyle factors. Results: In Korean men aged ≥20 years, the mean vitamin D and HDL-C levels were 18.3±0.2 ng/mL and 46.8±0.2 mg/dL, respectively. Moreover, the prevalence of low HDL-C levels was 29.2±0.8%. After adjusting for age, BMI, sociodemographic factors, and lifestyle factors, the risk of low HDL-C levels in the lowest quartile of vitamin D level was 1.296 (95% confidence interval [CI], 1.035-1.623) times higher and that in the second quartile of vitamin D level was 1.354 (95% CI, 1.086-1.690) times higher than that in the third quartile of vitamin D level (P<0.05). Conclusions: The risk of low HDL-C levels is associated with vitamin D level after adjustment for age, BMI, sociodemographic factors, and lifestyle factors.

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