폐기능과 요산 수치와의 관련성
The Relationship between Pulmonary Function and Serum Uric Acid Level in the Korean Population
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연구배경: 강제폐활량과 1초간 강제호기량 등은 폐기능의지표로 측정된다. 또한 요산 수치는 통풍과 심혈관 질환의위험요인이다. 본 연구에서는 한국인 남성과 여성에서 폐기능과 요산 수치와의 관련성을 분석하였다. 방법: 연구 대상자는 2016년 국민건강영양조사에 참여한3,411명의 성인이다. 남성 1,500명, 여성 1,911명이 분석에포함되었다. 결과: 여성에서 폐기능과 요산 수치와의 음의 상관성을 보였다. 남성의 경우에는 비흡연자에서 폐기능과 요산과의 통계학적으로 유의한 음의 상관성이 있었다. 남성에서의 1초간 강제호기량이 낮은 사람은 1초간 강제호기량이 높은 사람들에 비해서 고요산혈증과 유의한 관련성이 있었다. 여성에서도 강제폐활량이 낮은 사람은 강제폐활량이 높은 사람들에 비하여 고요산혈증과 유의한 관련성이 있었다. 결론: 본 연구에서 고요산혈증은 남성과 여성 모두에서낮은 폐기능과 관련이 있었다. 인과관계를 더 정확히 알기위해서는 추후 전향적인 코호트 연구가 필요하겠다.
Abstract
Background: Forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and the ratio of FEV1 to FVC (FEV1/FVC) are considered as the major spirometry parameters. Serum uric acid is associated with increased risk of gout and cardiovascular disease. We analyzed the relationship between pulmonary function and serum uric acid level in the Korean men and women. Methods: This study was based on the data collected during the 2016 Korea National Health and Nutrition Examination Survey (KNHANES VII-1). A total of 3,411 adults were retrieved from KNHANES VII-1. Among 3,411 adults, 1,500 were men and 1,911 were women. Results: In this study, a significant negative correlation was observed between serum uric acid level and pulmonary function values only in females. Also, in the male non-smoker group, pulmonary function values were negatively associated with serum uric acid level (FVC %predicted, β=-0.014; FEV1 %predicted, β=-0.015). Conclusions: In this study, hyperuricemia was associated with the low lung function in males and females. In order to obtain an accurate assessment of the association between hyperuricemia and pulmonary function values, further prospective cohort study in the future is necessary.
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