두 종류의 스펙트럼영역 빛간섭단층촬영기를 사용한 정상 한국인의 맥락막 두께 측정의 재현성
Reproducibility of Choroidal Thickness in Normal Korean Eyes Using Two Spectral Domain Optical Coherence Tomography
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목적: 두 종류(Cirrus, Spectalis)의 스펙트럼영역 빛간섭단층촬영기(Optical coherence tomography, OCT)를 사용하여 건강한 한국성인의 맥락막 두께를 측정하고, 두 기계간의 재현성 및 측정자간의 재현성을 비교하였다. 대상과 방법: 안과적 이상이 없는 정상 성인 30명의 60안을 대상으로, Cirrus OCT의 1-line raster 및 Spectialis OCT의 Enhanced depth imaging을 사용하여 맥락막을 검사하였고, 맥락막 두께는 독립된 두 측정자가 중심와 아래, 1.5 mm 비측, 1.5 mm 이측에서측정하였다. 결과: 총 검사 대상자는 30명이었으며 남성 15명, 여성 15명으로 평균 연령은 50.73 ± 15.09세(24-75세)였다. 두 기계간에서 측정한맥락막 두께는 통계적으로 차이를 보이지 않았으며 강한 상관관계를 보였다. Bland-Altman plot에서 bias는 관찰되지 않았다. 두 측정자간의 재현성도 우수하였다. 결론: 정상 한국인의 맥락막 두께 측정에 대한 Cirrus 및 Spectralis OCT의 재현성은 우수하였다.
Abstract
Purpose: To investigate the reproducibility of choroidal thickness measurements in healthy Koreans using two spectral domain optical coherence tomography (SD-OCT) instruments: Zeiss Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA,USA) and Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany). Methods: Images were obtained in 60 eyes of 30 healthy undilated volunteers without ocular pathology in a clinical setting. The choroid was imaged in all subjects using Cirrus HD 1-line raster and Spectralis enhanced depth imaging (EDI). The choroid was measured subfoveally, 1500 μm temporal, and 1500 μm nasal to the fovea. All measurements were performed by two independent observers. One-way analysis of variance (ANOVA), Pearson correlation, and Bland–Altman analysis were used to compare measurements. Results: The study group consisted of 15 males and 15 females. The mean age was 50.73 ± 15.09 years (range, 24-75years). There was no significant difference in the mean choroidal thickness (p > 0.05) between systems for any location. The choroidal thickness measurements using two instruments (Cirrus vs. Spectralis) were also strongly correlated (p <0.001). Conclusions: In the present study of healthy Korean adults, good reproducibility was observed between choroidal thickness measurements of images obtained from Cirrus and Spectralis.
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