스펙트럼영역 빛간섭단층촬영기를 이용하여 관찰한정상소아에서 후극부 맥락막의 형태
The Posterior Choroidal Profiles Measured by Spectral Domain Optical Coherence Tomography in Healthy Korean Children
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목적: 빛간섭단층촬영기 Enhanced depth imaging (EDI) 방법으로 측정한 정상 소아의 후극부 맥락막두께의 변화를 알아보고 안축장과 맥락막두께 사이의 상관관계를 평가하였다. 대상과 방법: 구면렌즈대응치가 ±1 디옵터 이내인 79명 79안을 대상으로 EDI 방법으로 후극부의 수평과 수직단면을 검사하였다. 맥락막두께측정은 두 관찰자가 중심와의 위쪽 아래쪽 1 mm 지점 및 코쪽 3 mm부터 귀쪽 4 mm까지 1 mm 간격으로 내장된 캘리퍼로측정하였다. 통계적 분석은 망막의 각 지점의 맥락막두께의 변화를 분석하였고, 안축장과 맥락막두께 사이의 상관관계를 평가하였다. EDI측정법의 재현성을 알아보기 위해 유목내상관계수를 구하였다. 결과: 평균 나이는 7.67세, 평균 안축장은 22.96 mm였고, 평균맥락막두께는 중심와에서 296.13 μm였다. 중심와 코쪽 3 mm지점에서160.57 μm로 가장 얇았고, 귀쪽 4 mm 지점에서 319.49 μm로 가장 두꺼웠다(p＜0.05). 중심와 상측과 하측 1 mm에서는 각각 294.70 μm,287.11 μm로 중심와와 차이가 없었다. 평균 안축장보다 짧은 눈에서 코쪽 3 mm와 2 mm의 맥락막두께는 의미있게 두꺼웠다(p＜0.05). 두 검사자간 유목내상관계수는 0.995 이상이었다. 결론: 정상 소아에서 후극부의 맥락막두께는 코쪽에서 귀쪽으로 두꺼워지고 짧은 안축장을 가진 눈은 코쪽 맥락막두께가 더 두꺼운경향을 보인다.
Abstract
Purpose: We assessed changes of the choroidal thickness in healthy Korean children using enhanced depth imaging (EDI) optical coherence tomography (OCT) and evaluated the association of choroidal thickness and axial length. Methods: Seventy-nine eyes (79 children) within ±1 diopter spherical equivalent underwent horizontal and vertical scan using EDI OCT. Two observers determined independently the choroidal thickness at 1 mm intervals from 3 mm nasal and 4 mm temporal to the fovea and 1 mm superior and inferior to the fovea using the manual caliper provided by the device software. Statistical analysis was performed to evaluate variations of choroidal thickness at each location and to correlate choroidal thickness and axial length. Intraclass correlation coefficient (ICC) was calculated. Results: The subjects’ mean age was 7.67 years. The mean axial length was 22.96 mm and mean subfoveal choroidal thickness was 296.13 μm. The thinnest choroidal thickness was 160.57 μm at 3 mm nasal to the fovea and the thickest was 319.49 μm at 4 mm temporal to the fovea. The choroidal thickness at 1 mm superior (294.70 μm) and inferior (287.11 μm)to the fovea showed no statistical significance compared with the subfoveal choroidal thickness. The mean choroidal thickness was thicker at 3 mm and 2 mm nasal to the fovea in eyes with shorter than the mean axial length (p < 0.05). For the assessment of intra-observer reproducibility, the ICC ranged from 0.995 to 0.998 (p < 0.001). Conclusions: The choroidal thickness increased from the nasal to the temporal direction at the posterior pole and eyes with shorter axial lengths tended to present thicker choroids at the nasal area in healthy Korean children.
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