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혈류제한 저강도 근력 트레이닝이 노인 여성의 혈중 VEGF 농도, 골대사 지표 및 골밀도에 미치는 영향

Effect of low-intensity resistance training with blood flow restriction on serum VEGF level, bone markers and bone mineral density in elderly women

안지영|윤성진|이진석|박수빈|손왕국
국민체육진흥공단 한국스포츠과학원 (Korea Institute of Sport Science)|2019.09|체육과학연구 (Korean Journal of Sport Science)|제30권 제3호|pp. 459-469|DOI 10.24985/kjss.2019.30.3.459

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키워드

VEGF골밀도Bone mineral density노인 여성Bone marker혈류제한 저강도 근력 트레이닝가압트레이닝골대사 지표Blood flow restriction trainingLow–intensity resistance training
주제분류체육

초록

[목적] 이 연구의 목적은 노인 여성을 대상으로 혈류제한 저강도 근력 트레이닝이 혈중 VEGF 농도, 골대사 지표 및 골밀도에 미치는 영향을 검증하는데 있다. [방법] 이 연구에서는 65세 이상 노인 여성 27명을 연구대상자로 모집하였으며, 연구대상자들은 혈류 제한 저강도 근력 트레이닝 집단(BFR󰠏LRT, n=8), 고강도 근력 트레이닝 집단(HRT, n=8), 저강도 근력 트레이닝 집단(LRT, n=5)으로 무작위 분류되었다. 트레이닝은 세 집단 모두 12주간 주3회 knee extension과 leg curl 운동을 하였으며, BFR󰠏LRT 집단은 혈류제한과 함께 최대근력의 20% 운동 강도, LRT 집단은 최대근력 20%의 운동 강도, HRT 집단은 최대근력의 70% 강도로 운동하도록 하였다. [결과] 연구 결과, 12주의 트레이닝 기간 후 VEGF 농도는 BFR󰠏LRT 집단이 HRT, LRT 집단과 비교하여 유의하게 증가하였다(P<.05). 혈청 Bone ALP 농도는 BFR󰠏LRT, LRT 집단이 LRT 집단과 비교하여 유의하게 증가하였다(P<.05). T-score 점수는 BFR󰠏LRT, HRT 집단이 LRT 집단과 비교하여 유의하게 증가하였다(P<.05). [결론] 결론적으로, 혈류제한 저강도 근력 트레이닝은 노인 여성의 골대사 지표 개선에 효과적임을 증명함으로써 혈류제한 저강도 근력 트레이닝은 고강도 근력 트레이닝을 대처할 수 있는 효율적인 운동 방법의 하나가 될 수 있을 것으로 생각된다.

Abstract

[Purpose] The purpose of this study was to investigate the effects of low󰠏intensity resistance training with blood flow restriction on serum VEGF, bone markers and bone mineral density in elderly women. [Methods] The subjects were divided into three groups: low-intensity resistance training with blood flow restriction(BFR󰠏LRT, n=8); high intensity resistance training(HRT, n=8); low- intensity resistance training (LRT, n=5). Both the BFR󰠏LRT and LRT groups worked out knee extension and leg curl exercises at 20% of each estimated one󰠏repetition maximum(1RM) and HRT group worked out knee extension and leg curl exercises at 70% of each estimated 1RM 3 days per week for 12 weeks. [Results] As a result after 12 weeks, serum VEGF level have increased significantly among BFR󰠏LRT group compared to HRT and LRT groups. Serum Bone ALP level have increased significantly among BFR󰠏LRT and HRT groups compared to LRT group. Calcaneus BMD have increased significantly among BFR󰠏LRT and HRT groups compared to LRT group. [Conclusions] In conclusion, despite using low-intensity load, BFR󰠏LRT is a efficient training alternative to HRT for improving bone metabolism in older women.

참고문헌 (44)

  1. Abe, T., "Skeletal muscle size and circulating IGF-1 are increased after two weeks of twice daily"KAATSU"resistance training", International Journal of KAATSU Training Research, 1(1), pp.6~12 (2005)
  2. Beekley, M. D., "KAATSU-walk training increases serum bone-specific alkaline phosphatase in young men", International Journal of KAATSU Training Research, 1(2), pp.77~81 (2005)
  3. Brzycki, M., "Strength testing—predicting a one-rep max from reps-to-fatigue", Journal of Physical Education, Recreation & Dance, 64(1), pp.88~90 (1993)
  4. Cho, E. M., "Analysis of correlation between parameters by QUS(Quantitative Ultrasound)and bone mineral density by DEXA(Dual-enrgy X-ray absorptiometey)", Journal of Menopausal Medicine, 3, pp.171~177 (1997)
  5. Das, B. G., "Prevalence and risk factors of osteopenia and osteoporosis in Indian women", IOSR Journal of Dental and Medical Sciences vol, 15, pp.15~18 (2016)
  6. Dev, R. O., "Effects of body mass index(BMI), eating attitude and physical activity on bone health among undergraduate students in Malaysia", International E-Journal of Advances in Social Sciences, 2(5), pp.591~597 (2016)
  7. Downs, M. E., "Acute vascular and cardiovascular responses to blood flow-restricted exercise", Medicine and science in sports and exercise, 46(8), pp.1489~1497 (2014)
  8. Drummond, M. J., "Human muscle gene expression following resistance exercise and blood flow restriction", Medicine and science in sports and exercise, 40(4), pp.691~ (2008)
  9. Fujimura, R., "Effect of resistance exercise training on bone formation and resorption in young male subjects assessed by biomarkers of bone metabolism", Journal of Bone and Mineral Research, 12(4), pp.656~662 (1997)
  10. Grisso, J. A., "Risk factors for falls as a cause of hip fracture in women", New England journal of medicine, 324(19), pp.1326~1331 (1991)
  11. HIRA, "Health Insurance Review Assessment Service", ~ (2015)
  12. Jacobsen, K. A., "Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling", Journal of Bone and Mineral Research, 23(5), pp.596~609 (2008)
  13. Jilka, R. L., "Increased osteoclast development after estrogen loss : mediation by interleukin-6", Science, 257(5066), pp.88~91 (1992)
  14. Karabulut, M., "The effects of low-intensity resistance training with vascular restriction on leg muscle strength in older men", European journal of applied physiology, 108(1), pp.147~155 (2010)
  15. Karabulut, M., "Effects of high-intensity resistance training and low-intensity resistance training with vascular restriction on bone markers in older men", European journal of applied physiology, 111(8), pp.1659~1667 (2011)
  16. Karabulut, M., "The effects of different initial restrictive pressures used to reduce blood flow and thigh composition on tissue oxygenation of the quadriceps", Journal of sports sciences, 29(9), pp.951~958 (2011)
  17. Kim, S., "Effects of short term low intensity resistance training with blood flow restriction on bone markers and muscle cross-sectional area in young men", International Journal of Exercise Science, 5(2), pp.6~ (2012)
  18. 김명희, "중년 여성의 골밀도와 신체적, 산과적 특성과의 관계 연구", 성인간호학회지, 14(4), pp.532~542 (2002), 한국성인간호학회
  19. Kohrt, W. M., "Monitoring metabolic status: Predicting Decrements in Physiological and Cognitive Performance", pp.45~ (2004)
  20. Larkin, K. A., "Blood flow restriction enhances post–resistance exercise angiogenic gene expression", Medicine and science in sports and exercise, 44(11), pp.2077~ (2012)
  21. Loenneke, J. P., "Blood flow restriction : rationale for improving bone", Medical hypotheses, 78(4), pp.523~527 (2012)
  22. Lester, M. E., "Influence of exercise mode and osteogenic index on bone biomarker responses during short-term physical training", Bone, 45(4), pp.768~776 (2009)
  23. Lowery, R. P., "Practical blood flow restriction training increases muscle hypertrophy during a periodized resistance training programme", Clinical physiology and functional imaging, 34(4), pp.317~321 (2014)
  24. Marques, E. A., "Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women", Archives of gerontology and geriatrics, 57(2), pp.226~233 (2013)
  25. Mayer, H., "Vascular endothelial growth factor(VEGFA)expression in human mesenchymal stem cells : autocrine and paracrine role on osteoblastic and endothelial differentiation", Journal of cellular biochemistry, 95(4), pp.827~839 (2005)
  26. Miyachi, M., "Effects of resistance training on arterial stiffness : a meta-analysis", British Journal of Sports Medicine, 47(6), pp.393~396 (2013)
  27. Mosti, M. P., "Maximal strength training in postmenopausal women with osteoporosis or osteopenia", The Journal of Strength &Conditioning Research, 27(10), pp.2879~2886 (2013)
  28. NHIS, "National Health Insurance Service", ~ (2015)
  29. Okamoto, T., "Effects of muscle contraction timing during resistance training on vascular function", Journal of human hypertension, 23(7), pp.470~ (2009)
  30. Pollock, M. L., "Injuries and adherence to walk", jog and resistance training programs in the elderly, 1991, pp.23(10), 1194~1200
  31. Riggs, B. L., "A unitary model for involutional osteoporosis : estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men", Journal of bone and mineral research, 13(5), pp.763~773 (1998)
  32. Schipani, E., "Regulation of osteogenesis‐angiogenesis coupling by HIFs and VEGF", Journal of bone and mineral research, 24(8), pp.1347~1353 (2009)
  33. Senel, K., "Circulating vascular endothelial growth factor concentrations in patients with postmenopausal osteoporosis", Archives of Medical Science, 9(4), pp.709~712 (2013)
  34. Shimizu, R., "Low-intensity resistance training with blood flow restriction improves vascular endothelial function and peripheral blood circulation in healthy elderly people", European journal of applied physiology, 116(4), pp.749~757 (2016)
  35. Shin, M. H., "Quantitative ultrasound for osteoporosis screening in postmenopausal women", Journal of Preventive Medicine and Public Health, 34(4), pp.408~416 (2001)
  36. Tajima, O., "Interaction of the effects between vitamin D receptor polymorphism and exercise training on bone metabolism", Journal of applied physiology, 88(4), pp.1271~1276 (2000)
  37. Takada, S., "Blood flow restriction exercise in sprinters and endurance runners", Medicine &Science in Sports & Exercise, 44(3), pp.413~419 (2012)
  38. Takarada, Y., "Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans", Journal of applied physiology, 88(6), pp.2097~2106 (2000)
  39. Tanimoto, M., "Muscle oxygenation and plasma growth hormone concentration during and after resistance exercise : Comparison between"KAATSU"and other types of regimen", International Journal of KAATSU Training Research, 1(2), pp.51~56 (2005)
  40. Vincent, K. R., "Resistance exercise and bone turnover in elderly men and women", Medicine and science in sports and exercise, 34(1), pp.17~23 (2002)
  41. Watson, S. L., "Heavy resistance training is safe and improves bone, function, and stature in postmenopausal women with low to very low bone mass : novel early findings from the LIFTMOR trial", Osteoporosis International, 26(12), pp.2889~2894 (2015)
  42. Yamazaki, S., "Effect of walking exercise on bone metabolism in postmenopausal women with osteopenia", osteoporosis, 2004, pp.22(5), 500~508
  43. Yasuda, T., "Muscle size and arterial stiffness after blood flow‐restricted low‐intensity resistance training in older adults", Scandinavian journal of medicine & science in sports, 24(5), pp.799~806 (2014)
  44. 유지민, "혈류제한 근력 트레이닝 시 휴식시간의 차이가 혈중 호르몬농도와 근력에 미치는 영향", 한국체육학회지, 47(6), pp.645~658 (2008), 한국체육학회

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