방사선 손상 Balb/C 마우스 모델에서 누에 체액(Silkworm Hemolymph)의 간조직 보호 효과
Protective Effect of Silkworm Hemolymph against Gamma Irradiation Induced Damage in the Liver of Mice
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This study was designed to evaluate the protective effect of silkworm hemolymph againstγ-irradiation induced damage in the liver of mice. Female Balb/C mice (6 weeks old) were exposedto γ-irradiation (6 Gy) and administered orally to silkworm hemolymph (5 ml kg-1 BW) for 7 dayspost-irradiation. The body weight, spleen index, plasma aspartate transaminase (AST), plasmaalanine transaminase (ALT), and liver malondialdehyde (MDA) levels were determined. Comparedwith irradiated control mice, the activity of plasma AST and the level of MDA were significantlydecreased in mice treated silkworm hemolymph. These results show that silkworm hemolymph isfound to have a protective effect against γ-irradiation induced damage in mice.
Abstract
This study was designed to evaluate the protective effect of silkworm hemolymph againstγ-irradiation induced damage in the liver of mice. Female Balb/C mice (6 weeks old) were exposedto γ-irradiation (6 Gy) and administered orally to silkworm hemolymph (5 ml kg-1 BW) for 7 dayspost-irradiation. The body weight, spleen index, plasma aspartate transaminase (AST), plasmaalanine transaminase (ALT), and liver malondialdehyde (MDA) levels were determined. Comparedwith irradiated control mice, the activity of plasma AST and the level of MDA were significantlydecreased in mice treated silkworm hemolymph. These results show that silkworm hemolymph isfound to have a protective effect against γ-irradiation induced damage in mice.
참고문헌 (19)
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