장기 중선량률 감마선 피폭에 의한 마우스의 생존율 및생물학적 영향 평가
Survival Rate and Biological Effect of Chronic Medium-Dose-Rate Gamma Radiation Exposed to Mice
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Late effects of chronic exposure to gamma radiation are potential hazards to workerin radiation facilities as well as to the general public. Recently, chronic gamma radiation exposureeffects have become a serious concern. Using a total of 60 mice, we studied the biological effects ofmedium-dose chronic exposure to gamma radiation. Sixty female 6-week-old specific pathogenfree Balb/c mice were randomly divided into six groups (five groups irradiated and one non-irradiatedcontrol group). Irradiation was carried out for 7 days using gamma rays at dose rates of119.65, 238.10, 357.14, 476.19 and 595.24 mGy h-1 with total doses 20, 40, 60, 80 and 100 Gy. Afterirradiation, we determined survival rate of gamma radiation exposed mice during 1 week and476.19 and 595.24 mGy h-1 exposed group mice showed less 10% of survival rate. Otherwise,119.65, 238.10 and 357.14 mGy h-1 exposed group mice were survived each 100%, 80% and 70%. Half of survived mice after 1 week are immediately sacrifice and counted body and spleen weights. Compared with control non-irradiated group, total body weights and spleen weights isolated from119.65, 238.10 and 357.14 irradiated group mice showed significant decreased. However, no significantalteration was observed between 119.65, 238.10 and 357.14 mGy h-1 irradiated group. Overall, our results show for the first time that medium-dose chronic gamma radiation has thepotential to stimulation of biological effects.
Abstract
Late effects of chronic exposure to gamma radiation are potential hazards to workerin radiation facilities as well as to the general public. Recently, chronic gamma radiation exposureeffects have become a serious concern. Using a total of 60 mice, we studied the biological effects ofmedium-dose chronic exposure to gamma radiation. Sixty female 6-week-old specific pathogenfree Balb/c mice were randomly divided into six groups (five groups irradiated and one non-irradiatedcontrol group). Irradiation was carried out for 7 days using gamma rays at dose rates of119.65, 238.10, 357.14, 476.19 and 595.24 mGy h-1 with total doses 20, 40, 60, 80 and 100 Gy. Afterirradiation, we determined survival rate of gamma radiation exposed mice during 1 week and476.19 and 595.24 mGy h-1 exposed group mice showed less 10% of survival rate. Otherwise,119.65, 238.10 and 357.14 mGy h-1 exposed group mice were survived each 100%, 80% and 70%. Half of survived mice after 1 week are immediately sacrifice and counted body and spleen weights. Compared with control non-irradiated group, total body weights and spleen weights isolated from119.65, 238.10 and 357.14 irradiated group mice showed significant decreased. However, no significantalteration was observed between 119.65, 238.10 and 357.14 mGy h-1 irradiated group. Overall, our results show for the first time that medium-dose chronic gamma radiation has thepotential to stimulation of biological effects.
참고문헌 (7)
- "Atomic Knowledge Information Protal"[URL]
- 도경현, "저선량 방사선이 인체에 미치는 영향", 대한의사협회지, 54(12), pp.1253~1261 (2011), 대한의사협회
- ICRP, "The 2007 recommendations of the international commission on radiological protection, Publication 103", ~ (2007)
- National Research Council (US), "Health risks from exposure to low levels of ionizing radiation:BEIR VII pahse 2" (2005), National Academies Press
- Tanaka K, "Dose-rate effects and dose and dose-rate effectiveness factor on frequencies of chromosome aberrations in splenic lymphocytes from mice continuously exposed to low-dose-rate gamma-radiation", J. Radiol. Prot, 33, pp.61~70 (2013)
- Report of the United Nations scientific on the effects of atomic radation, "Unites Nations Scientific Committee on the Effects of Atomic Radiation", United Nations, ~ (2010)
- Zeitlin C, "Measurements of Energetic Particle Radiation in Transit to Mars on the Mars Science Laboratory", Science, 340, pp.1080~1084 (2013)