댓잎 추출물이 구강미생물에 미치는 항산화 및 항균 효과
Antioxidant and antibacterial effect of bamboo leaves extract on oral bacteria
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
구강 질환은 전 세계적으로 심각한 건강 및 경제적 부담을 야기하여 사람들의 삶의 질을 크게 저하시킨다. 대표 구강질환인 치아우식증은 S. mutans에 의해 발생한다. 또한, 구강 병원성 미생물에는 면역 반응이 일어나면서 다양한 구강 질환을 유발할 수 있는 지질다당류(lipopolysaccharide, LPS)가 함유되어 있다. 본 연구의 목적은 구강 질환을 조절하기 위해서 대나무 잎 추출물(BLE)의 항산화 및 항균 효과를 조사하는 것이다. THP-1, oral fibroblasts, S mutans 배양액에 댓잎 추출물을 0-8% 농도별로 처리하여 실험을 진행하였다. 그 결과 단핵세포주와 구강섬유아세포에서 BLE 농도에 따른 항산화 효과를 확인하였다. 또한, BLE 농도에 따른 S. mutans의 항균 효과를 입증하였다. 따라서 BLE가 구강질환의 예방 또는 치료에 사용될 수 있음을 시사한다.
Abstract
Oral disease causes a significant health and economic burden worldwide, significantly reducing people's quality of life. Dental caries, a representative oral disease, is caused by S. mutans. Oral pathogenic microorganisms contain lipopolysaccharide (LPS), which can cause an immune response and cause various oral diseases. The purpose of this study was to investigate the antioxidant and antibacterial effects of bamboo leaf extract (BLE) to control oral diseases. THP-1, oral fibroblasts, and S mutans culture medium were treated with bamboo leaf extract at different concentrations of 0-8% to conduct the experiment.. As a result, the antioxidant effect according to the BLE concentration was confirmed in mononuclear cell lines and oral fibroblasts. In addition, the antibacterial effect of S. mutans according to the BLE concentration was demonstrated. Therefore, BLE can be used for the prevention or treatment of oral diseases.
참고문헌 (16)
- Jørn A. Aas, "Defining the Normal Bacterial Flora of the Oral Cavity", Journal of Clinical Microbiology, 43(11), pp.5721~5732 (2005), American Society for Microbiology[DOI]
- W J Loesche, "Role of Streptococcus mutans in human dental decay", Microbiological Reviews, 50(4), pp.353~380 (1986), American Society for Microbiology[DOI]
- J. M Lovegrove, "Dental plaque revisited:bacteria associated with periodontal disease", Journal of the New Zealand Society of Periodontology, (87), pp.7~21 (2004)
- S. H. Shin, "Anti-microbial Activity of Bamboo Extract Against Oral Microbes", The Journal of the Korea Contents Association, 20(12), pp.454~459 (2020)[DOI]
- Patrice James, "Chlorhexidine mouthrinse as an adjunctive treatment for gingival health", Cochrane Database of Systematic Reviews, 2021(12) (2017), Wiley[DOI]
- Susumu Okabe, "Stimulatry Effect of the Water Extract of Bamboo Grass (Fol1n Solution) on Gastric Acid Secretion in Pylorus-Ligated Rats", Japanese Journal of Pharmacology, 25(5), pp.608~609 (1975), Elsevier BV[DOI]
- Chun Hu, "Evaluation of Antioxidant and Prooxidant Activities of Bamboo <i>Phyllostachys nigra<", i> Var. <i>Henonis <, Journal of Agricultural and Food Chemistry, pp.2000, 48(8)[DOI]
- Ji Hye Yang, "Potent Anti-Inflammatory and Antiadipogenic Properties of Bamboo (<i>Sasa coreana<", i> Nakai) Leaves Extract and Its Major Constituent Flavonoids, 2017, pp.65(31), 6665~6673[DOI]
- Y ZHANG, "Isolation and purification of four flavone C-glycosides from antioxidant of bamboo leaves by macroporous resin column chromatography and preparative high-performance liquid chromatography", Food Chemistry, 107(3), pp.1326~1336 (2007), Elsevier BV[DOI]
- 정기옥, "대나무추출액의 구강미생물에 대한 항균효과", 한국콘텐츠학회 논문지, 20(12), pp.454~459 (2020), 한국콘텐츠학회[DOI]
- James J. Crall, "A Life Course Health Development Perspective on Oral Health", Handbook of Life Course Health Development, pp.299~320 (2017), Springer International Publishing[DOI]
- K. M. Kopydlowski, "Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo", The Journal of Immunology, 163(3), pp.1537~1544 (1999)
- Ok-Jin Park, "Lipopolysaccharide of Aggregatibacter actinomycetemcomitans induces the expression of chemokines MCP-1, MIP-1α, and IP-10 via similar but distinct signaling pathways in murine macrophages", Immunobiology, 220(9), pp.1067~1074 (2015), Elsevier BV[DOI]
- Zewen Liu, "Role of ROS and Nutritional Antioxidants in Human Diseases", Frontiers in Physiology, 9, pp.477~ (2018), Frontiers Media SA[DOI]
- Yoshiaki Miyake, "Isolation and extraction of antimicrobial substances against oral bacteria from lemon peel", Journal of Food Science and Technology, 48(5), pp.635~639 (2011), Springer Science and Business Media LLC[DOI]
- 채규창, "인진쑥의 구강세균에 대한 항균작용", Journal of Oral Medicine and Pain, 34(2), pp.169~177 (2009), 대한안면통증∙구강내과학회