Characterization of Peripapillary Atrophy Using Spectral Domain Optical Coherence Tomography
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Purpose: To characterize the features of peripapillary atrophy (PPA), as imaged by spectral-domain optical coherence tomography (SD-OCT). Methods: SD-OCT imaging of the optic disc was performed on healthy eyes, eyes suspected of having glaucoma,and eyes diagnosed with glaucoma. From the peripheral β-zone, the retinal nerve fiber layer (RNFL), the junction of the inner and outer segments (IS/OS) of the photoreceptor layer, and the Bruch’s membrane/retinal pigment epithelium complex layer (BRL) were visualized. Results: Nineteen consecutive eyes of 10 subjects were imaged. The RNFL was observed in the PPA β-zone of all eyes, and no eye showed an IS/OS complex in the β-zone. The BRL was absent in the β-zone of two eyes. The BRL was incomplete or showed posterior bowing in the β-zone of five eyes. Conclusions: The common findings in the PPA β-zone were that the RNFL was present, but the photoreceptor layer was absent. Presence of the BRL was variable in the β-zone areas.
Abstract
Purpose: To characterize the features of peripapillary atrophy (PPA), as imaged by spectral-domain optical coherence tomography (SD-OCT). Methods: SD-OCT imaging of the optic disc was performed on healthy eyes, eyes suspected of having glaucoma,and eyes diagnosed with glaucoma. From the peripheral β-zone, the retinal nerve fiber layer (RNFL), the junction of the inner and outer segments (IS/OS) of the photoreceptor layer, and the Bruch’s membrane/retinal pigment epithelium complex layer (BRL) were visualized. Results: Nineteen consecutive eyes of 10 subjects were imaged. The RNFL was observed in the PPA β-zone of all eyes, and no eye showed an IS/OS complex in the β-zone. The BRL was absent in the β-zone of two eyes. The BRL was incomplete or showed posterior bowing in the β-zone of five eyes. Conclusions: The common findings in the PPA β-zone were that the RNFL was present, but the photoreceptor layer was absent. Presence of the BRL was variable in the β-zone areas.
참고문헌 (17)
- Sommer A, "Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss", Arch Ophthalmol, 109, pp.77~83 (1991)
- Quigley HA, "An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage", Ophthalmology, 99, pp.19~28 (1992)
- Schuman JS, "Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography", Ophthalmology, 103, pp.1889~1898 (1996)
- Weinreb RN, "Scanning laser polarimetry to measure the nerve fiber layer of normal and glaucomatous eyes", Am J Ophthalmol, 119, pp.627~636 (1995)
- Medeiros FA, "Comparison of the GDx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus OCT optical coherence tomograph for the detection of glaucoma", Arch Ophthalmol, 122, pp.827~837 (2004)
- Leung CK, "Comparative study of retinal nerve fiber layer measurement by Stratus OCT and GDx VCC. I: correlation analysis in glaucoma", Invest Ophthalmol Vis Sci, 46, pp.3214~3220 (2005)
- Kanamori A, "Comparison of confocal scanning laser ophthalmoscopy, scanning laser polarimetry and optical coherence tomography to discriminate ocular hypertension and glaucoma at an early stage", Graefes Arch Clin Exp Ophthalmol, 244, pp.58~68 (2006)
- Hee MR, "Optical coherence tomography of the human retina", Arch Ophthalmol, 113, pp.325~332 (1995)
- Schuman JS, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography", Arch Ophthalmol, 113, pp.586~596 (1995)
- Pieroth L, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography", Ophthalmology, 106, pp.570~579 (1999)
- Jonas JB, "Parapapillary chorioretinal atrophy in normal and glaucoma eyes. II. Correlations", Invest Ophthalmol Vis Sci, 30, pp.919~926 (1989)
- Jonas JB, "Optic disc histomorphometry in normal eyes and eyes with secondary angle- closure glaucoma. II. Parapapillary region", Graefes Arch Clin Exp Ophthalmol, 230, pp.134~139 (1992)
- Jonas JB, "Glaucomatous parapapillary atrophy. Occurrence and correlations", Arch Ophthalmol, 110, pp.214~222 (1992)
- Araie M, "Factors contributing to the progression of visual field damage in eyes with normal- tension glaucoma", Ophthalmology, 101, pp.1440~1444 (1994)
- Park KH, "Correlation between peripapillary atrophy and optic nerve damage in normal- tension glaucoma", Ophthalmology, 103, pp.1899~1906 (1996)
- Menke MN, "Reproducibility of retinal thickness measurements in healthy subjects using spectralis optical coherence tomography", Am J Ophthalmol, 147, pp.467~472 (2009)
- Srinivasan VJ, "Characterization of outer retinal morphology with high-speed, ultrahighresolution optical coherence tomography", Invest Ophthalmol Vis Sci, 49, pp.1571~1579 (2008)
