The Correlation of Peripapillary and Juxtapapillary Choroidal Thickness in Healthy Subjects
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Purpose: To evaluate the correlation between the two methods of measuring the choroidal thickness around the optic nervehead (ONH). Methods: We conducted a cross-sectional study. Sixty-two eyes of 62 healthy subjects were included. Using spectral domainoptical coherence tomography, a peripapillary circle scan (diameter of 3.5 mm) and 24 radial B-scan images centered on theBruch’s membrane opening (BMO) were obtained. Peripapillary choroidal thickness (PPCT) and juxtapapillary choroidal thickness(JPCT) were measured using circle and radial B-scan images, respectively. Correlation and agreements between valuesmeasured by two methods were analyzed. Factors associated with PPCT and JPCT, and the difference between the valuesmeasured by the two methods were evaluated. Results: A total of 62 eyes of 62 healthy subjects were enrolled. Average PPCT and JPCT were 165.2 ± 50.1 and 139.7 ± 39.2μm, respectively. The linear regression analysis showed a strong correlation between both measurements (PPCT vs. JPCT, r²= 0.900, p < 0.001). PPCT and JPCT measurements showed good agreement in global and all six sectors (intraclass correlationcoefficients >0.900). Bland-Altman plot showed good agreement between the two methods with a systematic deviation of17.9 μm and a 95% limits of agreement (±1.96 standard deviation) of -9.6 to 60.5. In multivariate regression analysis, BMOarea (β = -11.87, p = 0.002) was the only factor significantly correlated with the difference between PPCT and JPCT, whichshowed a negative correlation. The difference between PPCT and JPCT measurements (PPCT - JPCT) showed a divergent tendencywith decreasing BMO area size. Conclusions: The two measures of choroidal thickness around the ONH were well correlated. However, the peripapillary choroidwas generally thicker than the juxtapapillary choroid, especially in eyes with small BMO area.
Abstract
Purpose: To evaluate the correlation between the two methods of measuring the choroidal thickness around the optic nervehead (ONH). Methods: We conducted a cross-sectional study. Sixty-two eyes of 62 healthy subjects were included. Using spectral domainoptical coherence tomography, a peripapillary circle scan (diameter of 3.5 mm) and 24 radial B-scan images centered on theBruch’s membrane opening (BMO) were obtained. Peripapillary choroidal thickness (PPCT) and juxtapapillary choroidal thickness(JPCT) were measured using circle and radial B-scan images, respectively. Correlation and agreements between valuesmeasured by two methods were analyzed. Factors associated with PPCT and JPCT, and the difference between the valuesmeasured by the two methods were evaluated. Results: A total of 62 eyes of 62 healthy subjects were enrolled. Average PPCT and JPCT were 165.2 ± 50.1 and 139.7 ± 39.2μm, respectively. The linear regression analysis showed a strong correlation between both measurements (PPCT vs. JPCT, r²= 0.900, p < 0.001). PPCT and JPCT measurements showed good agreement in global and all six sectors (intraclass correlationcoefficients >0.900). Bland-Altman plot showed good agreement between the two methods with a systematic deviation of17.9 μm and a 95% limits of agreement (±1.96 standard deviation) of -9.6 to 60.5. In multivariate regression analysis, BMOarea (β = -11.87, p = 0.002) was the only factor significantly correlated with the difference between PPCT and JPCT, whichshowed a negative correlation. The difference between PPCT and JPCT measurements (PPCT - JPCT) showed a divergent tendencywith decreasing BMO area size. Conclusions: The two measures of choroidal thickness around the ONH were well correlated. However, the peripapillary choroidwas generally thicker than the juxtapapillary choroid, especially in eyes with small BMO area.
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