Relationship between the Lamina Cribrosa, Outer Retina, and Choroidal Thickness as Assessed Using Spectral Domain Optical Coherence Tomography
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Purpose: To evaluate the characteristics and relationship between peripapillary choroidal thickness (pCT), laminacribrosa thickness (LCT), and peripapillary outer retinal layer thickness (pORT) as determined using spectraldomain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI). Methods: In total, 255 participants were included (87 healthy subjects, 87 glaucoma suspects (GS), and 81glaucoma cases). The pORT, defined as the thickness between the posterior outer plexiform layer and theretinal pigment epithelium (RPE) interface, and the pCT, between the outer margin of the RPE and the choroidal-scleral interface, were manually measured using EDI scanning of the circumpapillary retinal nerve fiberlayer (RNFL). LCT was determined by EDI scanning of the optic nerve head (ONH). Baseline characteristics,including axial length (AXL) and the SD-OCT measurements of the participants, were compared among thethree groups. The correlation between putative factors and pCT was determined using univariate and multivariatelinear regression analyses. Results: In all three groups, both pORT and pCT were thinnest in the inferior area among the four quadrants. Inthe healthy group, the mean peripapillary RNFL, pORT, and LCT were significantly greater in comparison withthose of the GS and glaucoma groups (p < 0.001, p < 0.038, and p < 0.001, respectively). The pCT demonstratedno significant differences among the three groups (p = 0.083). Only age and AXL were associatedwith pCT by multivariate analysis. Conclusions: The pCT is substantially thinner in the inferior area of the ONH. In addition, the pCT demonstratesthe strongest correlation with age and AXL, but was not associated with glaucoma or LCT.
Abstract
Purpose: To evaluate the characteristics and relationship between peripapillary choroidal thickness (pCT), laminacribrosa thickness (LCT), and peripapillary outer retinal layer thickness (pORT) as determined using spectraldomain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI). Methods: In total, 255 participants were included (87 healthy subjects, 87 glaucoma suspects (GS), and 81glaucoma cases). The pORT, defined as the thickness between the posterior outer plexiform layer and theretinal pigment epithelium (RPE) interface, and the pCT, between the outer margin of the RPE and the choroidal-scleral interface, were manually measured using EDI scanning of the circumpapillary retinal nerve fiberlayer (RNFL). LCT was determined by EDI scanning of the optic nerve head (ONH). Baseline characteristics,including axial length (AXL) and the SD-OCT measurements of the participants, were compared among thethree groups. The correlation between putative factors and pCT was determined using univariate and multivariatelinear regression analyses. Results: In all three groups, both pORT and pCT were thinnest in the inferior area among the four quadrants. Inthe healthy group, the mean peripapillary RNFL, pORT, and LCT were significantly greater in comparison withthose of the GS and glaucoma groups (p < 0.001, p < 0.038, and p < 0.001, respectively). The pCT demonstratedno significant differences among the three groups (p = 0.083). Only age and AXL were associatedwith pCT by multivariate analysis. Conclusions: The pCT is substantially thinner in the inferior area of the ONH. In addition, the pCT demonstratesthe strongest correlation with age and AXL, but was not associated with glaucoma or LCT.
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