Retinal Nerve Fiber Layer Measurement Variability with Spectral Domain Optical Coherence Tomography
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Purpose: To evaluate the effect of the scanning laser ophthalmoscope (SLO) guided re-test mode on short- and long-term measurement variability of peripapillary retinal nerve fiber layer (RNFL) thickness obtained by spectral domain-SLO optical coherence tomography (SD-SLO/OCT). Methods: Seventy five healthy eyes were scanned 3 times per day (intra-session variability) by both the SLO guided re-test mode and the independent mode of SD-SLO/OCT. Subjects were scanned 3 times by both modes at visits within a 2-week interval (inter-session variability). For testing longitudinal variability, 3 separate exams were performed over 6 months by both modes. The coefficient of variation (CV), reproducibility coefficient (RC) and intraclass correlation coefficient of RNFL thickness were compared between the two modes. Results: The intra-session RC and CV ranged from 5.4 to 12.9 microns and 1.76% to 5.72% when measured by independent mode and 5.4 to 12.5 microns and 1.75% to 5.58% by re-test mode, respectively. The inter-session RC and CV ranged from 5.8 to 13.3 microns and 1.89% to 5.78% by independent mode and 5.8 to 12.7 microns and 1.90% to 5.54% by re-test mode, respectively. Intra-session and inter-session variability measurements were not significantly different between the two modes. The longitudinal RC and CV ranged from 8.5 to 19.2 microns and 2.79% to 7.08% by independent mode and 7.5 to 14.4 microns and 2.33% to 6.22% by re-test mode, respectively. Longitudinal measurement variability was significantly lower when measured by the re-test mode compared to the independent mode (average, p = 0.011). Conclusions: The SLO guided re-test mode for RNFL thickness measurement in SD-SLO/OCT employing a tracking system improved long-term reproducibility by reducing variability induced by inconsistent scan circle placement.
Abstract
Purpose: To evaluate the effect of the scanning laser ophthalmoscope (SLO) guided re-test mode on short- and long-term measurement variability of peripapillary retinal nerve fiber layer (RNFL) thickness obtained by spectral domain-SLO optical coherence tomography (SD-SLO/OCT). Methods: Seventy five healthy eyes were scanned 3 times per day (intra-session variability) by both the SLO guided re-test mode and the independent mode of SD-SLO/OCT. Subjects were scanned 3 times by both modes at visits within a 2-week interval (inter-session variability). For testing longitudinal variability, 3 separate exams were performed over 6 months by both modes. The coefficient of variation (CV), reproducibility coefficient (RC) and intraclass correlation coefficient of RNFL thickness were compared between the two modes. Results: The intra-session RC and CV ranged from 5.4 to 12.9 microns and 1.76% to 5.72% when measured by independent mode and 5.4 to 12.5 microns and 1.75% to 5.58% by re-test mode, respectively. The inter-session RC and CV ranged from 5.8 to 13.3 microns and 1.89% to 5.78% by independent mode and 5.8 to 12.7 microns and 1.90% to 5.54% by re-test mode, respectively. Intra-session and inter-session variability measurements were not significantly different between the two modes. The longitudinal RC and CV ranged from 8.5 to 19.2 microns and 2.79% to 7.08% by independent mode and 7.5 to 14.4 microns and 2.33% to 6.22% by re-test mode, respectively. Longitudinal measurement variability was significantly lower when measured by the re-test mode compared to the independent mode (average, p = 0.011). Conclusions: The SLO guided re-test mode for RNFL thickness measurement in SD-SLO/OCT employing a tracking system improved long-term reproducibility by reducing variability induced by inconsistent scan circle placement.
참고문헌 (29)
- Burgansky-Eliash Z, "Optical coherence tomography machine learning classifiers for glaucoma detection: a preliminary study", Invest Ophthalmol Vis Sci, 46, pp.4147~4152 (2005)
- Leung CK, "Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study", Ophthalmology, 112, pp.391~400 (2005)
- Medeiros FA, "Long-term variability of GDx VCC retinal nerve fiber layer thickness measurements", J Glaucoma, 16, pp.277~281 (2007)
- Kanamori A, "Comparison of confocal scanning laser ophthalmoscopy, scanning laser polarimetry and optical coherence tomography to discriminate ocular hypertension and glaucoma at an early stage", Graefes Arch Clin Exp Ophthalmol, 244, pp.58~68 (2006)
- Manassakorn A, "Comparison of retinal nerve fiber layer thickness and optic disk algorithms with optical coherence tomography to detect glaucoma", Am J Ophthalmol, 141, pp.105~115 (2006)
- Naithani P, "Evaluation of optical coherence tomography and heidelberg retinal tomography parameters in detecting early and moderate glaucoma", Invest Ophthalmol Vis Sci, 48, pp.3138~3145 (2007)
- Parikh RS, "Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma", Ophthalmology, 114, pp.2238~2243 (2007)
- Nouri-Mahdavi K, "Detection of early glaucoma with optical coherence tomography (Stratus OCT)", J Glaucoma, 17, pp.183~188 (2008)
- Schuman JS, "Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography", Ophthalmology, 103, pp.1889~1898 (1996)
- Blumenthal EZ, "Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography", Ophthalmology, 107, pp.2278~2282 (2000)
- Paunescu LA, "Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using Stratus OCT", Invest Ophthalmol Vis Sci, 45, pp.1716~1724 (2004)
- Budenz DL, "Reproducibility of retinal nerve fiber thickness measurements using the stratus OCT in normal and glaucomatous eyes", Invest Ophthalmol Vis Sci, 46, pp.2440~2443 (2005)
- Gabriele ML, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability", Invest Ophthalmol Vis Sci, 49, pp.2315~2321 (2008)
- Cheung CY, "Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography", Ophthalmology, 115, pp.1347~1351 (2008)
- Bland JM, "Measurement error", BMJ, 312, pp.1654~ (1996)
- Lin D, "Longitudinal evaluation of optic disc measurement variability with optical coherence tomography and confocal scanning laser ophthalmoscopy", J Glaucoma, 18, pp.101~106 (2009)
- Leung CK, "Longitudinal variability of optic disc and retinal nerve fiber layer measurements", Invest Ophthalmol Vis Sci, 49, pp.4886~4892 (2008)
- Stein DM, "Effect of corneal drying on optical coherence tomography", Ophthalmology, 113, pp.985~991 (2006)
- Wu Z, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography", Ophthalmology, 114, pp.1505~1512 (2007)
- Wu Z, "Signal strength is an important determinant of accuracy of nerve fiber layer thickness measurement by optical coherence tomography", J Glaucoma, 18, pp.213~216 (2009)
- Cheung CY, "Effects of scan circle displacement in optical coherence tomography retinal nerve fibre layer thickness measurement: a RNFL modelling study", Eye (Lond), 23, pp.1436~1441 (2009)
- Leung CK, "Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study", Ophthalmology, 116, pp.1257~1263 (2009)
- Vizzeri G, "Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness", Br J Ophthalmol, 93, pp.775~781 (2009)
- Gonzalez-Garcia AO, "Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements", Am J Ophthalmol, 147, pp.1067~1074 (2009)
- Menke MN, "Reproducibility of nerve fiber layer thickness measurements using 3D fourier-domain OCT", Invest Ophthalmol Vis Sci, 49, pp.5386~5391 (2008)
- Medeiros FA, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography", Am J Ophthalmol, 139, pp.44~55 (2005)
- Artes PH, "Visual field progression in glaucoma: total versus pattern deviation analyses", Invest Ophthalmol Vis Sci, 46, pp.4600~4606 (2005)
- Wollstein G, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma", Arch Ophthalmol, 123, pp.464~470 (2005)
- Leung CK, "Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis", Invest Ophthalmol Vis Sci, 51, pp.217~222 (2010)