국소 아밀로이드증(Amyloidosis)이 동반된 안와 점막연관 림프조직형 림프종(MALT lymphoma) 1예
Primary Orbital MALT Lymphoma Associated with Localized Amyloidosis
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목적: 안와 내에 발생한 국소 아밀로이드증이 동반된 점막연관 림프조직형 림프종 증례 1예를 경험하였기에 이를 보고하고자 한다. 증례요약: 61세 남자가 내원 5개월 전부터 시작된 복시를 주소로 내원하였다. 안과 검사상 2 mm의 좌안 안구돌출과 좌측 및 상하 주시시 좌안 안구운동 제한이 관찰되었다. 자기공명영상에서 좌측 안와 하부에 조영이 잘되는 경계가 불분명한 침윤성 종괴가 확인되어좌안 절개생검을 시행하였다. 조직병리검사상 혈관과 간질에 무정형의 호산성 섬유소 물질의 침착과 소림프구 침윤이 관찰되었다. 면역 조직 화학 염색상 소림프구는 CD20 및 κ-light chain에 양성을 보였으며, 호산성 섬유소 물질은 κ-light chain에 양성을 보이고Congo red염색에서 이색성 및 녹색 복굴절이 있음을 확인하였다. 결론: 안와 내에 발생한 국소 아밀로이드증이 동반된 점막연관 림프조직형 림프종은 전세계적으로 매우 드물고 국내에서는 지금까지보고된 예가 없어 이를 보고하는 바이다.
Abstract
Purpose: To report a case of primary orbital MALT lymphoma with localized amyloidosis. Case summary: A 61-year-old male visited our clinic with diplopia, which had developed approximately 5 months earlier. Magnetic resonance imaging of the orbit showed an ill-defined well-enhanced mass in the left inferior orbit. Incisional biopsy of the orbital mass was performed. Histopathological examination revealed diffuse deposits of an amorphous, eosinophilic substance in the extracellular matrix and vessels with lymphocytes infiltration. Lymphocytes were positive for the immunohistochemical stain against the CD20 and κ-light chain antigens. The amorphous material stained positive for κ-light chain antigen, and Congo red staining showed birefringence. Conclusions: We report a rare case of primary orbital MALT lymphoma associated with localized amyloidosis.
참고문헌 (15)
- Spencer WH, "Ophthalmic Pathology", pp.2672~2698 (1985), WB Saunders
- Yoon JS, "Prognosis for patients in a Korean population with ocular adnexal lymphoproliferative lesions", Ophthal Plast Reconstr Surg, 23, pp.94~99 (2007)
- Meunier J, "Ophthalmologic and intraocular non-Hodgkin's lymphoma: a large single centre study of initial characteristics, natural history, and prognostic factors", Hematol Oncol, 22, pp.143~158 (2004)
- Knowles DM, "Amyloidosis of the orbit and adnexae", Surv Ophthalmol, 19, pp.367~384 (1975)
- Picken MM, "New insights into systemic amyloidosis: the importance of diagnosis of specific type", Curr Opin Nephrol Hypertens, 16, pp.196~203 (2007)
- Leibovitch I, "Periocular and orbital amyloidosis: clinical characteristics, management, and outcome", Ophthalmology, 113, pp.1657~1664 (2006)
- Murdoch IE, "Primary localised amyloidosis of the orbit", Br J Ophthalmol, 80, pp.1083~1086 (1996)
- Goshe JM, "Myeloma-associated orbital amyloidosis", Orbit, 29, pp.274~277 (2010)
- Dacic S, "Nodular amyloidoma and primary pulmonary lymphoma with amyloid production: a differential diagnostic problem", Mod Pathol, 13, pp.934~940 (2000)
- Caulet S, "Malignant lymphoma of mucosa associated lymphoid tissue: a new etiology of amyloidosis", Pathol Res Pract, 191, pp.1203~1207 (1995)
- Goteri G, "Localized amyloidosis and gastrointestinal lymphoma: a rare association", Histopathology, 32, pp.348~355 (1998)
- Wieker K, "Pulmonary low-grade MALT-lymphoma associated with localized pulmonary amyloidosis. A case report", Amyloid, 9, pp.190~193 (2002)
- Gupta D, "Primary bilateral mucosa-associated lymphoid tissue lymphoma of the breast with atypical ductal hyperplasia and localized amyloidosis. A case report and review of the literature", Arch Pathol Lab Med, 124, pp.1233~1236 (2000)
- Haas BD, "Orbital lymphoma, amyloid, and bone", Ophthalmology, 114, pp.1237~ (2007)
- Khaira M, "The use of radiotherapy for the treatment of localized orbital amyloidosis", Orbit, 27, pp.432~437 (2008)