싸이클로스포린 0.05% 점안액이 백내장 수술 후 발생하는 눈물분비 감소에 미치는 영향
Effects of Cyclosporine 0.05% Ophthalmic Emulsion to Improve Reduction of Tear Production after Cataract Surgery
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목적: 백내장 수술 후 발생하는 일시적인 눈물분비 감소에서 싸이클로스포린 0.05%의 임상효과를 확인하고자 한다. 대상과 방법: 49명의 환자(83안)가 수정체유화술 및 인공수정체삽입술을 시행받았으며, 이들을 세 군으로 나누어 1군은 카복시메틸셀룰로스 0.5%를 점안하였고, 2군은 싸이클로스포린 0.05%을 점안하였고, 3군은 대조군으로써 안구건조증 치료제를 점안하지 않았다. 술 전, 술 후 1일, 1주, 1달 그리고 2달에 눈물막 파괴시간(Tear Break-up Time, TBUT), 쉬르머검사 I, 각결막염색, Ocular surface diasese index (OSDI) 등의 안구건조증 관련 검사를 시행하여 비교하였다. 결과: 세 군에서 백내장수술 후 TBUT, 쉬르머검사 I, 각결막염색 소견, OSDI 점수가 악화되었으며, 싸이클로스포린 점안군에서 안구건조증의 지표들이 2달째 의미있게 호전되는 양상을 확인하였다. 카복시메틸셀룰로스 점안군에서는 백내장수술 후 주관적 소견의 악화가 거의 없었고 술 후 2달째 주관적 증상 정도가 싸이클로스포린 점안군과 비슷하게 회복되었다. 결론: 싸이클로스포린 0.05% 점안이 백내장수술 후 발생하는 일시적인 눈물분비 감소 및 각막 표면 회복에 치료적 효과가 있음을확인하였다.
Abstract
Purpose: To evaluate the efficacy of cyclosporine 0.05% in reduced tear production sign and dry eye symptoms after cataract surgery. Methods: This hospital-based prospective randomized trial included 43 patients of 83 eyes who underwent phacoemulsification. Tear break-up time, Schirmer’s test, corneal and conjunctival stain, and ocular surface disease index were performed for all patients at preoperative 1 day, and 1 day, 1 week, 1 month, and 2 months postoperatively. Group 1 received carboxymethylcellulose 0.5%, group 2 received twice-daily cyclosporine 0.05%, and group 3 did not receive any additional eye drops. Results: There was no statistically significant difference between the 3 groups in outcome measures. Two months after cataract surgery, the cyclosporine group showed improved tear break-up time, Schirmer’s test I, and corneal and conjunctival staining. Conclusions: Cyclosporine 0.05% therapy reduced dry eye signs and symptoms after cataract surgery.
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