풋귤 추출물이 생쥐의 강제 운동 부하 실험에 미치는 운동 능력 향상 효과
Immature Mandarin (Putgyul) Extract Improves Exercise Performance in a Forced-Exercise Test in Mice
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초록
본 연구에서 풋귤 열수 추출물을 6주간 강제 운동 동물모델에 투여한 결과 풋귤 열수 추출물의 전체 투여 농도 군에서(100, 200, 400 ㎎/㎏) 운동대조군 대비 유의적으로(p<0.05) LDH 감소와 대퇴근육량 증가가 나타났다. 또한, PE400 군에서는 강제 트레드밀 운동 시간 및 강제 수영 운동 시간이 모두운동대조군 대비 유의적으로(p<0.05) 나타났다. 이러한 결과를 바탕으로 풋귤은 운동 능력을 향상시키는 효능이 있는 것으로 판단된다.
Abstract
This study was to examine the effect of immature mandarin (Putgyul) extract with water (PE) on exercise endurance performance in mice subjected to forced exercise testing. We also examined the exercise-improving effects of PE on treadmill running and forced swimming tests in C57BL/6 mice. Mice were divided into five groups: non-exercise control (NC), exercise control (EC), exercise with PE 100 ㎎/㎏ (PE100), exercise with PE 200 ㎎/㎏ (PE200), exercise with PE 400 ㎎/㎏ (PE400) Groups. Mice were orally administered PE once daily for 6 weeks. After 2 weeks of PE administration, mice underwent treadmill exercise twice a week for 4 weeks and the forced swimming test on the last day. Consequently, the PE200 and PE400 groups demonstrated an increase in both treadmill exercise time and forced swimming time compared to the EC group. In addition, the PE100, PE200 and PE400 groups serum biochemical analysis showed a decrease in LDH levels, suggesting a potential reduction in fatigue. These results indicate that immature mandarin improves exercise performance through a decrease in LDH levels. This suggests the possibility of utilizing immature mandarin as a supplement for exercise.