육미지황탕 투여가 운동 지구력 향상에 미치는 영향
Effects of Yukmijihwang-tang on Maximal Exercise Performance
4
조회
0
다운로드
6
인용
0
참고문헌
키워드
초록
Yukmijihwang-tang (YM) is a well-known prescription to treat kidney inflammation on Korea. However, the effects of YM on maximal exercise performance (MEP) is not-well investigated. In this study, we aimed to evaluate the effects of YM on MEP using forced swimming test (FST) model. Mice were largely divided into three group; a non-swimming group, saline treated-swimming load test group, and YM treated-swimming load group. Swimming load test groups were re-divided into swimming control group (Control), YM fed group (YM). YM was administrated orally for 2 weeks before FST. After FST, immobility time, oxygen consumption was measured by physiological test, and serum was collected for biochemical analysis. FST induced MEP identified by increased immobility, oxygen consumption, and biochemical factors. Immobility time was significantly reduced by YM treatment compared with control group. Oxygen consumption was also significantly reduced by YM treatment. The increase on lactic acid and lactate dehydrogenase after FST was inhibited by YM treatment. In addition, consumption of energy source (free fatty acid, and triglyceride) and recovery of energy was enhanced by YM treatment after FST. In conclusion, YM inhibited the elevation of immobility time, oxygen consumption, and biochemical factors after FST. YM could be used as a beneficial agents to enhance maximal endurance exercise performance and an effective ergogenic aid in exercise training.
Abstract
Yukmijihwang-tang (YM) is a well-known prescription to treat kidney inflammation on Korea. However, the effects of YM on maximal exercise performance (MEP) is not-well investigated. In this study, we aimed to evaluate the effects of YM on MEP using forced swimming test (FST) model. Mice were largely divided into three group; a non-swimming group, saline treated-swimming load test group, and YM treated-swimming load group. Swimming load test groups were re-divided into swimming control group (Control), YM fed group (YM). YM was administrated orally for 2 weeks before FST. After FST, immobility time, oxygen consumption was measured by physiological test, and serum was collected for biochemical analysis. FST induced MEP identified by increased immobility, oxygen consumption, and biochemical factors. Immobility time was significantly reduced by YM treatment compared with control group. Oxygen consumption was also significantly reduced by YM treatment. The increase on lactic acid and lactate dehydrogenase after FST was inhibited by YM treatment. In addition, consumption of energy source (free fatty acid, and triglyceride) and recovery of energy was enhanced by YM treatment after FST. In conclusion, YM inhibited the elevation of immobility time, oxygen consumption, and biochemical factors after FST. YM could be used as a beneficial agents to enhance maximal endurance exercise performance and an effective ergogenic aid in exercise training.
참고문헌 (28)
- Bassuk, S. S., "Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease", J Appl Physiol, 99, pp.1193~1204 (2005)
- Roberts, C. K., "Effects of exercise and diet on chronic disease", J Appl Physiol, 98, pp.3~30 (2005)
- Jenkins, R. R, "Excercise, oxidative stress, and antioxidants", Int J Sport Nutr, 3, pp.356~375 (1993)
- 현경예, "20대 젊은이들에 있어 1회성 유산소운동 시 염증 표지자와 혈액변인들 간의 상관관계", 생명과학회지, 19(11), pp.1658~1665 (2009), 한국생명과학회
- Moxnes, J. F., "The kinetics of lactate production and removal during whole-body exercise", Theor Biol Med Model, 9, pp.7~ (2012)
- Mehta, R. K., "Influence of mental workload on muscle endurance, fatigue, and recovery during intermittent static work", Eur J Appl Physiol, 112, pp.2891~2902 (2012)
- Grandjean, E. P, "Fatigue", Am Ind Hyg Assoc J, 31, pp.401~411 (1970)
- Lee, C. H., "A study on drug use as a sport-deviation", J Leis Recre Stu, 21, pp.161~177 (2001)
- 사이폴 바크리, "오미자, 매실 및 당밀을 함유하는 한방스포츠음료가 실험동물의 지구력과 에너지 대사 성분에 미치는 영향", 생명과학회지, 19(2), pp.219~227 (2009), 한국생명과학회
- Yeh, T. S., "Astragalus membranaceus Improves Exercise Performance and Ameliorates Exercise-Induced Fatigue in Trained Mice", Molucules, 19, pp.2793~2807 (2014)
- 허준, "동의보감", pp.147~ (1987), 남산당
- Chen, Y., "Effects of liuwei dihuang wan and some orther TCM drugs on bone biomechanincs and serum 25 (OH)D3 content in rats", J trad chin med, 14, pp.298~302 (1994)
- Jiang, T.L, "Effect of liuwei dihuang decoction on prevention and treatment of tumor", J trad chin med, 4, pp.59~68 (1984)
- Kang, B. J., "Effects of Yukmijihwangwon in Rat models of intracerebral hemorrhage", Kor J Ori Med, 7(1), pp.125~134 (2001)
- Kang, B. J., "Effects of Yukmijihwangwon on hypoxia of neuronal cells", Kor J Ori Med, 7(1), pp.115~124 (2001)
- Leichtweis, S. B. C., "Rigorous swim training mitochondrial function in post-ischaemic rat heart", Acta Physiol Scand, 160, pp.139~148 (1997)
- Abdul, M., "Antidepressant-like effects of methanolic extract of Bacopa monniera in mice", BMC Complement Altern Med, 15, pp.337~344 (2015)
- Ishihara, K., "Chronic (-)-Hydroxycitrate Administration Spares Carbohydrate Utilization and Promotes Lipid Oxidation during Exercise in Mice", J Nutr, 130, pp.2990~2995 (2000)
- Cha, Y. S., "Exercise and", or high fat diet affect on lipid and carnitine metabolism in rats, 2000, pp.5, 37~43
- Kim, K. M., "Anti-stress and anti-fatigue effect of fermented rice bran", Phytother Res, 16, pp.700~702 (2002)
- 서상훈, "Regulation of Blood Glucose Homeostasis during Prolonged Exercise", Molecules and Cells, 23(3), pp.272~279 (2007), 한국분자세포생물학회
- Tang, W., "The anti-fatigue effect of 20(R)-ginsenoside Rg3 in mice by intranasally administration", Biol Pharm Bull, 31, pp.2024~2027 (2008)
- Bilici, M., "Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments", J Affec Disord, 64, pp.43~51 (2001)
- Abdalla, D. S., "The effect of chlorpromazine and Li2CO3 on the superoxide dismutase and glutathione peroxidase activities of rat brain, liver and erythrocytes", Biochem Mol Biol Int, 34, pp.1085~1090 (1994)
- Kimura, Y., "Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice", J Ethnopharmacol, 95, pp.447~453 (2004)
- Cairns, S.P., "Lactic acid and exercise performance: Culprit or friend?", Sports Med, 36, pp.279~291 (2006)
- Sahlin, K., "Energy supply and muscle fatigue in humans", Acta Physiol Scand, 162, pp.261~266 (1998)
- 김현희, "加味六味地黃湯의 抗疲勞와 免疫 增强 效果에 대한 연구", 동의생리병리학회지, 18(6), pp.1762~1768 (2004), 한의병리학회