PROTECTIVE Effect of Singi-Hwan on the Maximal Exercise Performance in Mice
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Singi-Hwan(SH) is a widely used prescription for treating kidney inflammation in Korea. However, the protective effect of SH on maximal exercise performance(MEP) is not well studied. Fatigue is the physiological phenomena after working and exercise to improve physical strength. The purpose of this study was to evaluate the MEP effect of SH using the FST model. To study the protective effect of SH on endurance maximal exercise performance by in vivo experiment. The mouse is largely divided into three groups; Non-swimming group, saline treatment - swimming load test group and SH processing swimming group. The swimming load test group was subdivided into the swimming control group(Control) and the Singi-Hwan supply group(SH). SH was orally administered 2 weeks before FST administration. After FST, immobility time, oxygen consumption was measured by physiological test, and serum was collected for biochemical analysis. Immobility, oxygen consumption and biochemical factors were increased FST - induced MEP. Immobility time was significantly decreased in SH treatment group compared to control group. Oxygen consumption was also significantly decreased by SH treatment. The increase of lactic acid and lactate dehydrogenase after FST was inhibited by SH treatment. Consumption of energy sources(free fatty acid and triglyceride) and energy recovery were improved by SH treatment after FST. In conclusion, SH suppressed the increase of immobility time, oxygen consumption and biochemical factors after FST. All the results suggest SH might be a potentially protective ingredient for the anti-fatigue functional food. In conclusion, SH can be used as a beneficial medium to improve maximal exercise performance and the ability to protect the body from fatigue. This study indicates that SH protects mice from physical fatigue and improves exercise performance. Therefore, it has a potential for the pharmacological effect of anti-fatigue. Our study provides new sight into the protective effects of SH on the fatigue status of mice. Additional studies are needed to find the mechanism of association between each single herb.
Abstract
Singi-Hwan(SH) is a widely used prescription for treating kidney inflammation in Korea. However, the protective effect of SH on maximal exercise performance(MEP) is not well studied. Fatigue is the physiological phenomena after working and exercise to improve physical strength. The purpose of this study was to evaluate the MEP effect of SH using the FST model. To study the protective effect of SH on endurance maximal exercise performance by in vivo experiment. The mouse is largely divided into three groups; Non-swimming group, saline treatment - swimming load test group and SH processing swimming group. The swimming load test group was subdivided into the swimming control group(Control) and the Singi-Hwan supply group(SH). SH was orally administered 2 weeks before FST administration. After FST, immobility time, oxygen consumption was measured by physiological test, and serum was collected for biochemical analysis. Immobility, oxygen consumption and biochemical factors were increased FST - induced MEP. Immobility time was significantly decreased in SH treatment group compared to control group. Oxygen consumption was also significantly decreased by SH treatment. The increase of lactic acid and lactate dehydrogenase after FST was inhibited by SH treatment. Consumption of energy sources(free fatty acid and triglyceride) and energy recovery were improved by SH treatment after FST. In conclusion, SH suppressed the increase of immobility time, oxygen consumption and biochemical factors after FST. All the results suggest SH might be a potentially protective ingredient for the anti-fatigue functional food. In conclusion, SH can be used as a beneficial medium to improve maximal exercise performance and the ability to protect the body from fatigue. This study indicates that SH protects mice from physical fatigue and improves exercise performance. Therefore, it has a potential for the pharmacological effect of anti-fatigue. Our study provides new sight into the protective effects of SH on the fatigue status of mice. Additional studies are needed to find the mechanism of association between each single herb.
참고문헌 (26)
- Bassuk SS, "Epidemiological Evi-dence for the Role of Physical Activity in Re-ducing Risk of Type 2 Diabetes and Cardio-vascular Disease", Journal of Applied Physiology, 99, pp.1193~1204 (2005)
- Roberts CK, "Effects of Exercise and Diet on Chronic Disease", Journal of Ap-plied Physiology, 98, pp.3~30 (2005)
- Jenkins RR, "Exercise, Oxidative Stress, and Antioxidants", International Journal of Sport Nutrition, 3, pp.356~375 (1993)
- 현경예, "20대 젊은이들에 있어 1회성 유산소운동 시 염증 표지자와 혈액변인들 간의 상관관계", 생명과학회지, 19(11), pp.1658~1665 (2009), 한국생명과학회
- Moxnes JF, "The Kinetics of Lactate Production and Removal during Whole-body Exercise", Theoretical Biology & Medical Modelling, 9, pp.7~19 (2012)
- Mehta RK, "Influence of Mental Workload on Muscle Endurance, Fatigue, and Recovery during Intermittent Static Work", European Journal of Applied Physiol-ogy, 112, pp.2891~2902 (2012)
- Grandjean EP, "Fatigue", American Industrial Hygiene Association Journal, 31, pp.401~411 (1970)
- Lee CH, "A Study on Drug Use as a Sport-deviation", A Journal of Leisure and Recreation Studies, 21, pp.161~177 (2001)
- 사이폴 바크리, "오미자, 매실 및 당밀을 함유하는 한방스포츠음료가 실험동물의 지구력과 에너지 대사 성분에 미치는 영향", 생명과학회지, 19(2), pp.219~227 (2009), 한국생명과학회
- Yeh TS, "Astragalus Mem-branaceus Improves Exercise Performance and Ameliorates Exercise-induced Fatigue in Trained Mice", Molecules, 19, pp.2793~2807 (2014)
- Chen Y, "Effects of Liuwei Di-huang Wan and Some Other TCM Drugs on Bone Biomechanics and Serum 25(OH)D3 Content in Rats", Journal of Traditional Chi-nese Medicine, 14, pp.298~302 (1994)
- Jiang TL, "Effect of Liuwei Di-huang Decoction on Prevention and Treat-ment of Tumor", Journal of Traditional Chi-nese Medicine, 4, pp.59~68 (1984)
- Kang BJ, "Effects of Yukmiji-hwangwon in Rat Models of Intracerebral Hemorrhage", Korean Journal of Oriental Medicine, 7(1), pp.125~134 (2001)
- Kang BJ, "Effects of Yukmijihwangwon on Hypoxia of Neuronal Cells", Korean Journal of Oriental Medicine, 7(1), pp.115~124 (2001)
- Leichtweis SBC, "Rigorous Swim Training Mitochondrial Function in Post-is-chaemic Rat Heart", Acta Physiologica Scandinavia, 160, pp.139~148 (1997)
- Abdul M, "Antide-pressant-like Effects of Methanolic Extract of Bacopa Monniera in Mice", BMC Complemen-tary and Alternative Medicine, 15, pp.337~344 (2015)
- Ishihara K, "Chronic (-)-Hydroxycitrate Admin-istration Spares Carbohydrate Utilization and Promotes Lipid Oxidation during Exer-cise in Mice", The Journal of Nutrition, 130, pp.2990~2995 (2000)
- Cha YS, "Exercise and", or High Fat Diet Affect on Lipid and Carnitine Metabo-lism in Rats, 2000, pp.5, 37~43
- Kim KM, "Anti-stress and Anti-fatigue Effect of Fer-mented Rice Bran", Phytotherapy Research, 16, pp.700~702 (2002)
- Suh SH, "Regulation of Blood Glucose Homeostasis during Pro-longed Exercise", Molecules and Cells, 23, pp.272~279 (2007)
- Tang W, "The Anti-fatigue Effect of 20(R)-ginseno-side Rg3 in Mice by Intranasally Administra-tion", Biological & Pharmaceutical Bulletin, 31, pp.2024~2027 (2008)
- Bilici M, "Antioxidative En-zyme Activities and Lipid Peroxidation in Ma-jor Depression, Alterations by Antidepres-sant Treatments", Journal Affective Disorders, 64, pp.43~51 (2001)
- Abdalla DS, "The Effect of Chlorpromazine and Li2CO3 on the Superox-ide Dismutase and Glutathione Peroxidase Activities of Rat Brain, Liver and Erythro-cytes", Biochemistry and Molecular Biology International, 34, pp.1085~1090 (1994)
- Kimura Y, "Effects of Various Eleutherococcus Senticosus Cortex on Swim-ming Time, Natural Killer Activity and Corti-costerone Level in Forced Swimming Stressed Mice", Journal of Ethnopharmacology, 95, pp.447~453 (2004)
- Cairns SP, "Lactic Acid and Exercise Perfor-mance, Culprit or Friend?", Sports Medicine, 36, pp.279~291 (2006)
- Sahlin K, "En-ergy Supply and Muscle Fatigue in Humans", Acta Physiologica Scandinavia, 162, pp.261~266 (1998)