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상황버섯이 인간 백혈병 세포주인 HL-60 세포의 분화유도 및 증식에 미치는 영향

Effect of Phellinus linteus on Differentiation and Cell Proliferation in Human Leukemia HL-60 cells

한동민|김원신|주성민|박진모|박준호|전병훈|최은영
한의병리학회 (The Society of Pathology in Korean Medicine)|2007.10|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제21권 제5호|pp. 1170-1175

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주제분류한의학

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Abstract

We have examined the effect of water extract of Phellinus linteus, a raw material of Korean traditional herbal medicine, on the induction of HL-60 cell differentiation. The proliferation of HL-60 cell was inhibited dose-dependently by treatment with various doses of P. linteus extract. It also caused a significant change in NBT reduction (7.5 times). The expression of CD11b and CD14 was increased in the cells treated with the extract, especially in those arrested at G0/G1 stage, which suggested that some components in P. Linteus extract induced HL-60 cell differentiation to granulocytic and monocyte lineages. Moreover, the expression levels of p21WAF1/CIP and p27KIP were up-regulated during HL-60 cell differentiation induced by P. Linteus extract. These results together suggest that P. Linteus extract contains potential HL-60 cell differentiation agents.

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