오갈피나무 뿌리 50% 에탄올 추출물이항허혈에 미치는 실험적 효과
Effects of Acanthopanacis Cortex Roots 50% Ethyl Alcohol Extracts on the Cerebral Hemodynamics and Cytokine Production in Cerebral Ischemic Rats
0
조회
0
다운로드
3
인용
0
참고문헌
초록
Abstract
This experimental Study was designed to investigate the mechanism of Acanthopanacis Cortex Roots(ACR) 50% ethyl alcohol extract on the improvement of regional cerebral blood flow and cytokines production in cerebral ischemic rats. And was designed to investigate whether ACR inhibits lactate dehydrogenase(LDH) activity in neuronal cells The results were as follows; ACR significantly inhibited LDH activity in neuronal cells. These results suggest that ACR prevents the neuronal death. rCBF was significantly and stably increased by ACR(10 ㎎/㎏, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. In cytokine production of serum by drawing from femoral arterial blood at 1 hr after middle cerebral arterial occlusion, experimental group was significantly decreased IL-1β and TNF-α production, and significantly increased IL-10 production compared with control group. In cytokine production of serum by drawing from femoral arterial blood at 1 hr after reperfusion, experimental group was significantly decreased IL-1β and TNF-α production, and significantly increased IL-10 production compared with control group. According to above results, the author suggest that ACR had an anti-ischemic effect through the improvement of cerebral hemodynamics, and inhibitive effect on the brain damage by inhibited IL-1β and TNF-α production, and accelerated IL-10 production.
참고문헌 (38)
- "민병일. 최근 뇌졸중에 대한 역학적 고찰. 경희의학 7", pp.280~286 (1991)
- "C.F. The nitrous oxide method for the man", pp.476~483 (1948)
- "M. Changes in extracellular calcium activity in cerebral ischemia. J. Cereb Blood Flow Metab. 1", pp.203~209 (1981)
- "the importance of calcium", pp.269~30 277 (1982)
- "재관류 손상에서 뇌조직 아민 변동과 Free Radical과의 관련성. 大韓神經科學會誌 8", pp.2~8 (1990)
- "T.J. Polymorphonuclear leukocyteaccumulation in brain region with low blood flow during the early postischemic period. Stroke 17", obre(vich), pp.246~253 (1986)
- "G.J. Influx of leukocytes and platelets in an evolving brain infarct"
- "方劑의 體系的 構成을 위한 臨床配合本草學", pp.644~645 (1996), 永林社, 서울
- "牛黃淸心元이 중대뇌동맥 결찰로 유발된 뇌허혈에 미치는 영향", 22(1), pp.78~89 (2001)
- "흰쥐의 중대뇌동맥 결찰로 유발된 腦虛血에서 星香正氣散과 藿香正氣散이 神經細胞에 미치는 효과" (2001)
- "滋陰健脾湯加枳殼?天麻가 腦細胞 및 腦血流力學 變動에 미치는 영향", 17(1), pp.64~70 (2003)
- "天麻半夏湯이 腦血流力學에 미치는 影響", 18(1), pp.194~199 (2004)
- "로부터 생리활성 물질 검정. 한국잡초학회 7", pp.289~299 (1987)
- "가시오가피 약침이 당뇨유발 억제 및 신장보호 활성에 미치는 영향", 20(3), pp.1~14 (2003)
- "Human Monocyte의 IL-8 생산억제에 미치는 류마토이드관절염 치료제로서의 오가피의 효과", 10(1), pp.49~59 (1995)
- "오가피 추출액이 면역, 항암 및 비만에 미치는 실험적 효과", 19(2), pp.389~397 (2005)
- "오가피 50% 에탄올 추출물이 면역, 항암, 뇌혈류 및 혈압에 미치는 영향", 19(5), pp.1213~1219 (2005)
- "방사선 조사 마우스에서 오가피의 면역활성 효과", 20(3), pp.670~674 (2006)
- "오가피 에탄올 추출물이 마우스의 체중 및 혈청내 지질 함량에 미치는 효과", 20(2), pp.352~357 (2006)
- "D.W. Glutamate neurotoxicity and disease of the nervous system. J. Neuron 1", pp.623~634 (1988)
- "R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20", pp.84~91 (1989)
- Chen, "J.D. A model of focal ischemic stoke in the rat", pp.738~743 (1986)
- Trembaly, L.F, "Injurious ventilatory strategiea increase cytokines and c-fos mRNA expression in an isolated rat lung model", 99(5), pp.944~952 (1999)
- Wang, C.X, "Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat", 759(2), pp.190~196 (1997)
- Stepaniak, J.A, "A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats", 155, pp.2762~2769 (1995)
- Rivera, D.L, "Interleukin-10 attenuates experimental fetal growth restriction and demise", 12(2), pp.189~197 (1998)
- Okura, Y, "Recombinant murine interleukin-12 facilitates induction of cardiac myosin-specific type 1 helper T cells in rats", 82(10), pp.1035~1042 (1998)
- "Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis", 187(9), pp.1543~1548 (1998)
- "expression in normal and pathological conditions. Horm. Res. 42", pp.1 5~2 8 (1994)
- "Expression of transforming growth factor-beta(TGF-beta) isoforms in osteosarcomas; TGF-beta3 is related to disease progression", 80(12), pp.2230~2239 (1997)
- "some fundamental questions. Is oxidant damage relevant to Parkinson's disease traumatic injury or stroke? Acta Neurol. Scand Suppl. 126", pp.23~33 (1989)
- "오가피 Ethyl Alcohol 추출물이 뇌혈류역학 및 비만에 미치는 영향" (2006)
- "A. Mechanism of disease", pp.1670~1676 (1986)
- "J.M. Mechanisms of disease oxygen-derived free radicals in postischemic tissue injury. New Eng J. Med. 312", pp.159~163 (1985)
- "Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke", 34(3), pp.671~675 (2003)
- "Recipient intramuscular cotransfection of naked plasmid transforming growth factor beta1 and interleukin 10 ameliorates lung graft ischemia-reperfusion injury", 124(2), pp.259~269 (2002)
- "Immunohistochemical investigation of caspase-1 and effect of caspase-1 inhibitor in delayed neuronal death after transient cerebral ischemia", 893(1-2), pp.113~120 (2001)
- "Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function", 27(7), pp.1309~1318 (1999)