天麻半夏湯이 腦虛血로 인한 腦血流力學的 變動에 미치는 影響
Effect of Cheonmabanhwa-Tang on the Changes in Cerebral Hemodynamics in Cerebral Ischemia of Rats
0
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Cheonmabanhwa-Tang (CBT) has been used in the Oriental Medicine for many centuries as a therapeutic agent for dizziness due to Poong-Dam. We reported that CBT had effects on the cerebral hemodynamics〔regional cerebral blood flow (rCBF), pial arterial diameter (PAD), and mean arterial blood pressure (MABP)〕in normal and cerebral ischemic rats. Therefor we designed to determine the mechanism of action of CBT. The changes of rCBF and MABP were determinated by laser-Doppler flowmetry(LDF), and the change of PAD was determinated by video-microscopy. The results were as follows:The CBT-induced increase in rCBF was significnatly inhibited by pretreatment with indomethacin (IDN, 1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase, or methylene blue (MTB, 10 ㎍/㎏, i.p.), an inhibitor of guanylate cyclase. The CBT-induced increase in PAD was also significantly inhibited by pretreatment with IDN or MTB. The CBT-induced increase in MABP was also significantly inhibited by pretreatment with IDN or MTB. In conclusion, it is suggested that CBT causes a diverse effect on cerebral hemodynamics via mediation of cyclooxygenase and guanylate cyclase.
참고문헌 (23)
- "風의 病理的 意味糾明과 中風의 原因 및 治療에 대한 東西醫學的 比較", 16(1), pp.96~117 (1995)
- "痰飮에 관한 文獻的 考察", 5(1), pp.89~102 (1997)
- "Changes in extracellular calcium activity in cerebral ischemia", pp.203~209 (1981)
- "the importance of calcium", pp.269~277 (1982)
- "재관류 손상에서 뇌조직 아민 변동과 Free Radical과의 관련성", pp.2~8 (1990)
- "천마반하탕이 뇌혈류역학에 미치는 영향", 18(1), pp.194~199 (2004)
- "이우주의 약리학 강의 V", pp.82~ (1998), 의학문화사
- "A model of focal ischemic stoke in the rat", pp.738~17 743 (1986)
- "Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide with detailed description of the closed cranial window technique in rats", pp.34~41 (1986)
- "Detailed description of a cranial window technique for acute and chronic experimentals", pp.308~6 317 (1975)
- "생리학(제6판)", pp.110~ (1996), 의학문화사
- "Nitric oxide as a secretory product of mammalian cells", pp.3051~3064 (1992)
- "Endothelium- derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the Brain", pp.385~336 388 (1988)
- "Nitric oxiderelease accounts for the biology activity of endothelium derived relaxing factor", pp.524~327 526 (1990)
- "Endogenous nitric oxide release required for long term synatic depression in the cerebellum", pp.326~349 328 (1991)
- "Nitric oxide macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells", pp.1543~1555 (1989)
- "Methylene blue inhibits hypoxic cerebral vasodilation in awake sheep", pp.2226~2232 (1992)
- "Comparison of the effects of NG-nitro-L-arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats", pp.257~264 (1994)
- "The cyclooxygenase inhibitors indomethacin and Rofecoxib reduced regional cerebral blood flow evoked by somatosensory stimulation in rats", 227(7), pp.465~473 (2002)
- "Role of inducible nitric oxide synthase and cyclooxygenase-2 endotoxin-induced cerebral hyperemia", 29(6), pp.1209~1218 (1998)
- "Role of adenosine A receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation", 278(2) (2000)
- "Subarachnoid hemorrhage impairs cerebral blood flow response to nitric oxide but not to cyclic GMP in large cerebral arteries", (1), pp.1~9 (1997)
- "SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors", pp.~2 235 (1994)