거풍제습탕이 뇌허혈이 유발된 백서의 뇌혈류 변화에 미치는 영향
Effects of Geopungjeseub-tang(Gufengchushi-tang) on the Changes of Cerebral Blood Flow in Rats
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Abstract
Objectives: Geopungjeseub-tang(Gufengchushi-tang) has been used in oriental medicine for many centuries as a therapeutic agent for hemiplegia caused by deficiency of qi(氣虛) and damp phlegm(濕痰). This study was performed to evaluate effects of Geopungjeseub-tang extract(GJT) on hemodynamics〔regional cerebral blood flow(rCBF), pial arterial diameter(PAD), mean arterial blood pressure(MABP), heart rate(HR)〕in normal rats and in rats with cerebral ischemia by middle cerebral artery(MCA) occlusion. Also, effects of adrenergic β-receptor, cyclooxygenase on response to GJT were evaluated.Methods: Laser-doppler flowmetry(LDF) measured changes of rCBF, MABP and HR. Video microscope and width analyzer measured changes in PAD.Results: rCBF and PAD increased after treatment with GJT(10㎎/㎏, i.v.) during the period of cerebral reperfusion, and pretreatment with indomethacin raised rCBF and PAD increased after treatment with GJT during the same period as above. Pretreatment with propranolol decreased rCBF, but increased after GJT treatment, but raised PAD increased after GJT treatment during this period of reperfusion.Conclusion: GJT caused diverse responses were observed in rCBF and PAD after treatment with GJT. ACF action is mediated by adrenergic β-receptor and cyclooxygenase.Result suggest that GJT has an anti-ischemic effect through the improvement of cerebral hemodynamics and has theraputic potential for cerebral apoplexy.
참고문헌 (12)
- "？|？t？？？a", pp.509~11 (2000), 켓？싱？
- "？㎃？？？이 백서의 뇌혈류개선 및 작용기전에 미치는 효과.", 14(2), pp.233~44 (2000)
- "？[？？？㎃？？？이 뇌혈류개선 및 작용기전에 미치는 영향", 15(2), pp.325~31 (2001)
- "璃힛쟁 자침이 혈압과 뇌혈류역학에 미치는 영향", 16(4), pp.307~19 (1999)
- "Balentine JD. A model of focal ischemic stroke in the rat", pp.738~43
- "Winn HR. Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide with detailed description of the closed cranial window technique in rats. J. Cereb Blood Flow Metab. 1986", pp.34~41
- "Patterson JL. Detailed description of a cranial window technique for acute and chronic experiments. Stroke. 1975", pp.308~17
- "Krasney J. Methylene blue inhibits hypoxic cerebral vasodilation in awake sheep. J. Appl. Physiol. 1992", pp.2226~32
- "이우주의 약리학 강의(제4판).", pp.82~ (1998), 의학문화사
- "Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989", pp.84~91
- "삼소음이 백서의 국소뇌혈류량과 혈압에 미치는 영향", 23(1), pp.339~ (2002)
- "Nathan CF. Nitric oxide a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 1989", pp.1543~55