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성향정기산이 흰쥐의 MCAO에 의한 국소뇌허혈에 미치는 영향

Neuroprotective Effect of Sunghyangjungki-San on Focal Cerebral Ischemia Induced by MCAO in Rats

김연섭|김효선
한의병리학회 (The Society of Pathology in Korean Medicine)|2006.06|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제20권 제3호|pp. 596-602

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참고문헌

주제분류한의학

초록

Abstract

This study evaluated neuroprotective effect of Sunghyangjungki-San (SHS) on the focal cerebral ischemia. The rats were induced infarct in cerebral cortex and caudoputamen by using temporal occlussion of the middle cerebral artery (MCAO), then water extract of SHS was treated for MCAO rats. Neuroprotective effect was evaluated by neurological score, infarct sizes and total volume, positive neurons against Bax, Caspase-3, HSP-72, and HIF-1α in infarct area with immunohistochemistry. The results obtained were as follows: Treatment of SHS improved neurological score of MCAO rats, but there was not a statistical significance. Treatment of SHS reduced significantly infarct sizes in the brain sections of MCAO rats. Treatment of SHS reduced significantly total volume of infarct of MCAO rats. Treatment of SHS reduced significantly Bax positive neurons in penumbra of cerebral cortex of MCAO rats. Treatment of SHS reduced significantly Caspase-3 positive neurons in caudoputamen and penumbra of cerebral cortex of MCAO rats. Treatment of SHS reduced significantly HSP-72 positive neurons in penumbra of cerebral cortex of MCAO rats. Treatment of SHS reduced significantly IF-1α positive neurons in penumbra of cerebral cortex of MCAO rats.

참고문헌 (38)

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