오갈피 에탄올 추출물이 뇌혈류 및 혈압에 미치는 효과
Effects of Acanthopanax Sessiliflorus SEEM Ethyl Alcohol Extract on the Cerebral Blood Flow and Mean Arterial Blood Pressure in Normal ＆ Ischemic Rats
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Abstract
This study was designed to investigate the effects of Acanthopanax sessiliflorus SEEM (ASS) on the regional cerebral blood flow (rCBF) and mean arterial blood pressure (BP) in normal rats and ischemic rats. Experimental groups of rCBF and BP in normal and ischemic rats as follows ; ALE was injected ASS leaves 45% ethyl alcohol extract, ASE was injected ASS stems 45% ethyl alcohol extract, ARE was injected ASS roots 45% ethyl alcohol extract. The results were as follows ; In normal rats, ALE and ARE significantly increased rCBF in a dose-dependent manner, but ASE significantly decreased rCBF and MABP in a dose-dependent manner. ALE increased MABP. In ischemic rats, rCBF was significantly and stably improved by ARE (10 ㎎/㎏, i.p.) during the period of cerebral reperfusion, which was contrasted with the findings of rapid and marked increase in control group. From the above results, it was thought that all part of Acanthopanax sessiliflorus SEEM was effective for hemodynamics and especially ARE was more effective than other parts.
참고문헌 (20)
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