한국 노인의 우울증상과 인지기능 저하와의 상호 인과관계 연구
The bi-directional causal relationship between depressive symptoms and cognitive decline among Korean older adults
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초록
Objectives: This study investigated the relationship between depressive symptoms and cognitive function trajectories among older adults. This study contributes to the literature by applying a reciprocal effect model to determine the causality of the associations found. Methods: Data of 1,612 participants from the Korean Longitudinal Study of Aging (2006–2018) (aged 65 and over at wave 1 and followed up until wave 7) were selected. Using data from waves 1 (2006), 4 (201y), and 7 (2018) depressive symptoms and cognitive functioning were measured based on the Center for Epidemiologic Studies Depression 10-Item Scale and the Korean version of the Mini-Mental State Examination. Autoregressive cross-lagged model analysis was employed to estimate bi-directional relationships between depressive symptoms and cognitive function over time. Results: We identified a bi-directional relationship between depressive symptoms and cognitive decline. First, depressive symptoms and cognitive function at the prior wave had a statistically significant effect at a given wave (p<.0001). Second, higher levels of depressive symptoms (t−1) predicted lower levels of cognitive function (t: wave 1→wave 4, wave 4→wave 7, β: −.087, −.055), and higher levels of cognitive function (t−1) predicted lower levels of depressive symptoms (t: wave 1→wave 4, wave 4→wave 7, β: −.123, −.140). Conclusion: This study identifies bi-directional and reciprocal causal relationships between depressive symptoms and cognitive decline over time.
Abstract
Objectives: This study investigated the relationship between depressive symptoms and cognitive function trajectories among older adults. This study contributes to the literature by applying a reciprocal effect model to determine the causality of the associations found. Methods: Data of 1,612 participants from the Korean Longitudinal Study of Aging (2006–2018) (aged 65 and over at wave 1 and followed up until wave 7) were selected. Using data from waves 1 (2006), 4 (201y), and 7 (2018) depressive symptoms and cognitive functioning were measured based on the Center for Epidemiologic Studies Depression 10-Item Scale and the Korean version of the Mini-Mental State Examination. Autoregressive cross-lagged model analysis was employed to estimate bi-directional relationships between depressive symptoms and cognitive function over time. Results: We identified a bi-directional relationship between depressive symptoms and cognitive decline. First, depressive symptoms and cognitive function at the prior wave had a statistically significant effect at a given wave (p<.0001). Second, higher levels of depressive symptoms (t−1) predicted lower levels of cognitive function (t: wave 1→wave 4, wave 4→wave 7, β: −.087, −.055), and higher levels of cognitive function (t−1) predicted lower levels of depressive symptoms (t: wave 1→wave 4, wave 4→wave 7, β: −.123, −.140). Conclusion: This study identifies bi-directional and reciprocal causal relationships between depressive symptoms and cognitive decline over time.
참고문헌 (29)
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