지역사회 거주 노인의 인지장애에 따른 우울장애 빈도
Frequency of Depressive Disorders According to Cognitive Continuum in the Elderly Living in the Community
1
조회
0
다운로드
7
인용
0
참고문헌
초록
Objective: We investigated the frequency of depressive disorders in the elderly with normal cognition (NC), mild cognitive impairment (MCI) and dementia patients living in the community to find out the association between cognitive disorders and depressive disorders in the community dwelling elderly. Methods: 6,262 baseline study subjects from November 2010 through October 2012 were enrolled based on the Korean longitudinal study on cognitive aging and dementia which is the first nationwide multi-center population based prospective cohort study in Korea. Diagnosis of MCI, dementia, major depressive disorder (MDD), minor depressive disorder (mDD) and subsyndromal depression (SSD) was made by psychiatrists with expertise in dementia based on the appropriate diagnostic criteria. Results: 4,303 NC, 1,737 MCI, 222 dementia were enrolled. The frequency of MDD, mDD, SSD were highest in dementia and lowest in NC and showed significant difference among three groups. The odds ratio also increased significantly in MCI and dementia compared with NC showing highest odds ratio in dementia. Conclusion: Our findings propose that MCI and dementia in the community dwelling elderly were significantly associated with various types of depressive disorders showing highest association tendency in dementia.
Abstract
Objective: We investigated the frequency of depressive disorders in the elderly with normal cognition (NC), mild cognitive impairment (MCI) and dementia patients living in the community to find out the association between cognitive disorders and depressive disorders in the community dwelling elderly. Methods: 6,262 baseline study subjects from November 2010 through October 2012 were enrolled based on the Korean longitudinal study on cognitive aging and dementia which is the first nationwide multi-center population based prospective cohort study in Korea. Diagnosis of MCI, dementia, major depressive disorder (MDD), minor depressive disorder (mDD) and subsyndromal depression (SSD) was made by psychiatrists with expertise in dementia based on the appropriate diagnostic criteria. Results: 4,303 NC, 1,737 MCI, 222 dementia were enrolled. The frequency of MDD, mDD, SSD were highest in dementia and lowest in NC and showed significant difference among three groups. The odds ratio also increased significantly in MCI and dementia compared with NC showing highest odds ratio in dementia. Conclusion: Our findings propose that MCI and dementia in the community dwelling elderly were significantly associated with various types of depressive disorders showing highest association tendency in dementia.
참고문헌 (35)
- "2017 Statistics Korea future population estimate"[URL]
- Park JH, "A nationwide survey on the prevalence and risk factors of late life depression in South Korea", J Affect Disord, 138, pp.34~40 (2012)
- Park JH, "Prevalence of major depressive disorder and minor depressive disorder in an elderly Korean population : results from the Korean Longitudinal Study on Health and Aging(KLoSHA)", J Affect Disord, 125, pp.234~240 (2010)
- Djernes JK, "Prevalence and predictors of depression in populations of elderly : a review", Acta Psychiatr Scand, 113, pp.372~387 (2006)
- Luppa M, "Age-and gender-specific prevalence of depression in latest-life--systematic review and meta-analysis", J Affect Disord, 136, pp.212~221 (2012)
- Sjöberg L, "Prevalence of depression : comparisons of different depression definitions in population-based samples of older adults", J Affect Disord, 221, pp.123~131 (2017)
- Ismail Z, "Prevalence of depression in patients with mild cognitive impairment : a systematic review and meta-analysis", JAMA Psychiatry, 74, pp.58~67 (2017)
- Johansson L, "Associations between depression, depressive symptoms, and incidence of dementia in Latin America: a 10", 66 Dementia Research Group Study, 2019, pp.69, 433~441
- Mitchell PB, "Depression and the older medical patient--when and how to intervene", Maturitas, 79, pp.153~159 (2014)
- Jeong HG, "Role of severity and gender in the association between late-life depression and all-cause mortality", Int Psychogeriatr, 25, pp.677~684 (2013)
- 박준혁, "아증후군적 우울증", 생물정신의학, 18(4), pp.210~216 (2011), 대한생물정신의학회
- Finkel S, "Introduction to behavioural and psychological symptoms of dementia(BPSD)", Int J Geriatr Psychiatry, 15(Suppl 1), pp.S2~S4 (2000)
- Payne JL, "Relationship of cognitive and functional impairment to depressive features in Alzheimer’s disease and other dementias", J Neuropsychiatry Clin Neurosci, 10, pp.440~447 (1998)
- Brodaty H, "Psychosis, depression and behavioural disturbances in Sydney nursing home residents: prevalence and predictors", Int J Geriatr Psychiatry, 16, pp.504~512 (2001)
- Spalletta G, "Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease", Am J Geriatr Psychiatry, 18, pp.1026~1035 (2010)
- Lima-Silva TB, "Neuropsychiatric symptoms, caregiver burden and distress in behavioral-variant frontotemporal dementia and Alzheimer’s disease", Dement Geriatr Cogn Disord, 40, pp.268~275 (2015)
- Gallagher D, "Depression and risk of Alzheimer dementia : a longitudinal analysis to determine predictors of increased risk among older adults with depression", Am J Geriatr Psychiatry, 26, pp.819~827 (2018)
- Van der Mussele S, "Depression in mild cognitive impairment is associated with progression to Alzheimer’s disease : a longitudinal study", J Alzheimers Dis, 42, pp.1239~1250 (2014)
- Leyhe T, "A common challenge in older adults: classification, overlap, and therapy of depression and dementia", Alzheimers Dement, 13, pp.59~71 (2017)
- Lyketsos CG, "Depression in Alzheimer’s disease : overview and treatment", Biol Psychiatry, 52, pp.243~252 (2002)
- Lee JH, "Frequency of depressive syndromes in elderly individuals with no cognitive impairment, mild cognitive impairment, and Alzheimer’s disease dementia in a memory clinic setting", Dement Geriatr Cogn Disord, 42, pp.135~145 (2016)
- Ji Won Han, "Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia", PSYCHIATRY INVESTIGATION, 15(8), pp.767~774 (2018), 대한신경정신의학회[DOI]
- Lee JH, "Development of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet(CERAD-K) : clinical and neuropsychological assessment batteries", J Gerontol B Psychol Sci Soc Sci, 57, pp.P47~P53 (2002)
- Ji Yang Kim, "Standardization of the Korean Version of the Geriatric Depression Scale: Reliability, Validity, and Factor Structure", PSYCHIATRY INVESTIGATION, 5(4), pp.232~238 (2008), 대한신경정신의학회
- Nunes PV, "Neuropsychiatric Inventory in community-dwelling older adults with mild cognitive impairment and dementia", J Alzheimers Dis, 68, pp.669~678 (2019)
- Geiselmann B, "Subthreshold depression in the elderly:qualitative or quantitative distinction?", Compr Psychiatry, 41, pp.32~38 (2000)
- Kuring JK, "Prevalence of depression, anxiety and PTSD in people with dementia: a systematic review and metaanalysis", Neuropsychol Rev, 28, pp.393~416 (2018)
- Köhler CA, "Neuropsychiatric disturbances in mild cognitive impairment(MCI) : a systematic review of population-based studies", Curr Alzheimer Res, 13, pp.1066~1082 (2016)
- Tough H, "Social relationships, mental health and wellbeing in physical disability: a systematic review", BMC Public Health, 17, pp.414~ (2017)
- van Agtmaal MJM, "Association of microvascular dysfunction with latelife depression : a systematic review and meta-analysis", JAMA Psychiatry, 74, pp.729~739 (2017)
- Smith GS, "Molecular imaging of serotonin degeneration in mild cognitive impairment", Neurobiol Dis, 105, pp.33~41 (2017)
- Zurkovsky L, "Cognition as a therapeutic target in late-life depression : potential for nicotinic therapeutics", Biochem Pharmacol, 86, pp.1133~1144 (2013)
- Gandelman JA, "Nicotine and networks : potential for enhancement of mood and cognition in late-life depression", Neurosci Biobehav Rev, 84, pp.289~298 (2018)
- Kazui H, "Differences of behavioral and psychological symptoms of dementia in disease severity in four major dementias", PLoS One, 11, pp.e0161092~ (2016)
- Barca ML, "Trajectories of depressive symptoms and their relationship to the progression of dementia", J Affect Disord, 222, pp.146~152 (2017)
