정상 면역 성인에서 발생한 거대세포바이러스 위염 1예
Cytomegalovirus-associated gastritis in immunocompetent adult
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초록
거대세포바이러스 감염은 주로 면역기능이 저하된 환자에서 치명적인 기회감염으로 잘 나타나는 질환이다. 한편 면역 상태가 정상인 사람에서 발생되는 경우는 매우 드물다. 저자들은 심와부 동통과 구토를 주소로 내원한 정상면역의 27세 남자 1예를 보고한다. 상부위내시경상 위 점막 결절상과 궤양소견을 보였고, 위 점막 결절과 궤양부위 조직검사상 거대세포바이러스 봉입체의 관찰로 거대세포바이러스 위염을 진단하였다. 최근 감염과 일차 감염을 나타내는 거대세포바이러스 Ig M 항체는 양성이었다. Ganciclovir와 proton pump 억제제를 병용하여 치료하였고 증상 호전과 거대세포바이러스 seroconversion을 확인하였다. 저자들은 거대세포바이러스가 정상면역 성인에서 위 궤양을 일으킬 수 있는 경우를 경험하여 보고하는 바이다.
Abstract
Cytomegalovirus (CMV) infections are usually reported in immunocompromised patients. However, it occurs rarely in immunocompetent individuals. A case of CMV associated with stomach ulcers and mucosal nodules is reported in a immunocompetent host. A previously healthy 27-year-old man visited our hospital with a thirty-day history of epigastric pain and a nine-day history of vomiting. The demonstration of intranuclear inclusion bodies in a few gastric glandular epithelial cells contributed to the diagnosis of CMV gastritis. Treatment with a proton pump inhibitor and ganciclovir was successful to mitigate the epigastric pain and vomiting.
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