패혈증
Sepsis
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Diagnosis and treatment criteria were recently updated based on the Sepsis-3 guidelines, which recommend the sequential organ failure assessment for accurate characterization of organ dysfunction. Large randomized controlled trials have found neutral results with early goal-directed therapy. To improve outcomes, treatment bundles incorporating standards for early sepsis treatment, including antibiotic and steroid treatment, were developed. Thus, future research should address the effects of steroids and immune- modulating agents on refractory septic shock as well as the development of new coagulopathy therapies and dynamic assessment tools.
Abstract
Diagnosis and treatment criteria were recently updated based on the Sepsis-3 guidelines, which recommend the sequential organ failure assessment for accurate characterization of organ dysfunction. Large randomized controlled trials have found neutral results with early goal-directed therapy. To improve outcomes, treatment bundles incorporating standards for early sepsis treatment, including antibiotic and steroid treatment, were developed. Thus, future research should address the effects of steroids and immune- modulating agents on refractory septic shock as well as the development of new coagulopathy therapies and dynamic assessment tools.
참고문헌 (21)
- 전경만, "Characteristics, management and clinical outcomes of patients with sepsis: a multicenter cohort study in Korea", Acute and Critical Care, 34(3), pp.179~191 (2019), 대한중환자의학회[DOI]
- Singer M, "The third international consensus definitions for sepsis and septic shock (Sepsis-3)", JAMA, 315, pp.801~810 (2016)
- Bone RC, "Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP", SCCM Consensus Conference Committee. American College of Chest Physicians, Chest, pp.1992, 101[DOI]
- Levy MM, "2001 SCCM", ESICM, ATS, pp.SIS international sepsis definitions conference, Crit Care Med[DOI]
- Seymour CW, "Assessment of clinical criteria for sepsis : for the third international consensus definitions for sepsis and septic shock(Sepsis-3)", JAMA, 315, pp.762~774 (2016)
- Rivers E, "Early goal-directed therapy in the treatment of severe sepsis and septic shock", N Engl J Med, 345, pp.1368~1377 (2001)
- ARISE Investigators, "Goal-directed resuscitation for patients with early septic shock", N Engl J Med, 371, pp.1496~1506 (2014)
- Lilly CM, "The ProCESS trial--a new era of sepsis management", N Engl J Med, 370, pp.1750~1751 (2014)
- Mouncey PR, "Trial of early, goal-directed resuscitation for septic shock", N Engl J Med, 372, pp.1301~1311 (2015)
- Levy MM, "The surviving sepsis campaign bundle : 2018 update", Intensive Care Med, 44, pp.925~928 (2018)
- Vieillard-Baron A, "Hemodynamic instability in sepsis : bedside assessment by Doppler echocardiography", Am J Respir Crit Care Med, 168, pp.1270~1276 (2003)
- Benomar B, "Fluid responsiveness predicted by noninvasive bioreactancebased passive leg raise test", Intensive Care Med, 36, pp.1875~1881 (2010)
- Pottecher J, "Both passive leg raising and intravascular volume expansion improve sublingual microcirculatory perfusion in severe sepsis and septic shock patients", Intensive Care Med, 36, pp.1867~1874 (2010)
- Guérin L, "The use of ultrasound in caring for patients with sepsis", Clin Chest Med, 37, pp.299~307 (2016)
- Rhodes A, "Surviving sepsis campaign : international guidelines for management of sepsis and septic shock : 2016", Intensive Care Med, 43, pp.304~377 (2017)
- Venkatesh B, "The ADRENAL study protocol : adjunctive corticosteroid treatment in critically ill patients with septic shock", Crit Care Resusc, 15, pp.83~88 (2013)
- Annane D, "Design and conduct of the activated protein C and corticosteroids for human septic shock(APROCCHSS)trial", Ann Intensive Care, 6, pp.43~ (2016)
- Fang F, "Association of corticosteroid treatment with outcomes in adult patients with sepsis : a systematic review and meta-analysis", JAMA Intern Med, 179, pp.213~223 (2019)
- Marik PE, "Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock : a retrospective before-after study", Chest, 151, pp.1229~1238 (2017)
- Putzu A, "The effect of vitamin C on clinical outcome in critically ill patients : a systematic review with meta-analysis of randomized controlled trials", Crit Care Med, 47, pp.774~783 (2019)
- Vincent JL, "Effect of a recombinant human soluble thrombomodulin on mortality in patients with sepsis-associated coagulopathy : the SCARLET randomized clinical trial", JAMA, 321, pp.1993~2002 (2019)