본문 바로가기
KERD
논문KCI 등재

근거 중심의 패혈증 치료에 대한 최신 지견

Recent Evidences of Sepsis Treatment

2

조회

0

다운로드

3

인용

0

참고문헌

키워드

주제분류내과학

초록

Severe sepsis and septic shock are conditions with a mortality rate about 50% despite of advances of antimicrobial treatment and supportive cares. Recently, investigators are trying to establish a scientific basis for identification of high-risk patients, or a standard practice for hemodynamic optimization and adjunctive pharmacologic therapies for these patients. Several randomized, controlled trials and meta-analyses about certain therapies showed significant reduction of mortality and morbidity. This article is a clinical review of contemporary management strategies recommended with evidences for severe sepsis and septic shock.

Abstract

Severe sepsis and septic shock are conditions with a mortality rate about 50% despite of advances of antimicrobial treatment and supportive cares. Recently, investigators are trying to establish a scientific basis for identification of high-risk patients, or a standard practice for hemodynamic optimization and adjunctive pharmacologic therapies for these patients. Several randomized, controlled trials and meta-analyses about certain therapies showed significant reduction of mortality and morbidity. This article is a clinical review of contemporary management strategies recommended with evidences for severe sepsis and septic shock.

참고문헌 (32)

  1. Houck PM, "Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community- acquired pneumonia", Arch Intern Med, 164, pp.637~644 (2004)
  2. Ibrahim EH, "The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting", Chest, 118, pp.146~155 (2000)
  3. Garnacho-Montero J, "Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis", Crit Care Med, 31, pp.2742~2751 (2003)
  4. Jenkins I, "Evidence-based sepsis therapy: a hospitalist perspective", J Hosp Med, 1, pp.285~295 (2006)
  5. Nguyen HB, "Emergency Department Sepsis Education Program and Strategies to Improve Survival (ED-SEPSIS) Working Group:Severe sepsis and septic shock: review of the literature and emergency department management guidelines", Ann Emerg Med, 48, pp.28~54 (2006)
  6. Rivers E, "Early Goal-Directed Therapy Collaborative Group:Early goal-directed therapy in the treatment of severe sepsis and septic shock", N Engl J Med, 345, pp.1368~1377 (2001)
  7. Dellinger RP, "International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine:Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 200", Crit Care Med, 36, pp.296~327 (2008)
  8. The Acute Respiratory Distress Syndrome Network, "Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome", N Engl J Med, 342, pp.1301~138 (2000)
  9. Malmberg K, "Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study", Circulation, 99, pp.2626~2632 (1999)
  10. Whitcomb BW, "Impact of admission hyperglycemia on hospital mortality in various intensive care unit populations", Crit Care Med, 33, pp.2772~2777 (2005)
  11. Van den Berghe G, "Intensive insulin therapy in critically ill patients", N Engl J Med, 345, pp.1359~1367 (2001)
  12. Van den Berghe G, "Intensive insulin therapy in the medical ICU", N Engl J Med, 354, pp.449~461 (2006)
  13. Lefering R, "Steroid controversy in sepsis and septic shock: a meta-analysis", Crit Care Med, 23, pp.1294~1303 (1995)
  14. Annane D, "Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock", JAMA, 288, pp.862~871 (2002)
  15. Bollaert PE, "Reversal of late septic shock with supraphysiologic doses of hydrocortisone", Crit Care Med, 26, pp.645~650 (1998)
  16. Annane D, "Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis", BMJ, 329, pp.480~488 (2004)
  17. Sessler CN, "Management of severe sepsis and septic shock", Curr Opin Crit Care, 20, pp.354~363 (2004)
  18. Annane D, "Septic shock", Lancet, 365, pp.63~78 (2005)
  19. Sprung CL, "CORTICUS Study Group:Hydrocortisone therapy for patients with septic shock", N Engl J Med, 358, pp.111~124 (2008)
  20. O'Brien JM, "Sepsis", Am J Med, 120, pp.1012~1022 (2007)
  21. Bernard GR, "Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group: Efficacy and safety of recombinant human activated protein C for severe sepsis", N Engl J Med, 344, pp.699~709 (2001)
  22. Vincent JL, "Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment", Crit Care Med, 33, pp.2266~2277 (2005)
  23. Abraham E, "Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group:Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death", N Engl J Med, 353, pp.1332~1341 (2005)
  24. in Early stage Severe Sepsis) long-term follow-up: one-year safety and efficacy evaluation, "Crit Care Med", 2007, 1457~1463
  25. Nadel S, "Researching severe Sepsis and Organ dysfunction in children: a gLobal perspective (RESOLVE) study group: Drotrecogin alfa (activated) in children with severe sepsis: a multicenter phase III randomized controlled trial", Lancet, 369, pp.836~843 (2007)
  26. Werdan K, "Immunoglobulin in sepsis: therapeutic use of immunoglobulins", Sepsis, 3, pp.239~245 (1999)
  27. Jolles S, "Clinical use of intravenous immunoglobulin", Clin Exp Immunol, 142, pp.1~11 (2005)
  28. Pildal J, "Polyclonal immunoglobulin for treatment of bacterial sepsis: a systematic review", Clin Infect Dis, 39, pp.38~46 (2004)
  29. Turgeon AF, "Meta- analysis:intravenous immunoglobulin in critically ill adult patients with sepsis", Ann Intern Med, 146, pp.193~203 (2007)
  30. Kreymann KG, "Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock", Crit Care Med, 35, pp.2677~2685 (2007)
  31. Laupland KB, "Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-analysis", Crit Care Med, 35, pp.2686~2692 (2007)
  32. Werdan K, "Score-Based Immunoglobulin Therapy of Sepsis (SBITS) Study Group:Score- based immunglobulin G therapy of patients with sepsis: The SBITS study", Crit Care Med, 35, pp.2693~2701 (2007)

관련 논문AI추천

패혈증의 치료 동향이창률대한중환자의학회 · Acute and Critical Care2010 · 제25권 제4호Early management of adult sepsis and septic shock: Korean clinical practice guidelines박철, 강성욱, 구남수, 김도완, 김수아, 박대원, 박성훈, 박소영, 박순효, 박주현, 배대환, 백문성, 서이준, 서지영, 신태건, 우아라, 유지나, 이종민, 장유진, 장지영, 정윤태, 정인석, 조광욱, 조화진, 최용준, 하태순대한중환자의학회 · Acute and Critical Care2024 · 제39권 제4호패혈성 쇼크 환자에서 응급실 기반 조기목표지향치료의 효과(중증 패혈증 캠페인)김현, 김상철, 신태용, 신형진, 이강현, 황성오대한중환자의학회 · Acute and Critical Care2010 · 제25권 제2호패혈증이용희, 조영재대한내과학회 · 대한내과학회지2019 · 제94권 제6호Application of Sepsis-3 Criteria to Korean Patients with Critical Illnesses고윤석, 권재영, 김재열, 김태엽, 김환일, 나성원, 류호걸, 문재영, 박지숙, 서지영, 윤상원, 이상학대한중환자의학회 · Acute and Critical Care2019 · 제34권 제1호균혈증을 동반한 지역사회획득 중증패혈증환자의 예후인자: 전향 적, 관찰연구권순선, 김민자, 김상일, 김양수, 김준명, 김효열, 박대원, 백경란, 손장욱, 송영구, 엄중식, 윤영경, 정희진, 천병철, 최영화, 최준용, 최희정대한감염학회 · Infection and Chemotherapy2012 · 제44권 제3호

이 간행물의 다른 논문 (10건)