패혈증의 새 정의에 대한 논쟁
Controversies Regarding the New Definition of Sepsis
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The Third International Consensus Definitions for Sepsis and Septic Shock (SEPSIS-3) task force assessed the latest pathophysiological parameters associated with sepsis and septic shock and defined sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection. This SEPSIS-3 definition may be applied using relevant clinical and biological criteria including changes in the Sequential Organ Failure Assessment score and serum lactate levels. The new definition does not include criteria for systemic inflammatory response syndrome or the concept of ‘severe sepsis.’ The SEPSIS-3 definition aims to devise more precise descriptions of sepsis and to improve clinical care. However, there are important questions relating to the clinical application of the new definition. We review the main characteristics and limitations of previous definitions and discuss some of the potential controversies raised by the new framework.
Abstract
The Third International Consensus Definitions for Sepsis and Septic Shock (SEPSIS-3) task force assessed the latest pathophysiological parameters associated with sepsis and septic shock and defined sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection. This SEPSIS-3 definition may be applied using relevant clinical and biological criteria including changes in the Sequential Organ Failure Assessment score and serum lactate levels. The new definition does not include criteria for systemic inflammatory response syndrome or the concept of ‘severe sepsis.’ The SEPSIS-3 definition aims to devise more precise descriptions of sepsis and to improve clinical care. However, there are important questions relating to the clinical application of the new definition. We review the main characteristics and limitations of previous definitions and discuss some of the potential controversies raised by the new framework.
참고문헌 (37)
- Lagu T, "Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007", Crit Care Med, 40, pp.754~761 (2012)
- Bhattacharjee P, "Identifying patients with sepsis on the hospital wards", Chest, 151, pp.898~907 (2017)
- Singer M, "The third international consensus definitions for sepsis and septic shock (Sepsis-3)", JAMA, 315, pp.801~810 (2016)
- Vincent JL, "Evolving concepts in sepsis definitions", Crit Care Nurs Clin North Am, 23, pp.29~39 (2011)
- Angus DC, "A framework for the development and interpretation of different sepsis definitions and clinical criteria", Crit Care Med, 44, pp.e113~e121 (2016)
- Bone RC, "Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP", SCCM Consensus Conference Committee. American College of Chest Physicians, Chest, pp.1992, 101[DOI]
- Vincent JL, "Dear SIRS, I'm sorry to say that I don't like you", Crit Care Med, 25, pp.372~374 (1997)
- Marshall JC, "SIRS and MODS: what is their relevance to the science and practice of intensive care?", Shock, 14, pp.586~589 (2000)
- Levy MM, "2001 SCCM", ESICM, ATS, pp.SIS international sepsis definitions conference, Crit Care Med[DOI]
- Mayr FB, "Epidemiology of severe sepsis", Virulence, 5, pp.4~11 (2014)
- Septicemia in US hospitals, "Elixhauser A", Agency for Health Care Policy and Research, ~, pp.statistical brief #122 (2006)
- Angus DC, "Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care", Crit Care Med, 29, pp.1303~1310 (2001)
- Seok Hwa Youn, "Secondary Abdominal Compartment Syndrome Recognized in Operating Room in Severely Injured Patients", Acute and Critical Care, 31(1), pp.58~62 (2016), 대한중환자의학회
- Martin GS, "The epidemiology of sepsis in the United States from 1979 through 2000", N Engl J Med, 348, pp.1546~1554 (2003)
- Vincent JL, "qSOFA does not replace SIRS in the definition of sepsis", Crit Care, 20, pp.210~ (2016)
- Kaukonen KM, "Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012", JAMA, 311, pp.1308~1316 (2014)
- Rhee C, "Regulatory mandates for sepsis care--reasons for caution", N Engl J Med, 370, pp.1673~1676 (2014)
- Vincent JL, "Sepsis in European intensive care units: results of the SOAP study", Crit Care Med, 34, pp.344~353 (2006)
- Klein Klouwenberg PM, "Classification of sepsis, severe sepsis and septic shock: the impact of minor variations in data capture and definition of SIRS criteria", Intensive Care Med, 38, pp.811~819 (2012)
- Churpek MM, "Incidence and prognostic value of the systemic inflammatory response syndrome and organ dysfunctions in ward patients", Am J Respir Crit Care Med, 192, pp.958~964 (2015)
- Kaukonen KM, "Systemic inflammatory response syndrome criteria for severe sepsis", N Engl J Med, 373, pp.881~ (2015)
- Angus DC, "Severe sepsis and septic shock", N Engl J Med, 369, pp.840~851 (2013)
- Hotchkiss RS, "Sepsis-induced immunosuppression:from cellular dysfunctions to immunotherapy", Nat Rev Immunol, 13, pp.862~874 (2013)
- Deutschman CS, "Sepsis: current dogma and new perspectives", Immunity, 40, pp.463~475 (2014)
- Singer M, "Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation", Lancet, 364, pp.545~548 (2004)
- Peach BC, "Implications of the new sepsis definition on research and practice", J Crit Care, 38, pp.259~262 (2017)
- Verdonk F, "The new sepsis definition:limitations and contribution to research and diagnosis of sepsis", Curr Opin Anaesthesiol, 30, pp.200~204 (2017)
- Marik PE, "SIRS, qSOFA and new sepsis definition", J Thorac Dis, 9, pp.943~945 (2017)
- Whittaker SA, "Severe sepsis cohorts derived from claims-based strategies appear to be biased toward a more severely ill patient population", Crit Care Med, 41, pp.945~953 (2013)
- Douw G, "Nurses' worry or concern and early recognition of deteriorating patients on general wards in acute care hospitals: a systematic review", Crit Care, 19, pp.230~ (2015)
- Cortés-Puch I, "Opening the debate on the new sepsis definition change is not necessarily progress: revision of the sepsis definition should be based on new scientific insights", Am J Respir Crit Care Med, 194, pp.16~18 (2016)
- Cheng AC, "Strategies to reduce mortality from bacterial sepsis in adults in developing countries", PLoS Med, 5, pp.e175~ (2008)
- Rello J, "Sepsis and septic shock in low-income and middle-income countries: need for a different paradigm", Int J Infect Dis, 48, pp.120~122 (2016)
- Williams JM, "Systemic inflammatory respiratory syndrome, quick sequential organ function assessment, and organ dysfunction: insights from a prospective database of ED patients with infection", Chest, 151, pp.586~596 (2017)
- Singer AJ, "Quick SOFA scores predict mortality in adult emergency department patients with and without suspected infection", Ann Emerg Med, 69, pp.475~479 (2017)
- Freund Y, "Prognostic accuracy of Sepsis-3 criteria for in-hospital mortality among patients with suspected infection presenting to the emergency department", JAMA, 317, pp.301~308 (2017)
- Sprung CL, "The new sepsis consensus definitions: the good, the bad and the ugly", Intensive Care Med, 42, pp.2024~2026 (2016)
