Hollow Poly(lactic acid) and Poly(lactic acid)/polyethylene glycol Microspheres Prepared by A Simple Fluidic Device
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Hollow poly(lactic acid) (PLA) and PLA/polyethylene glycol (PLA/PEG) microspheres using 1 wt% polyvinyl alcohol (PVA) emulsifier (continuous phase) are prepared by using tridecane (TD) as porogen in an oil-in-water emulsion using a simple fluidic device. PLA and PLA/PEG solutions in a mixture of DCM and TD were introduced into the fluidic device as a discontinuous phase. The average size of the PLA microspheres increased from 181±1.2 μm to 274±3.7 μm with increasing TD concentration from 0 to 8 wt%. PLA microspheres prepared without TD had few pores on the surface of the microspheres filled inside, while bimodal surface pores and hollow interior were observed for the PLA microspheres containing TD. As PEG was added to PLA, the size of microspheres and pores increased from 196±0.8 μm to 297±12.6 μm and from 5.0±2.7 μm (unimodal distribution) to 4.3±2.0 μm to 36.8±13.9 μm (bimodal distribution) with increasing TD concentration from 0% to 8%. The interior was changed from filled to hollow for PLA/PEG microspheres containing TD concentrations from 2% to 8%. PLA microspheres prepared with 6 wt% TD and PLA/PEG spheres with 4 wt% TD were determined as suitable candidates for fibroblast ingrowth. PLA and PLA/PEG microspheres with large void in the center of microsphere and bimodal surface pores can be effective for penetration and proliferation of host tissue.
Abstract
Hollow poly(lactic acid) (PLA) and PLA/polyethylene glycol (PLA/PEG) microspheres using 1 wt% polyvinyl alcohol (PVA) emulsifier (continuous phase) are prepared by using tridecane (TD) as porogen in an oil-in-water emulsion using a simple fluidic device. PLA and PLA/PEG solutions in a mixture of DCM and TD were introduced into the fluidic device as a discontinuous phase. The average size of the PLA microspheres increased from 181±1.2 μm to 274±3.7 μm with increasing TD concentration from 0 to 8 wt%. PLA microspheres prepared without TD had few pores on the surface of the microspheres filled inside, while bimodal surface pores and hollow interior were observed for the PLA microspheres containing TD. As PEG was added to PLA, the size of microspheres and pores increased from 196±0.8 μm to 297±12.6 μm and from 5.0±2.7 μm (unimodal distribution) to 4.3±2.0 μm to 36.8±13.9 μm (bimodal distribution) with increasing TD concentration from 0% to 8%. The interior was changed from filled to hollow for PLA/PEG microspheres containing TD concentrations from 2% to 8%. PLA microspheres prepared with 6 wt% TD and PLA/PEG spheres with 4 wt% TD were determined as suitable candidates for fibroblast ingrowth. PLA and PLA/PEG microspheres with large void in the center of microsphere and bimodal surface pores can be effective for penetration and proliferation of host tissue.
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