Synthesis of Size Controllable Silk Fibroin Microparticles and Their Stability on Different Solutions
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Silk fibroin microparticles were fabricated using a phase separation technique between silk fibroin solution and polyvinyl alcohol. We found that the concentration of polyvinyl alcohol determines the size of microparticles. The mean diameter of the silk fibroin microparticles varied from 3.48 µm to 4.05 µm. The silk fibroin microparticle size increased as a function of the concentration of PVA in aqueous silk solution. The resulting silk fibroin microparticles have narrow size distribution (i.e. monodisperse) and smooth/spherical surface. Also, we studied the effects of mouse serum, sodium phosphate buffer (PBS), and pH on the stability of the silk fibroin microparticles. Overall, we demon- strated the simple method to fabricate and to control the silk fibroin microparticles that makes our silk microparticles to be usable for a potential drug delivery carrier.
Abstract
Silk fibroin microparticles were fabricated using a phase separation technique between silk fibroin solution and polyvinyl alcohol. We found that the concentration of polyvinyl alcohol determines the size of microparticles. The mean diameter of the silk fibroin microparticles varied from 3.48 µm to 4.05 µm. The silk fibroin microparticle size increased as a function of the concentration of PVA in aqueous silk solution. The resulting silk fibroin microparticles have narrow size distribution (i.e. monodisperse) and smooth/spherical surface. Also, we studied the effects of mouse serum, sodium phosphate buffer (PBS), and pH on the stability of the silk fibroin microparticles. Overall, we demon- strated the simple method to fabricate and to control the silk fibroin microparticles that makes our silk microparticles to be usable for a potential drug delivery carrier.
참고문헌 (20)
- Sharma A, "Liposomes in drug delivery: progress and limitations", International journal of pharmaceutics, 154(2), pp.123~140 (1997)
- Noriega-Luna B, "Applications of dendrimers in drug delivery agents, diagnosis, therapy, and detection", Journal of Nanomaterials, 2014, pp.39~ (2014)
- Kumar M, "C60-fullerenes as drug delivery carriers for anticancer agents: promises and hurdles", Pharmaceutical nanotechnology, 5(3), pp.169~179 (2017)
- Yokoyama M, "Biorelated polymers and gels: controlled release and applications in biomedical engineering", pp.77~84 (1998), Biorelated polymers and gels : controlled release and applications in biomedical engineering
- Qi L, "Emerging application of quantum dots for drug delivery and therapy", Expert opinion on drug delivery, 5(3), pp.263~267 (2008)
- Zheng Z, "Silk fibroin-based nanoparticles for drug delivery", International journal of molecular sciences, 16(3), pp.4880~4903 (2015)
- Martínez-López AL, "Protein-based nanoparticles for drug delivery purposes", International Journal of Pharmaceutics, 581, pp.119289~ (2020)
- Zheng Z, "Fabrication of silk fibroin nanoparticles for controlled drug delivery", Journal of Nanoparticle Research, 14(4), pp.1~10 (2012)
- Montalbán MG, "Production of curcumin-loaded silk fibroin nanoparticles for cancer therapy", Nanomaterials, 8(2), pp.126~ (2018)
- Liu Q, "Preparation of silk fibroin carriers for controlled release", Microscopy Research and Technique, 80(3)), pp.312~320 (2017)
- Kundu J, "Silk fibroin nanoparticles for cellular uptake and control release", International journal of pharmaceutics, 388(1-2), pp.242~250 (2010)
- Cheerarot O, "Biodegradable silk fibroin", chitosan blend microparticles prepared by emulsification-diffusion method, 2015, pp.15(2), 67~74
- Wang X, "Silk nanospheres and microspheres from silk", pva blend films for drug delivery, 2010, pp.31(6), 1025~1035
- Shetty G, "Preparation and characterization of silk fibroin-polyvinyl alcohol (PVA) blend films for food packaging materials", Materials Today: Proceedings, 55, pp.194~200 (2022)
- Din Wani SU, "Silk fibroin based drug delivery applications: promises and challenges", Current Drug Targets, 19(10), pp.1177~1190 (2018)
- Lin L, "The rough inhalable ciprofloxacin hydrochloride microparticles based on silk fibroin for non-cystic fibrosis bronchiectasis therapy with good biocompatibility", International Journal of Pharmaceutics, 607, pp.120974~ (2021)
- Rockwood DN, "Materials fabrication from Bombyx mori silk fibroin", Nature protocols, 6(10), pp.1612~1631 (2011)
- Cooper DL, "Effect of formulation variables on preparation of celecoxib loaded polylactide-co-glycolide nanoparticles", PLoS One, 9(12), pp.113558~ (2014)
- Katas H, "Bovine serum albumin-loaded chitosan", dextran nanoparticles: preparation and evaluation of ex vivo colloidal stability in serum, 2013, pp.2013, 34~
- Moore TL, "Nanoparticle colloidal stability in cell culture media and impact on cellular interactions", Chemical Society Reviews, 44(17), pp.6287~6305 (2015)