알레르기 및 염증성 질환에서 호산구양이온단백과 고감도 C-반응성단백의 의의
Significance of Serum Eosinophil Cationic Protein and High-Sensitivity C-reactive Protein Levels in Patients with Allergic and Non-Allergic Inflammatory Diseases
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
배경: 본 연구는 소아 알레르기질환과 비알레르기성 염증 질환에서 혈청호산구양이온단백(eosinophil cationic protein, ECP)과 고감도C-반응단백(high sensitivity C-reactive protein, hs-CRP) 농도의 의의를 평가하고 혈청 ECP와 염증지표들 사이의 상관관계에 대해서 분석하였다. 방법: 알레르기질환의 소아 환아 146명과 비알레르기염증 환아 76명, 대조군 소아 25명을 대상으로 하였다. 혈청 ECP와 hs-CRP, 혈청 총 IgE와 특이항원 IgE 농도를 측정하였다. 결과: 알레르기 환자군에서 혈청 ECP 농도(77.5±88.2 £g/L)는 비알레르기 염증성 환자군(42.2±58.8 £g/L)과 대조군(12.7±4.2£g/L)보다 높았다(P<0.001, 각각). 비알레르기염증성 환자군의 혈청 ECP 농도 역시 대조군보다 높았다(42.2±58.8 vs. 12.7±4.2 £g/L, P<0.001). 알레르기 환자에서 hs-CRP 농도는 대조군에 비해 유의하게 증가하였다(0.4±0.9 vs. 0.1±0.2 mg/dL, P<0.05). 알레르기환자에서 혈청 ECP와 hs-CRP 농도 사이에는 유의한 상관관계가 관찰되지 않았다(r = 0.09, P >0.05). 결론: 혈청 ECP와 hs-CRP 농도 측정은 알레르기질환의 임상적 평가와 경과 관찰 시 도움이 될 것으로 기대된다. 혈청 ECP와 hs-CRP 농도의 상관관계가 없는 것으로 보아 알레르기 질환에서 혈청 ECP 농도의 상승이 반드시 전신성 염증의 정도를 반영하지는않는 것으로 생각된다.
Abstract
Background: This study was conducted to evaluate the significance of serum eosinophil cationic protein (ECP) and high-sensitivity C-reactive protein (hs-CRP) levels in children with allergic diseases and non-allergic inflammatory diseases, and to assess the relationships between serum ECP levels and inflammatory parameters. Methods: In this study, we included 146 children with allergic diseases, 76 children with non-allergic inflammatory diseases, and 25 control subjects. Serum concentrations of ECP, hs-CRP, total IgE, and allergen-specific IgE were measured. Results: Serum ECP levels (77.5±88.2 μg/L) of patients with allergic diseases were significantly higher than those of the patients with non-allergic inflammatory diseases (42.2±58.8 μg/L) and control subjects (12.7±4.2 μg/L) (P <0.001, respectively). The serum ECP levels in patients with non-allergic inflammatory diseases were also significantly higher than those in the controls (42.2±58.8 vs. 12.7±4.2 μg/L; P <0.001). The hs-CRP levels were significantly higher in patients with allergic diseases than in the controls (0.4±0.9 vs. 0.1±0.2 mg/dL; P <0.05). No significant relationship was observed between serum ECP and hs-CRP levels in the allergic patients (r=0.09, P >0.05). Conclusions: Measurement of serum ECP and hs-CRP concentrations can be helpful in the clinical evaluation and monitoring of patients with allergic diseases. No significant correlation was observed between serum ECP and hs-CRP levels in allergic patients, thereby suggesting that elevated levels of ECP do not necessarily reflect the degree of systemic inflammation in allergic diseases.
참고문헌 (30)
- Gleich GJ, "The eosinophilic leukocyte: structureand function", Adv Immunol, 39, pp.177~253 (1986)
- Hogan SP, "Eosinophils: biological properties and role in health and disease", Clin Exp Allergy, 38, pp.709~750 (2008)
- Venge P, "Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease", Clin Exp Allergy, 29, pp.1172~1186 (1999)
- Koh GC, "Saliva and serum eosinophil cationic protein in asthmatic children and adolescents with and without allergic sensitization", J Asthma, 47, pp.61~65 (2010)
- Koh GC, "Eosinophil cationic protein: is it useful in asthma? A systematic review", Respir Med, 101, pp.696~705 (2007)
- Wolthers OD, "Eosinophil granule proteins in the assessment of airway inflammation in pediatric bronchial asthma", Pediatr Allergy Immunol, 14, pp.248~254 (2003)
- Fujita M, "C-reactive protein levels in the serum of asthmatic patients", Ann Allergy Asthma Immunol, 99, pp.48~53 (2007)
- Olafsdottir IS, "C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study", Thorax, 60, pp.451~454 (2005)
- Zietkowski Z, "High-sensitivity C-reactive protein in the exhaled breath condensate and serum in stable and unstable asthma", Respir Med, 103, pp.379~385 (2009)
- Tolan RW Jr, "Fever of unknown origin: a diagnostic approach to this vexing problem", Clin Pediatr (Phila), 49, pp.207~213 (2010)
- Fitch PS, "Serum eosinophil cationic protein (ECP): reference values in healthy nonatopic children", Allergy, 54, pp.1199~1203 (1999)
- Nye L, "A detailed investigation of circulating IgE levels in a normal population", Clin Allergy, 5, pp.13~24 (1975)
- Pastorello EA, "Studies on the relationship between the level of specific IgE antibodies and the clinical expression of allergy: I. Definition of levels distinguishing patients with symptomatic from patients with asymptomatic allergy to common aeroallergens", J Allergy Clin Immunol, 96, pp.580~587 (1995)
- Silva AC, "Faecal and serum levels of eosinophil cationic protein in a healthy paediatric population", Scand J Clin Lab Invest, 67, pp.757~766 (2007)
- Lönnkvist K, "Eosinophil markers in blood, serum, and urine for monitoring the clinical course in childhood asthma: impact of budesonide treatment and withdrawal", J Allergy Clin Immunol, 107, pp.812~817 (2001)
- Prehn A, "The relationship of serum-eosinophil cationic protein and eosinophil count to disease activity in children with bronchial asthma", Pediatr Allergy Immunol, 9, pp.197~203 (1998)
- Nielsen LP, "Eosinophil markers in seasonal allergic rhinitis. Intranasal fluticasone propionate inhibits local and systemic increases during the pollen season", Allergy, 53, pp.778~785 (1998)
- Lorenzo GD, "Pellitteri ME, et al. Blood eosinophils and serum eosinophil cationic protein in patients with acute and chronic urticaria", Mediators Inflamm, 5, pp.113~115 (1996)
- Murat-Susić S, "Serum eosinophil cationic protein in children with atopic dermatitis", Int J Dermatol, 45, pp.1156~1160 (2006)
- Zietkowski Z, "Changes in high-sensitivity C-reactive protein in serum and exhaled breath condensate after intensive exercise in patients with allergic asthma", Int Arch Allergy Immunol, 153, pp.75~85 (2010)
- Sahoo RC, "A study of high-sensitivity C-reactive protein in bronchial asthma", Indian J Chest Dis Allied Sci, 51, pp.213~216 (2009)
- Cetinkaya F, "Serum ECP and total IgE levels in children with acute laryngotracheobronchitis", Int J Pediatr Otorhinolaryngol, 69, pp.493~496 (2005)
- Chen CJ, "The role of eosinophil cationic protein in patients with Mycoplasma pneumoniae infection", J Chin Med Assoc, 71, pp.37~39 (2008)
- Chu YT, "Changes in serum eotaxin and eosinophil cationic protein levels, and eosinophil count during treatment of childhood asthma", J Microbiol Immunol Infect, 40, pp.162~167 (2007)
- Abu-Ghazaleh RI, "Eosinophil granule proteins in peripheral blood granulocytes", J Leukoc Biol, 52, pp.611~618 (1992)
- Monteseirín J, "Neutrophils as a novel source of eosinophil cationic protein in IgE-mediated processes", J Immunol, 179, pp.2634~2641 (2007)
- Chen ST, "Correlation of immunoglobulin E, eosinophil cationic protein, and eosinophil count with the severity of childhood perennial allergic rhinitis", J Microbiol Immunol Infect, 39, pp.212~218 (2006)
- Sugai T, "Eosinophil cationic protein in peripheral blood of pediatric patients with allergic diseases", Clin Exp Allergy, 22, pp.275~281 (1992)
- Hidvégi E, "Higher serum eosinophil cationic protein levels in children with cow’s milk allergy", J Pediatr Gastroenterol Nutr, 32, pp.475~479 (2001)
- Allen KJ, "4. Food allergy in childhood", Med J Aust, 185, pp.394~400 (2006)