본문 바로가기
KERD
논문KCI 등재

소아 알레르기질환에서 감작 패턴에 따른 혈중 호산구와 총 IgE의 비교

Blood eosinophil counts as a biomarker for allergen sensitization in childhood allergic diseases in comparison with total IgE

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류소아과학

초록

.

Abstract

Purpose: Eosinophils and total immunoglobulin (IgE) have served as a histologic hallmark of allergic conditions. Many investigators have used total eosinophil count (TEC) and total IgE for evaluating allergic diseases. We examined differences in TEC and total IgE in allergic diseases and whether it differs according to sensitization. Methods: In this retrospective study, we enrolled 551 patients who visited Uijeongbu St. Mary’s Hospital from January 1, 2009 through December 31, 2012 for allergic diseases. We included patients with a diagnosis of atopic dermatitis (AD), allergic rhinitis (AR), asthma (AS), or urticaria (UC). We compared the TEC and total IgE level according to sensitization patterns. Results: There were 235 cases of AD, 179 cases of AS, 112 cases of AR, and 82 cases of UC. Regarding sensitization, 106 were not sensitized to any allergens, 206 were sensitized to inhalants, 109 were sensitized to food allergens, and 49 were sensitized to both food and inhalant allergens. TEC was significantly higher in the AD and AR group than in the UC group. TEC was significantly higher in those sensitized to both inhalant and food than those not sensitized. The total IgE levels were significantly higher in those sensitized to both inhalant and food than those not sensitized or sensitized to food. Total IgE levels were significantly higher in those sensitized to inhalant than those not sensitized or sensitized to food. Conclusion: Eosinophils appear to play differential roles in the expression of different types of allergic diseases. Total IgE level may play a significant role in sensitization.

참고문헌 (32)

  1. Breiteneder H, "Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma", Allergy, 75, pp.3039~3068 (2020)
  2. Basu MN, "Biomarkers in asthma in the context of atopic dermatitis in young children", Pediatr Allergy Immunol, 33, pp.e13823~ (2022)
  3. O’Sullivan JA, "Eosinophils and eosinophil-associated diseases : an update", J Allergy Clin Immunol, 141, pp.505~517 (2018)
  4. Robinson DS, "Eosinophil cationic protein (ECP) and eosinophil protein X (EPX) concentrations in serum and bronchial lavage fluid in asthma. Effect of prednisolone treatment", Clin Exp Allergy, 25, pp.1118~1127 (1995)
  5. Stelmach I, "The ECP", Eo count ratio in children with asthma, 2004, pp.41, 539~546
  6. Kolkhir P, "Type 2 chronic inflammatory diseases : targets, therapies and unmet needs", Nat Rev Drug Discov, 22, pp.743~767 (2023)
  7. Tu YL, "Total serum IgE in a population-based study of Asian children in Taiwan : reference value and significance in the diagnosis of allergy", PLoS One, 8, pp.e80996~ (2013)
  8. Benson VS, "Blood eosinophil counts in the general population and airways disease : a comprehensive review and meta-analysis", Eur Respir J, 59, pp.2004590~ (2022)
  9. Halken S, "Prevention of allergic disease in childhood : clinical and epidemiological aspects of primary and secondary allergy prevention", Pediatr Allergy Immunol, 15(Suppl 16), pp.4~5 (2004)
  10. Koh HS, "Relationship between serum total IgE, specific IgE, and peripheral blood eosinophil count according to specific allergic diseases", Allergy Asthma Respir Dis, 1, pp.123~128 (2013)
  11. Li Y, "The correlation of serum eosinophil cationic protein level with eosinophil count, and total IgE level in Korean adult allergic rhinitis patients", Asian Pac J Allergy Immunol, 34, pp.33~37 (2016)
  12. Small P, "Allergic rhinitis", Allergy Asthma Clin Immunol, 14(Suppl 2), pp.51~ (2018)
  13. Muraro A, "Dietary prevention of allergic diseases in infants and small children. Part II. Evaluation of methods in allergy prevention studies and sensitization markers. Definitions and diagnostic criteria of allergic diseases", Pediatr Allergy Immunol, 15, pp.196~205 (2004)
  14. Crapo RO, "Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999", Am J Respir Crit Care Med, 161, pp.309~329 (2000)
  15. Zuberbier T, "The international EAACI", GA²LEN, APAAACI guideline for the definition, classification, diagnosis, and management of urticaria, pp.Allergy, 2022[DOI]
  16. Sastre B, "Eosinophils : old players in a new game", J Investig Allergol Clin Immunol, 28, pp.289~304 (2018)
  17. Kita H, "Biology of eosinophils", Middleton’s Allergy Principles and Practice, 8, pp.265~279 (2013)
  18. Nair P, "Measuring bronchitis in airway diseases : clinical implementation and application : airway hyperresponsiveness in asthma : its measurement and clinical significance", Chest, 138(2 Suppl), pp.38S~43S (2010)
  19. Kim KW, "Serum eosinophil-derived neurotoxin(EDN)in diagnosis and evaluation of severity and bronchial hyperresponsiveness in childhood asthma", Lung, 185, pp.97~103 (2007)
  20. Zhang XY, "Full blood count parameters for the detection of asthma inflammatory phenotypes", Clin Exp Allergy, 44, pp.1137~1145 (2014)
  21. Chang KL, "Analysis of serum total IgE, specific IgE and eosinophils in children with acute and chronic urticaria", J Microbiol Immunol Infect, 46, pp.53~58 (2013)
  22. Takebuchi Y, "Acute exacerbation of hypereosinophilic syndrome complicated with dermatitis, enteritis, and myositis : a case report", Cureus, 15, pp.e34090~ (2023)
  23. Baldwa VS, "Blood histamine levels and eosinophil, basophil counts in urticaria", Ann Allergy, 34, pp.351~355 (1975)
  24. Kolkhir P, "Eosinopenia, in chronic spontaneous urticaria, is associated with high disease activity, autoimmunity, and poor response to treatment", J Allergy Clin Immunol Pract, 8, pp.318~325 (2020)
  25. Olbrich CL, "Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation", Mucosal Immunol, 13, pp.777~787 (2020)
  26. Guthier HE, "Targeting eosinophils in mouse models of asthma", Methods Mol Biol, 2506, pp.211~222 (2022)
  27. Kool M, "Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells", J Exp Med, 205, pp.869~882 (2008)
  28. Daniluk U, "Longitudinal observation of children with enhanced total serum IgE", Ann Allergy Asthma Immunol, 114, pp.404~410 (2015)
  29. Wu G, "Profiles of sensitization and comorbidity in asthma patients with markedly increased serum total IgE(>1000kU", L), 2022, pp.43, 124~132
  30. Hu Y, "Clinical relevance of eosinophils, basophils, serum total IgE level, allergen-specific IgE, and clinical features in atopic dermatitis", J Clin Lab Anal, 34, pp.e23214~ (2020)
  31. Kim EJ, "Assessment of total", specific IgE levels against 7 inhalant allergens in children aged 3 to 6 years in Seoul, Korea, 2013, pp.5, 162~169
  32. Kim JH, "The association between serum lead and total immunoglobulin E levels according to allergic sensitization", Am J Rhinol Allergy, 30, pp.e48~e52 (2016)

관련 논문AI추천

알레르기질환과 혈청 총 IgE 농도, 혈청 특이 IgE 농도, 말초혈액 총 호산구 수와의 관계고한석, 나영호, 이경석, 최선희, 한동훈대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제2호소아 알레르기 질환에서 혈청 총 IgE의 임상적 의의안지영, 최봉석대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2017 · 제5권 제4호비염 증상을 나타낸 소아에서 비즙 호산구와총 호산구수, 총 IgE 농도, 그리고집먼지진드기 특이 IgE 농도 사이의 연관성신경섭, 최성식, 한윤수대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2005 · 제15권 제1호소아 천식 및 호산구성기관지염에서 유도객담 호산구분율과 혈청 및 혈액 알레르기 지표와 연관성권정은, 김동섭, 김현아, 박배균, 안지영, 최봉석, 최재영대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2020 · 제8권 제4호유아기의 흡입 항원 감작이 알레르기 비염과 천식에 미치는 영향김경원, 김봉성, 김지현, 김효빈, 박민지, 박지수, 백은영, 백혜성, 서동인, 송근백, 신윤호, 안강모, 윤지선, 이다경, 이소연, 정성수, 조현주, 최선희, 최엄지, 홍수종대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2025 · 제13권 제3호학동전기 천식환자에서 혈청 총 IgE와 항원감작 및 기관지과민성과의 관계강임주, 윤기태, 전재성대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2009 · 제19권 제3호

이 간행물의 다른 논문 (7건)