비염 증상을 나타낸 소아에서 비즙 호산구와총 호산구수, 총 IgE 농도, 그리고집먼지진드기 특이 IgE 농도 사이의 연관성
Correlation of Appearance of Nasal Eosinophils withLevels of Total Eosinophil Counts, Total IgE, and House DustMite Specific IgE in Children with Symptoms of Rhinitis
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목 적 : 비즙 호산구 검사는 알레르기비염의 진단에 유용하고 신뢰성이 있는 검사로 알려져 있다. 그러나 비즙 호산구 검출 여부에 따른 총 호산구수, 총 IgE 농도, 집먼지진드기 특이 IgE 농도의 차이에 대해서는 거의 알려져 있지 않다. 본 연구에서는 비즙 호산구가 검출된 환자와 검출되지 않은 환자들 간에 총 호산구수, 총 IgE 농도, 집먼지진드기 특이 IgE 농도의 차이를 알아보고자 하였다.방 법 : 비염증상을 나타낸 16세 미만의 소아 278명을 대상으로 혈중 총 호산구수, 혈청 총 IgE 농도, 집먼지진드기 특이 IgE 농도, 비즙 도말 검사상 호산구가 전혀 검출되지 않은 군과 trace군(1-5%), 양성군(5% 이상)으로 분류하여 각각에서 혈중 총 호산구수, 혈청 총 IgE 농도, 집먼지진드기 특이 IgE 농도의 평균을 비교하였다. 또한 혈중 총 호산구수, 혈청 총 IgE 농도, 집먼지진드기 특이 IgE 농도를 수치로 따라 몇 개의 군으로 구분하고 각각에서 비즙 호산구 양성률을 구하였다.결 과 : 비점막 호산구 양성률은 연령이 많을수록 높았다. 비점막 호산구가 양성인 환자들에서의 혈중 총 호산구수, 혈청 총 IgE 농도, 집먼지 특이 IgE 농도는 trace군과 음성군에 비해 유의하게 높았다. 결 론:알레르기비염 증상을 나타낸 소아 환자에서 혈중 총 호산구수, 혈청 총 IgE 농도, 그리고 집먼지진드기 특이 IgE 농도는 비즙 호산구 검출 정도와 유의한 연관성을 나타내었다.
Abstract
Purpose:Nasal cytology for eosinophils has been reported to be very useful for the diagnosis of allergic rhinitis. The purpose of this study is to describe the relationship of the appearance of nasal eosinophils with the levels of total eosinophil counts, total IgE, and house dust mite specific IgE in child patients with symptoms of rhinitis. Methods:Two hundred seventy eight children with symptoms of rhinitis less than 16 years of age were recruited and evaluated for the following variables:total eosinophil counts, total IgE concentrations, house dust mite specific IgE concentrations, and nasal cytology for eosinophils. Results:The rate of appearance of nasal eosinophils graded as positive rose as the children's age increased. The levels of total eosinophil counts, total IgE concentrations and house dust mite-specific IgE concentrations were significantly higher in children with nasal eosinophils graded as positive than those with less than 5 percent of nasal eosinophils. The rates of appearance of nasal eosinophils graded as positive below and above 250/µL of total eosinophil counts, 250 kUa/L of total IgE concentrations, and 2 kUa/L of house dust mite(D. pteronyssinus or D. farinae) specific IgE concentrations were 16 and 41 percent, 27 and 56 percent, and 13 and 68 percent, respectively Conclusion:The levels of total eosinophil counts, total IgE concentrations, and house dust mite specific IgE concentrations correlate significantly with the recovery of nasal eosinophils in children with symptoms of rhinitis.
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