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소아 아토피피부염에서 아토피성과 비아토피성의 중증도와 검사소견의 비교

Comparison of Clinical Severity and Laboratory Results between Atopic and Non-atopic Eczema in Children

전유훈|양현종|편복양|신정은
대한 소아알레르기 호흡기학회 (The Korean Academy Of Pediatric Allergy And Respiratory Disease)|2008.09|Allergy Asthma & Respiratory Disease (알레르기 천식 호흡기질환)|제18권 제3호|pp. 219-227

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참고문헌

키워드

Atopic dermatitisAtopic eczemaEosinophilEosinophil cationic proteinImmunoglobuline E
주제분류소아과학

초록

Purpose:We aim to compare clinical severity of atopic and non-atopic eczema in children and examine the relationship between total-IgE, eosinophil counts, Eosinophil, Eosinophil cationic protein (ECP) and clinical severity of atopic dermatitis (AD). Methods:A total of 271 children diagnosed with AD at the Pediatric Allergy Respiratory Center in Soonchunhyang University Hospital from October 2005 to March 2008 were enrolled for this study and divided into 2 groups: atopic and non-atopic eczema. Serum concentrations of total- and specific-IgE, eosinophil counts and ECP were measured. Allergy skin tests were also performed and the SCORAD index was used to evaluate clinical severity. Comparisons the SCORAD index and serum total-IgE, eosinophil count and ECP between the 2 groups were made. Results:Of the 271 patients, 162 (59.8%) were included in the atopic eczema group, while 109 (40.2%) were included in the non-atopic group according to the laboratory results. Serum total- IgE, eosinophil counts, ECP, the SCORAD index and the frequency of a family history of eczema were relatively higher in the atopic group. In the atopic group, serum total-IgE, eosinophil counts and ECP each had a statistically significant correlation with the SCORAD index with eosinophil counts showing the highest correlation. However, only eosinophil counts had a statistically significant correlation with the SCORAD index in the non-atopic group. Conclusion:Serum total-IgE, eosinophil counts, and ECP can be used as markers for clinical severity in patients with atopic eczema, while eosinophil counts be used as marker for clinical severity in those with non-atopic eczema.

Abstract

Purpose:We aim to compare clinical severity of atopic and non-atopic eczema in children and examine the relationship between total-IgE, eosinophil counts, Eosinophil, Eosinophil cationic protein (ECP) and clinical severity of atopic dermatitis (AD). Methods:A total of 271 children diagnosed with AD at the Pediatric Allergy Respiratory Center in Soonchunhyang University Hospital from October 2005 to March 2008 were enrolled for this study and divided into 2 groups: atopic and non-atopic eczema. Serum concentrations of total- and specific-IgE, eosinophil counts and ECP were measured. Allergy skin tests were also performed and the SCORAD index was used to evaluate clinical severity. Comparisons the SCORAD index and serum total-IgE, eosinophil count and ECP between the 2 groups were made. Results:Of the 271 patients, 162 (59.8%) were included in the atopic eczema group, while 109 (40.2%) were included in the non-atopic group according to the laboratory results. Serum total- IgE, eosinophil counts, ECP, the SCORAD index and the frequency of a family history of eczema were relatively higher in the atopic group. In the atopic group, serum total-IgE, eosinophil counts and ECP each had a statistically significant correlation with the SCORAD index with eosinophil counts showing the highest correlation. However, only eosinophil counts had a statistically significant correlation with the SCORAD index in the non-atopic group. Conclusion:Serum total-IgE, eosinophil counts, and ECP can be used as markers for clinical severity in patients with atopic eczema, while eosinophil counts be used as marker for clinical severity in those with non-atopic eczema.

참고문헌 (37)

  1. Pediatr Allergy Respir Dis (Korea), "Pediatric allergy, respiratology, immunology", pp.145~173 (2005), Seoul : Koonja Press
  2. 공도연, "소아 아토피피부염의 치료에 Lactobacillus casei 경구 투여의 효과에 대한 연구", 대한소아알레르기및호흡기학회지, 17(1), pp.27~37 (2007), 대한 소아알레르기 호흡기학회
  3. 앙현종, 편복양, 홍용희, 전유훈, "반복적인 영아 천명에서 지속성 천명으로의 진행에관여하는 위험 인자", 대한소아알레르기및호흡기학회지, 17(1), pp.17~26 (2007), 대한 소아알레르기 호흡기학회
  4. 전유훈, 양현종, 편복양, "영아기 아토피피부염 환자의 천명발생 위험인자에 대한 연구", 대한소아알레르기및호흡기학회지, 17(2), pp.109~116 (2007), 대한 소아알레르기 호흡기학회
  5. Pediatr Allergy Respir Dis(Korea), "Guideline of atopic dermatitis in Korean children", pp.3~4 (2008), Seoul : Kwangmun Press
  6. Lee HS, "Changes of the prevalence and allergens of atopic dermatitis in children: in between the year of 1992 and 2002", Pedaitr Allergy Respir Dis, 12, pp.263~271 (2002)
  7. Sung HC, "A study on the relationship of allergy-related laboratory findings with the clinical severity of atopic dermatitis", Korean J Dermatol, 44, pp.1051~1057 (2006)
  8. Kim MN, "Eosinophil counts in peripheral blood, serum total IgE, eosinophil cationic protein, IL-4 and soluble E-selectin in atopic dermatitis", Korean J Dermatol, 40, pp.1367~1373 (2002)
  9. Gugesell C, "Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores", Br J Dermatol, 147, pp.914~919 (2002)
  10. Wuthrich B, "Atopic dermatitis flare provoked by inhalant allergens", Dermatologica, 178, pp.51~53 (1989)
  11. Bardana EJ Jr, "Immunoglobulin E and non-IgE mediated reactions in the pathogenesis of atopic eczema", dermatitis syndrome(AEDS), 2004, pp.59, S25~S29
  12. Novembre E, "Natural history of "intrinsic" atopic dermatitis", Allergy, 56, pp.452~453 (2001)
  13. Hanifin JM, "Diagnostic features of atopic dermatitis", Acta Derm Venereol, 92, pp.44~47 (1980)
  14. Kunz B, "Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on atopic dermatitis", Dermatology, 195, pp.10~19 (1997)
  15. Adkinson NF, "Middleton's Allergy Principles & practice", pp.1088~1089 (2003), Philadelphia : Mosby
  16. Tan BB, "Double-blind controlled trial of effect of housedust-mite allergen avoidance on atopic dermatitis", Lancet, 347, pp.15~18 (1996)
  17. Schafer T, "Association between severity of atopic eczema and degree of sensitization to aeroallergens in schoolchildren", J Allergy Clin Immunol, 104, pp.1280~1284 (1999)
  18. Kang K, "Atopic dermatitis. An evaluation of clinical and laboratory findings", Int J Dermatol, 26, pp.27~32 (1987)
  19. Stone SP, "IgE levels in atopic dermatitis", Arch Dermatol, 108, pp.806~811 (1973)
  20. Clendenning WE, "Serum IgE studies in atopic dermatitis", J Invest Dermatol, 61, pp.233~236 (1973)
  21. Kang DG, "study of peripheral blood eosinophil and serum IgE level in patients with atopic dermatitis", Korean J Dermatol, 30, pp.51~56 (1992)
  22. Sampson HA, "Role of immediate hypersensitivity in the pathogenesis of atopic dermatitis", Allergy, 44(1), pp.52~58 (1989)
  23. Noh GW, "Blood eosinophils and serum IgE as predictors for prognosis of interferon- gamma therapy in atopic dermatitis", Allergy, 53, pp.1202~1207 (1998)
  24. Kaliner M, "Rhinitis and asthma", JAMA, 268, pp.2807~2829 (1992)
  25. Juhlin L, "Immunoglobulin E in dermatoses: levels in atopic dermatitis and urticaria", Arch Dermatol, 100, pp.12~16 (1969)
  26. Lee JH, "A study on the relationship of the severity of atopic dermatitis, serum IgE and IFN-gamma", Korean J Dermatol, 39, pp.1067~1071 (2001)
  27. Gunnar S, "Immunoglobulin E in "healed" atopic dermatitis and after treatment with corticosteroids and azathioprine", Br J Dermatol, 82, pp.10~13 (1970)
  28. Weller PF, "Eosinophilia", J Allergy Clin Immunol, 73, pp.1~10 (1984)
  29. Kagi MK, "Correlation of eosinophils, eosinophil cationic protein and soluble interleukin-2 receptor with the clinical activity of atopic dermatitis", Dermatology, 185, pp.88~92 (1992)
  30. Uehara M, "Blood eosinophilia in atopic dermatitis", Clin Exp Dermatol, 15, pp.264~266 (1990)
  31. Schmid-Grendelmeier P, "Epidemiology, clinical features and immunology of the "intrinsic" (non-IgE-mediated) type of atopic dermatitis (constitutional dermatitis)", Allergy, 56, pp.841~849 (2001)
  32. Lee JS, "The classification between IgE and non-IgE mediated atopic dermatitis in Korean children", Pediatr Allergy Respir Dis, 15, pp.352~358 (2005)
  33. Simon D, "Eosinophils and atopic dermatitis", Allergy, 59, pp.561~570 (2004)
  34. Venge P, "Eosinophil and neutrophil granulocytes", Allergy, 48(17), pp.39~47 (1993)
  35. Ackerman SJ, "Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin", J Immunol, pp.2977~2982 (1983)
  36. Czech W, "Serum eosinophil cationic protein is a sensitive measure for disease activity in atopic dermatitis", Br J Dermatol, 126, pp.351~355 (1992)
  37. Gebhardt M, "Monitoring of serologic immune parameters in inflammatory skin diseases", Allergy, 52, pp.1087~1094 (1997)

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SCORing atopic dermatitis index로 평가한 아토피피부염의 중증도와 혈액 검사와의 연관성김성원, 박근화, 박종하, 성명순, 황윤하대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제1호중증 소아 아토피피부염 환자의 임상적 특징강정우, 김성원, 이은영, 정진우대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2009 · 제19권 제4호소아에서 IgE 매개성과 비 IgE 매개성 아토피피부염의 특징김형수, 서선복, 정지인, 정진아대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제4호IgE 매개성, 비 IgE 매개성 소아 아토피피부염 환아의분류에 관한 연구김자형, 김태홍, 이주석, 정진아, 조경래대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2005 · 제15권 제4호2세 이하 영유아 중증 아토피피부염에서의 항원 감작김병주, 나혜연, 송영화, 유진호, 이소연, 홍수종대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2009 · 제19권 제2호아토피피부염 환자에서 중증도 변화에 따른 SCORAD index와 혈청 총 IgE 및 호산구 수의 상관관계강민서, 곽재영, 김민희, 최인화대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2018 · 제31권 제1호

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