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흰쥐 내측 전정핵 뉴론에서 Norepinephrine의 포타슘 전류 억제 효과

Inhibitory Effects of Norepinephrine on the Potassium Current of Rat Medial Vestibular Nuclear Neurons

조기현|김병채|박종성|황매|장명주|정한성|허해룡
대한신경과학회 (Korean Neurological Association)|2005.06|대한신경과학회지 (Journal of the Korean Neurological Association)|제23권 제3호|pp. 363-365

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참고문헌

주제분류신경과학

초록

Abstract

Background: This study aimed to explore the effects of norepinephrine on the potassium currents of rat medial vestibular nuclear neurons by using the whole-cell patch clamp technique. Methods: Sprague-Dawley rats aged 14 to 16 days were anesthetized with ether and decapitated. After enzymatic digestion, the portion of the medial vestibular nucleus neurons were obtained by micropunching. The dissociated neurons were transferred into a recording chamber mounted on an inverted microscope and potassium currents were recorded by standard patch-clamp techniques under voltage-clamp modes. Results: Norepinephrine inhibited the whole potassium currents of the medial vestibular nuclear neurons. Outward potassium currents were more suppressed in 4 mM 4-aminopyridine and norepinephrine added solutions than 4 mM 4-aminopyridine only, but were not suppressed in 10 mM tetraethylammonium and norepinephrine added solutions compared to 10 mM tetraethylammonium only. Conclusions: These results suggest that norepinephrine blocks the delayed rectifier potassium channels in medial vestibular nuclear neurons.

참고문헌 (21)

  1. "Immunohistochemical demonstration of regionally selective projections from locus coeruleus to the vestibular nuclei in rats", 92, pp.351~359 (1993)
  2. "Relationship of noradrenergic locus coeruleus neurones to vestibulospinal reflexes", 80, pp.329~343 (1989)
  3. "Noradrenergic agents in the cerebellar vermis affect adaptation of the vestibulospinal reflex gain", 35, pp.433~444 (1994)
  4. "Characteristicas and response differences to iontophoretically applied norepinephrine,D-amphetamine and acetylcholine on neurons in the medial and lateral vestibular nuclei of the rat", 112, pp.77~90 (1976)
  5. "Effects of norepinephrine on the firing rate of vestibular neurons", 53, pp.149~158 (1993)
  6. "Modulation of rat medial vestibular nucleus neurone activity by vasopressin and norepinephrine in vitro", 298, pp.91~94 (2001)
  7. "Potassium currents and excitability in second-order auditory and vestibular neurons", 53, pp.511~520 (1998)
  8. "Isolation of neurons suitable for patch- clamping from adult mammalian central nervous systems", 16, pp.227~238 (1986)
  9. "Improved patch clamp techniques for high resolution current recording from cells and cell free membrane patches", 391, pp.85~100 (1981)
  10. "Fos-protein expression in noradrenergic locus coeruleus neurons after unialteral labyrinthectomy in the rat", 136, pp.83~102 (1998)
  11. "endogenous levels of turnover", mo(amines repinephrine), pp.391~401
  12. "Effect of hemilabyrinthectomy on monoamine metabolism in the medial vestibular nucleus,locus coeruleus,and other brainstem nuclei of albino and pigmented rats", 6, pp.243~253 (1996)
  13. "Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals", 30, pp.181~197 (1989)
  14. "Distribution of alpha 1 adrenoreceptors in rat brain revealed by in situ hybridization experiments using subtype-specific probes", 14, pp.4252~4268 (1994)
  15. "Distribution of alpha 1A-adrenergic receptor mRNA in the rat brain visualized by in situ hybridization", 386, pp.358~378 (1997)
  16. "Medial vestibular nucleus in the guinea-pig I.Intrinsic membrane properties in brainstem slices", 84, pp.417~425 (1991)
  17. "Medial vestibular nucleus in the guinea-pig:apamin-induced rhythmic burst firing-an in vitro and in vivo study", 95, pp.213~222 (1993)
  18. "Ionic conductances contributing to spike repolarization and after-potential in rat medial vestibular nucleus neurones", 481, pp.61~77 (1994)
  19. "Candidate cellular mechanisms of vestibulo-ocular reflex plasticity", 781, pp.489~498 (1996)
  20. "Medial vestibular nucleus in the guinea-pig II.Ionic basis of the intrinsic membrane properties in brainstem slices", 84, pp.426~433 (1991)
  21. "The differential expression of low threshold sustained potassium current contributes to the distinct firing patterns in embryonic central vestibular neurons", 18, pp.1449~1464 (1998)

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