내측전정핵 뉴론 안정 활성도 증가에 미치는5-Hydroxytryptamine의 작용
Excitatory Effects of 5-Hydroxytryptamine on the Resting Activity of Medial Vestibular Nuclear Neurons in the Rat
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Abstract
Background and Objectives：This study was aimed to investigate the efects of 5-Hydroxytryptamine (5-HT) on the sponta-neous activity of medial vestibular nuclear neurons of the rat. Materials and Method：Sprague-Dawley rats aged 14 to 16 days neuron was obtained by micropunching. The disociated neurons were transferred into a recording chamber mounted on an inverted microscope and spontaneous action potentials were recorded by standard patch-clamp techniques. Results：The response of medial vestibular nuclear neurons to 5-HT applied in the recording chamber was not uniform. The spontaneous action potentials were increased in 10 cells, decreased in 3 cells and not altered in 2 of 15 cells. The spike width of the neurons was not afterhyperpolarization was decreased by 5-HT. Conclusion：These results suggest 5-HT increases spontaneous firing of the medial vestibular nuclear neurons by altering the afterhyperpolarization.
참고문헌 (20)
- "The vestibular system. In: Patton HD, Hille B, Scher AMand steiner RL, editors.", pp.582~ (1989), Philadelphia: Saunders
- "Axonal trajectoriesof inhibitory vestibulocollic neurons activated by the anteriorsemicircular canal nerve and their synaptic effects on neckmotoneurons in the cat", 82, pp.14~24 (1990)
- "Quantitative autoradiographic mapping ofserotonin receptors in the rat brain. I. Serotonin-1 receptors.", 346, pp.173~178 (1985)
- "Distribution of serotonin-immunoreactivity in thecentral nervous system of the rat-cell bodies and terminals", 6, pp.557~618 (1981)
- "Medialvestibular nucleus in the guinea-pig I. Intrinsic membrane propertiesin brainstem slices.", 84, pp.417~425 (1991)
- "The differential expressionof low threshold sustained potassium current contributes to thedistinct firing patterns in embryonic central vestibular neurons", 18, pp.1449~1464 (1998)
- "Isolation of neurons suitable for patch-clampingfrom adult mammalian central nervous system", 16, pp.227~238 (1986)
- "Improvedpatch clamp techniques for high resolution current recording fromcells and cell free membrane patches", 391, pp.85~100 (1981)
- "Neurochemical mechanisms of recoveryfrom peripheral vestibular lesions(Vestibular compensation).", 16, pp.117~133 (1991)
- "Ionic basis for electroresponsiveness and oscillatoryproperties of guinea-pig thalamic neurones in vitro", 349, pp.227~247 (1984)
- "Cellular mechanismsunderlying spontaneous firing in rat suprachiasmatic nucleus:Involvementof a slowly inactivating component of sodium current", 78, pp.1811~1825 (1997)
- "Membraneproperties of rat locus coeruleus neurones", 13, pp.137~156 (1984)
- "Morphology and electrophysilogical propertiesof immunocytochemically identified rat dopamine neurons recordedin vitro", 9, pp.3463~3481 (1989)
- "Spontaneous inhibitory postsynaptic potentialsin hippocampus:Mechanism for tonic inhibition", 200, pp.195~200 (1980)
- "Spontaneous GABAA receptor-mediated inhibitorycurrents in adult rat somatosensory cortex", 75, pp.1573~1588 (1996)
- "Potassium currents andexcitability in second-order auditory and vestibular neurons", 53, pp.511~520 (1998)
- "K+ channels in the central nervous system. In: Cook NS,editors. Potassium channels, structure, classification, function andtherapeutic potential.", pp.348~381 (1990), New York: John Wiley & Sons
- "Excitation andinhibition of rat medial vestibular nucleus neurones by 5-hydroxytryptamine", 93, pp.293~298 (1993)
- "Effects of 5-hydroxytryptamine on potassium currents of the medial vestibularnuclear neuron in the rat", 46, pp.915~921 (2003)
- "Excitatoryeffects of 5-hydroxytryptamine on the medial vestibular nuclearneuron via the 5-HT2 receptor", 14, pp.2001~2004 (2003)